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A new, fully updated edition of the world s most famous book on liver diseases with updating of all areas and inclusion of new specific topics, by internationally renowned specialists This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world s leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th…mehr

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Produktbeschreibung
A new, fully updated edition of the world s most famous book on liver diseases with updating of all areas and inclusion of new specific topics, by internationally renowned specialists This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world s leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category. Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fibrogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fibrosis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website. Internationally recognized and loved, world-renowned hepatology book, first published in 1955 Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock s clarity and legacy of presentation Full colour throughout with 700 illustrative figures Wide faculty of international contributors Sherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 832
  • Erscheinungstermin: 08.06.2018
  • Englisch
  • ISBN-13: 9781119237648
  • Artikelnr.: 53057462
Autorenporträt
James S. Dooley, The Royal Free Hospital, London, UK.

Anna S. Lok, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Guadalupe Garcia-Tsao, Yale University School of Medicine, VA-CT Healthcare System, CT, USA.

Massimo Pinzani, UCL Institute for Liver and Digestive Health, London, UK.
Inhaltsangabe
List of Contributors xi Preface to the Thirteenth Edition xv Preface to the First Edition xvi 1. Anatomy and Function 1 Jay H. Lefkowitch Development of the liver and bile ducts 1 Anatomy of the liver 1 Functional liver anatomy: sectors and segments 3 Anatomical abnormalities of the liver 3 Anatomy of the biliary tract 4 Surface marking 5 Methods of examination 6 Microanatomy of the liver 7 Hepatic ultrastructure (electron microscopy) and organelle functions 9 Functional heterogeneity of the liver 13 Dynamics of the hepatic microenvironment in physiology and disease 14 Hepatocyte death and regeneration 15 References 16 2 Liver Function in Health and Disease: Clinical Application of Liver Tests 20 George Mells and Graeme Alexander Bilirubin metabolism 21 Bile acids 23 Lipid and lipoprotein metabolism 26 Amino acid metabolism 28 Plasma proteins 29 Carbohydrate metabolism 31 Markers of hepatocellular injury: the serum transaminases 32 Markers of cholestasis: alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) 33 Haematology in liver disease 34 Effects of ageing on the liver 35 References 36 3 Biopsy of the Liver 39 David Patch and Tu Vinh Luong Selection and preparation of the patient 39 Techniques 40 Risks and complications 43 Sampling variability 45 Naked-eye appearances 46 Preparation of the specimen 46 Interpretation: a stepwise diagnostic approach 46 Indications 48 Special methods 49 References 50 4 Coagulation in Cirrhosis 53 Nicolas M. Intagliata and Stephen H. Caldwell Introduction 53 Normal coagulation pathways: a hepatologist's perspective 54 The coagulation system in cirrhosis 56 Bleeding and thrombosis in cirrhosis 57 Clinical laboratory tests of the coagulation system in cirrhosis 58 Conclusion 60 References 60 5 Acute Liver Failure 62 Shannan R. Tujios and William M. Lee Definition 62 Epidemiology and aetiologies 63 Clinical features 66 Initial investigations 67 Complications and management of acute liver failure 68 Specific therapies 73 Prognosis 75 Liver transplantation 76 Conclusion 78 References 78 6 Hepatic Fibrogenesis 82 Meena B. Bansal and Scott L. Friedman Introduction 82 Natural history of hepatic fibrosis 82 Cellular and molecular features of hepatic fibrosis 83 Clinical aspects of hepatic fibrosis 89 Emerging antifibrotic targets and strategies 89 References 90 7 Non-invasive Assessment of Fibrosis and Cirrhosis 93 Avik Majumdar and Massimo Pinzani Introduction 93 The use of invasive and non-invasive tests 93 Non-invasive tests: specifics 95 Conclusions 102 References 103 8 Hepatic Cirrhosis 107 P. Aiden McCormick and Rajiv Jalan Definition 107 Causes of cirrhosis 107 Anatomical diagnosis 108 Reversible cirrhosis 110 Clinical cirrhosis: compensated versus decompensated 110 Prognosis (Child-Pugh score, MELD, UKELD) 111 Clinical and pathological associations 112 Management 119 Acute-on-chronic liver failure 120 References 123 9 Ascites 127 Guadalupe Garcia-Tsao Mechanisms of ascites formation 127 Clinical features 130 Differential diagnosis 132 Spontaneous bacterial peritonitis 132 Treatment of cirrhotic ascites 134 Hyponatraemia 138 Refractory ascites 139 Hepatorenal syndrome 141 Prognosis 144 References 145 10 Hepatic Encephalopathy in Patients with Cirrhosis 151 Marsha Y. Morgan Clinical Features 151 Classification 153 Prevalence and consequences 154 Diagnosis 154 Diagnostic comorbidities, confounders, and alternatives 160 Pathogenesis 161 Management 167 Prevention 174 References 174 11 Portal Hypertension in Cirrhosis 180 Jaime Bosch and Annalisa Berzigotti Introduction 180 Pathophysiology and rational basis of therapy 185 Evaluation and diagnosis 188 Natural histo