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¿Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions…mehr

Produktbeschreibung
¿Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GB, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 15.06.2015
  • Englisch
  • ISBN-13: 9781493925315
  • Artikelnr.: 43795313
Autorenporträt
Juan-Francisco Martín, PhD
University of León, Department of Molecular Biology, Area of Microbiology, León, Spain

Carlos García-Estrada, DVM, PhD
Institute of Biotechnology of León (INBIOTEC), Parque Científico de León, León, Spain

Susanne Zeilinger, PhD
Vienna University of Technology, Institute of Chemical Engineering, Vienna, Austria
Inhaltsangabe
Preface

Contributors

Chapter 1. Fungal Secondary Metabolites in the "OMICS" Era

Susanne Zeilinger, Carlos García-Estrada, and Juan-Francisco Martín

Chapter 2. Key Players in the Regulation of Fungal Secondary Metabolism

Benjamin P. Knox and Nancy P. Keller

Chapter 3. Epigenetics of Fungal Secondary Metabolism Related Genes

Ming-Yueh Wu and Jae-Hyuk Yu

Chapter 4. Genome Mining for Fungal Secondary Metabolic Gene Clusters

Grayson T. Wawrzyn, Mark A. Held, Sarah E. Bloch, and Claudia Schmidt-Dannert

Chapter 5. Metagenomics and Metatranscriptomics for the Exploration of Natural Products from Soil Fungi

Irshad Ul Haq and Jan Dirk van Elsas

Chapter 6. Metabolomics and Secondary Metabolite Profiling of Filamentous Fungi

Bernhard Kluger, Sylvia Lehner, and Rainer Schuhmacher

Chapter 7. Fungal Chemotaxonomy

Jens C. Frisvad

Chapter 8. Endophytic Fungi as a Source of Novel Metabolites

Fernanda O. Chagas, Andrés Mauricio Caraballo-Rodriguez, and Mônica T. Pupo

Chapter 9. Fungal Secondary Metabolism in the Light of Animal-Fungus Interactions: From Mechanism to Ecological Function

Marko Rohlfs

Chapter 10. Fusarium Mycotoxins and Their Role in Plant-Pathogen Interactions

Gerhard Adam, Gerlinde Wiesenberger, and Ulrich Güldener

Chapter 11. Biosynthesis and Molecular Genetics of Peptaibiotics - Fungal Peptides Containing Alpha, Alpha - Dialkyl Amino Acids

Xiao-Yan Song, Bin-Bin Xie, Xiu-Lan Chen, Yu-Zhong Zhang