Immune Dysfunction and Immunotherapy in Heart Disease (eBook, PDF)

Redaktion: Watson, Ronald Ross; Larson, Douglas

• Format: PDF

Produktbeschreibung

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction. The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area. The four parts of the book address: * * Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes * Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs * Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs * Immune Dysfunction Leading to Heart Disease: Induction by Pathogens Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 328
• Erscheinungstermin: 8. Mai 2008
• Englisch
• ISBN-13: 9780470766514
• Artikelnr.: 37299053

Autorenporträt

Dr. Larson and Dr. Watson have worked together researching the role of immune and cytokine dysfunction in heart disease for 8 years. They have been and currently are funded to do such research by grants from the U.S. National Institute of Heart, Lung and Blood, the American Heart Foundation, companies and private foundations. Dr. Watson has edited 62 scientific books, including several dealing with heart disease and conditions such as aging and AIDS that promote immune dysfunction as well as heart disease. Dr. Larson directs the Center's organ perfusion program as well as its Master degree in pharmacology and toxicology for perfusion students. ____________________________________________________________________ Ronald Ross Watson Ph.D. Professor Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245155, 1501 N. Campbell Avenue, Tucson, AZ 85749. [phone], Fax [phone] rwatson(at)u.arizona.edu ____________________________________________________________________ Douglas F. Larson Ph.D. Professor Surgery and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell Avenue, Tucson, AZ 85749. [phone] dflarson(at)email.arizona.edu

Inhaltsangabe

PART 1: Immune Dysfunction Leading to Heart Disease: Induction by
Physiological Changes. 01 Immunosuppression by Ultraviolet Light-B
Radiation: a Mediator of Cardiac Remodeling. 02 Immune Mechanisms In
Pediatric Cardiovascular Disease. 03 Heart failure - role of autoimmunity.
04 Immune basis of Hypertension in Humans. 05 Immune Dysregulation:
Potential Mediator of Metabolic Syndrome-Induced Cardiac Remodeling. 06
T-Helper 2 Cell Cytokines In Remodelling Of Aortic Wall. 07 Effects of
TNF-alpha on Cardiac Function. 08 Immunosuppression in Promotion of Cardiac
Allograft Vasculopathy. 09 Immunotherapy for left ventricular dysfunction
after heart transplantation. PART 2: Immune Dysfunction Promoting CVD:
Induction by Transplantation Drugs. 10 Immunmodulating therapy in chronic
heart failure. 11 Statins in Atherosclerosis: Role of Immune Regulation. 12
ACE Inhibitors as Immunmodulators: Treatment of Cardiovascular Disease. 13
Treatment of Heart Failure by Anticytokine Therapies. PART 3: Immune
Dysfunction Leading to Heart Dysfunction: Induction or prevention by
Cardiotherapeutic Drugs. 14 Pathogenesis Of Cardiovascular Complications In
The Acquired Immunodeficiency Syndrome. 15 Cytokines and T cell-Mediated
Responses in Autoimmune Myocarditis. 16 Drugs of abuse: Accentuation of
immunomodulation of viral myocarditis. PART 4: Immune Dysfunction Leading
to Heart Disease: Induction by Pathogens. 17 Osteopontin: The link between
the Immune System and cardiac remodeling. 18 Inflammatory immune activation
in heart failure patients; Therapeutic implications. 19 Role of Innate
Immune Dysregulation in Diabetic Heart Failure. 20 Tolerance in Heart
Transplantation: Current and Future Role. 21 Neutralization of Th2
cytokines in therapy of cardiovascular pathology. 22 Anti-inflammatory
immune therapy in heart disease. 23 Cholesterol Synthesis, Interleukin 6
inflammation and Atherosclerosis - Role of statins, bisphosphonates and
plant polyphenols in Atherosclerosis and other diseases of Aging. 24
Autoimmune myocarditis. Treatment with anti-T-cell antibodies. 25
Immunosuppressive Therapy To Counter Cardiac Allograft Vasculopathy. 26
Immunosuppression by Ultraviolet Light-B Radiation: a Mediator of Cardiac
Remodeling. 27 Role of oral pathogens in the pathogenesis of coronary heart
disease. 28 Myocardial regenerative potential by stem cell transplant. 29
Bioflavanoids and Dietary Anti-Inflammatory Actions: Role in Cardiovascular
Diseases