Jonathan M. W. Slack (UK University of Bath), Leslie Dale (UK University College London)

Essential Developmental Biology

• Broschiertes Buch

Produktbeschreibung

Essential Developmental Biology ist eine umfassende und reich illustrierte Einführung in sämtliche Aspekte der Entwicklungsbiologie. Die 3. Auflage dieses beliebten und zugänglichen Lehrbuchs wurde erweitert und aktualisiert.

Die begleitende Website bietet darüber hinaus Lehr- und Lernmaterialien für Studenten und Dozenten, animierte Entwicklungsprozesse, eine Fotogalerie ausgewählter Modellorganismen und sämtliche Abbildungen usw. der Printversion zum Herunterladen.

Dieses evidenzbasierte Lehrbuch liefert durchgängig Belege für zentrale Schlussfolgerungen und ist ein Muss sowohl für Einführungs- als auch Aufbaukurse der Entwicklungsbiologie.

Produktdetails

• Verlag: Wiley / Wiley & Sons
• Artikelnr. des Verlages: 1W119512850
• 4. Aufl.
• Seitenzahl: 544
• Erscheinungstermin: 16. Dezember 2021
• Englisch
• Abmessung: 275mm x 215mm x 28mm
• Gewicht: 1454g
• ISBN-13: 9781119512851
• ISBN-10: 1119512859
• Artikelnr.: 60123832

Autorenporträt

Professor Jonathan M.W. Slack is an emeritus professor of the University of Bath, UK, where he was Head of the Department of Biology and Biochemistry; and the University of Minnesota, USA, where he was director of the Stem Cell Institute. He is a member of the European Molecular Biology Organization and a Fellow of the Academy of Medical Sciences. He has published numerous research papers on developmental biology as well as five other books, including The Science of Stem Cells (Wiley-Blackwell 2018). Professor Leslie Dale is Professor of Developmental Biology at University College London, UK, where he was Head of Teaching for the Department of Cell and Developmental Biology. He teaches developmental biology to both undergarduate and medical students. For his PhD he studied regeneration in Drosophila imaginal discs and subsequently the development of Xenopus embryos.

Inhaltsangabe

Preface, ix

About the companion website, xi

Section 1: Groundwork, 1

1 The excitement of developmental biology, 3

Where the subject came from, 3

Impact of developmental biology, 4

Future impact, 5

2 How development works, 7

Ultrashort summary, 7

Gametogenesis, 10

Early development, 13

Growth and death, 19

3 Approaches to development: developmental genetics, 25

Developmental mutants, 25

Sex chromosomes, 27

Maternal and zygotic, 27

Genetic pathways, 28

Genetic mosaics, 30

Screening for mutants, 31

Cloning of genes, 32

Gain-and loss-of-function experiments, 32

Transgenesis, 32

Other gain-of- function techniques, 34

Targeted mutagenesis, 34

Other loss-of- function systems, 35

Gene duplication, 36

Limitations of developmental genetics, 37

4 Approaches to development: experimental embryology and its molecular basis, 39

Normal development, 39

Developmental commitment, 42

Criteria for proof, 48

Transcription factors, 48

Transcription factor families, 50

Other controls of gene activity, 51

Signaling systems, 51

Genetic regulatory networks, 57

5 Approaches to development: cell and molecular biology techniques, 61

Microscopy, 61

Optical techniques, 61

Confocal, multi-photon, and light sheet microscopes, 63

Image capture, 63

Anatomical and histological methods, 64

Microinjection, 66

Study of gene expression by molecular biology methods, 67

Study of gene expression by in situ methods, 72

Reporter genes, 75

Cell-labeling methods, 76

6 Cells into tissues, 81

Cells in embryos, 81

Cytoskeleton, 82

Small GTP-binding proteins, 84

Extracellular matrix, 84

Cell movement, 85

Epithelial organization, 86

Morphogenetic processes, 88

Section 2: Major model organisms, 97

7 Major model organisms, 99

The big six, 99

Access and micromanipulation, 101

Genetics and genomes, 101

Relevance and tempo, 102

Other organisms, 102

8 Xenopus, 107

Oogenesis, maturation, and fertilization, 108

Normal development, 109

Fate maps, 114

Experimental methods, 115

Processes of regional specification, 119

9 The zebrafish, 135

Normal development, 135

Fate map, 140

Genetics, 141

Reverse genetic methods, 144

Embryological techniques, 145

Regional specification, 145

Other roles of the zebrafish, 150

10 The chick, 153

Normal development, 154

Fate map, 158

Regional specification of the early embryo, 159

Description of organogenesis in the chick, 164

11 The mouse, 173

Mammalian fertilization, 173

Normal development of the mouse, 177

Fate map, 184

Regional specification in the mouse embryo, 185

Transgenic mice, 190

Embryonic stem cells, 192

Knockouts and knock-ins, 192

Nuclear transplantation and imprinting, 196

X-inactivation, 196

Teratocarcinoma, 198

12 Human early development, 203

Human reproduction, 203

Preimplantation development, 205

Human embryonic stem cells, 207