The Genetics of Neurodevelopmental Disorders (eBook, ePUB)

Redaktion: Mitchell, Kevin J.

• Format: ePub

Produktbeschreibung

Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 368
• Erscheinungstermin: 4. August 2015
• Englisch
• ISBN-13: 9781118524978
• Artikelnr.: 43590974

Autorenporträt

Kevin J. Mitchell is an Associate Professor at the Smurfit Institute of Genetics and Institute of Neuroscience at Trinity College Dublin

Inhaltsangabe

Foreword Kevin J. Mitchell 1. The Genetic Architecture of
Neurodevelopmental Disorders Kevin J. Mitchell 2. Overlapping Etiology of
Neurodevelopmental Disorders Eric Kelleher and Aiden Corvin 3. The
Mutational Spectrum of Neurodevelopmental Disorders Nancy D. Merner,
Patrick A. Dion and Guy A. Rouleau 4. The Role of Genetic Interactions in
Neurodevelopmental Disorders Jason H. Moore and Kevin J. Mitchell 5.
Developmental Instability, Mutation Load, and Neurodevelopmental Disorders
Ronald A. Yeo and Steven W. Gangestad 6. Environmental Factors and
Gene-Environment Interactions John McGrath 7. The Genetics of Brain
Malformation M. Chiara Manzini and Christopher A. Walsh 8. Disorders of
Axon Guidance Heike Blockus and Alain Chédotal 9. Synaptic Disorders
Catalina Betancur and Kevin J. Mitchell 10. Human Stem Cell Models of
Neurodevelopmental Disorders Peter Kirwan and Frederick J. Livesey 11.
Animal Models for Neurodevelopmental Disorders Hala Harony-Nicolas and
Joseph D. Buxbaum 12. Cascading Genetic and Environmental Effects on
Development: Implications for Intervention Esha Massand and Annette
Karmiloff-Smith 13. Human Genetics and Clinical Aspects of
Neurodevelopmental Disorders Gholson J. Lyon and Jason O'Rawe 14. Progress
Toward Therapies and Interventions for Neurodevelopmental Disorders
Ayokunmi Ajentunmobi and Daniela Tropea