The CD38 molecule - Mokrane, Ahlem
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CD38 is a transmembrane glycoprotein type II, which is expressed on normal hematopoietic cells and in non-hematopoietic tissues. Notably, CD38 is highly expressed in multiple myeloma, chronic lymphocytic leukemia, and other diseases. CD38 plays several roles, including ectoenzyme, receptor, adhesion molecule, and is involved in signal transduction. The cytotoxic mechanisms of daratumumab, which is considered a new high affinity human therapeutic mAb against a single CD38 epitope. CD38 represents a promising target for mAb-based immunotherapy, which has already and will continue to transform…mehr

Produktbeschreibung
CD38 is a transmembrane glycoprotein type II, which is expressed on normal hematopoietic cells and in non-hematopoietic tissues. Notably, CD38 is highly expressed in multiple myeloma, chronic lymphocytic leukemia, and other diseases. CD38 plays several roles, including ectoenzyme, receptor, adhesion molecule, and is involved in signal transduction. The cytotoxic mechanisms of daratumumab, which is considered a new high affinity human therapeutic mAb against a single CD38 epitope. CD38 represents a promising target for mAb-based immunotherapy, which has already and will continue to transform the treatment landscape into diseases, including multiple myeloma.
  • Produktdetails
  • Verlag: Lap Lambert Academic Publishing
  • Seitenzahl: 84
  • Englisch
  • Abmessung: 220mm x 150mm
  • ISBN-13: 9786138339779
  • ISBN-10: 6138339770
  • Artikelnr.: 51643412
Autorenporträt
Mokrane Ahlem PhD Candidate of Biological Science. Department of Molecular Biology and Biomedicine, UNN. N.I. Lobachevsky, Russia