Acetylcholine in the Cerebral Cortex (eBook, PDF)

Redaktion: Descarries, L.; Steriade, M.; Krnjevic, K.

• Format: PDF

Produktbeschreibung

Comprehensive exposé, by leading neuroscientists, of current knowledge on the neurotransmitter acetylcholine in the cerebral cortex. All aspects of the subject are covered, from its most elementary, at the molecular and cellular levels, to its systemic and holistic implications, including its role in cognition and involvement in human diseases and therapeutics.

The twenty-two chapters are grouped under four main headings : I. Functional Morphology of the Acetylcholine Innervation in Cerebral Cortex (Including Hippocampus); II. Modes of Action of Acetylcholine in the Cerebral Cortex; III. Cortical Properties and Functions Modulated by Acetylcholine, and IV. Clinical, Pathological and Therapeutic Implications. This broad perspective updates the reader on recent advances and future trends in the study of a major neuromodulatory system in brain.

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 344
• Erscheinungstermin: 31. Oktober 2003
• Englisch
• ISBN-13: 9780080545844
• Artikelnr.: 52948013

Inhaltsangabe

List of contributors. Preface. Acknowledgements. I. The Acetylcholine
Innervation of Cerebral Cortex. 1. Phylogenetic and ontogenetic aspects of
the basal forebrain cholinergic neurons and their innervation of the
cerebral cortex
(K. Semba). 2. Structural determinants of the roles of acetylcholine in
cerebral cortex (L. Descarries, N. Mechawar et al.). 3. Muscarinic
acetylcholine receptor subtypes in cerebral cortex and hippocampus (L.A.
Volpicelli, A.I. Levey). 4. The cholinergic innervation of the human
cerebral cortex
(M.-M. Mesulam). II. Modes of Action of Acetylcholine in the Cerebral
Cortex. 5. Synaptic mechanisms modulated by acetylcholine in cerebral
cortex (K. Krnjević). 6. Functional and molecular characterization
of neuronal nicotinic ACh receptors in rat hippocampal interneurons (J.L.
Yakel, Z. Shao). 7. The nicotinic acetylcholine receptor subtypes and their
function in the hippocampus and cerebral cortex
(M. Alkondon, E.X. Albuquerque). 8. Studies of muscarinic neurotransmission
with antimuscarinic toxins (L.T. Potter, D.D. Flynn et al.). III. Cortical
Properties and Functions Modulated by Acetylcholine. 9. Hyperactivation of
developing cortical circuits by acetylcholine and the ontogeny of abnormal
cognition and emotion: findings and hypothesis (A. Peinado, D.P. Calderon).
10. Synaptic mechanisms and cholinergic regulation in auditory cortex (R.
Metherate, C. Hsieh). 11. Activity, modulation and role of basal forebrain
cholinergic neurons innervating the cerebral cortex (B.E. Jones). 12.
Cholinergic modulation of the cortical microvascular bed
(E. Hamel). 13. Acetylcholine systems and rhythmic activities during the
waking-sleep cycle (M. Steriade). 14. Cholinergic mechanisms mediating
anaesthetic induced altered states of consciousness (S.B. Backman, P.
Fiset, G. Plourde). 15. High acetylcholine sets circuit dynamics for
attention and encoding; Low acetylcholine sets dynamics for consolidation
(M.E. Hasselmo, J. McGaughy). IV. Clinical, Pathological and Therapeutic
Implications. 16. Knock-out and knock-in mice to investigate the role of
nicotinic receptors in the central nervous system (N. Champtiaux, J.-P.
Changeux). 17. Nicotinic modulation of thalamocortical neurotransmission
(P.B.S. Clarke). 18. Amyloid &bgr; peptides and central cholinergic
neurons: functional interrelationship and relevance to Alzheimer's disease
pathology (S. Kar, R. Quirion). 19. Nicotinic receptor mutations in human
epilepsy (O.K. Steinlein). 20. Neurochemistry of consciousness: cholinergic
pathologies in the human brain
(E.K. Perry, R.H. Perry). 21. Functional studies of cholinergic activity in
normal and Alzheimer disease states by imaging technique (A. Nordberg). 22.
Paying attention to acetylcholine: the key to wisdom and quality of life?
(P.J. Whitehouse). Subject Index.