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This book provides wide-ranging coverage of parametric modeling in linear and nonlinear mixed effects models. It presents a rigorous approach for describing, implementing, and using mixed effects models. With these models, readers can perform parameter estimation and modeling across a whole population of individuals at the same time. The book takes readers through the whole modeling process, from defining/creating a parametric model to performing tasks on the model using various mathematical methods. Numerous examples illustrate how to implement the models using the Monolix software.
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"Although there are many excellent books available on mixed linear models and generalized linear mixed models, few provide broad coverage of nonlinear models. The strength of this text is the extensive coverage of the modeling of nonlinear trajectories in a wide variety of forms." (Journal of the American Statistical Association)
"... the text contains much of interest to the applied statistician who may be working as a consultant. ... I found the text useful to explain the difference between individual and population models so I have no hesitation in recommending this book for applied statisticians who may need a few well-developed examples from which to explain, and explore, statistical concepts and hierarchical modeling with non-statistical clients. In addition to model formulation and parameter estimation, the author addresses topics in model selection and diagnostic tools, too. ... a valuable text that is well-worth reading ..."
-International Statistical Review, 2015
"... it is very precise ... I was pleasantly surprised at how readable it was ... a very good addition to the books of Davidian and Giltinan and Bonate. ... an essential companion to the Monolix software ... I would highly recommend it to all practitioners of the population approach for the systematic and thorough way it presents the subject."
-CPT: Pharmacometrics & Systems Pharmacology, 2015
"... the first combination of a 'how-to' framework for statisticians and mathematicians with a thorough description of the statistical and mathematical models for users with a clinical background. ... an excellent book on how to model biopharmaceutical data with a very good structure and solid lecture materials."
-Julie Bertrand, Journal of Biopharmaceutical Statistics
"... the text contains much of interest to the applied statistician who may be working as a consultant. ... I found the text useful to explain the difference between individual and population models so I have no hesitation in recommending this book for applied statisticians who may need a few well-developed examples from which to explain, and explore, statistical concepts and hierarchical modeling with non-statistical clients. In addition to model formulation and parameter estimation, the author addresses topics in model selection and diagnostic tools, too. ... a valuable text that is well-worth reading ..."
-International Statistical Review, 2015
"... it is very precise ... I was pleasantly surprised at how readable it was ... a very good addition to the books of Davidian and Giltinan and Bonate. ... an essential companion to the Monolix software ... I would highly recommend it to all practitioners of the population approach for the systematic and thorough way it presents the subject."
-CPT: Pharmacometrics & Systems Pharmacology, 2015
"... the first combination of a 'how-to' framework for statisticians and mathematicians with a thorough description of the statistical and mathematical models for users with a clinical background. ... an excellent book on how to model biopharmaceutical data with a very good structure and solid lecture materials."
-Julie Bertrand, Journal of Biopharmaceutical Statistics