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Chronic conditions and diseases are the leading cause of mortality and morbidity in Europe, accounting for 86% of total premature deaths, and the burden is likely to grow. The epidemiologic and economic analysis in this book suggests that policy-makers should make chronic disease a priority and focuses on the strategies and interventions to use: prevention and early detection; new provider qualifications and settings; disease management programes; and integrated care models, though evidence on their effectiveness and cost-effectiveness is still limited.Institutional and organizational challenges are also explored and key policy recommendations are made in order to tackle them successfully.