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PRF consists of an autologous leukocyte-platelet-rich fibrin matrix, composed of a tetra molecular structure, with cytokines, platelets, cytokines, and stem cells within it, which acts as a biodegradable scaffold that favors the development of microvascularization and is able to guide epithelial cell migration to its surface.In surgical procedures, PRF could serve as a resorbable membrane for guided bone regeneration (GBR), preventing the migration of non-desirable cells into bone defect and providing a space that allows the immigration of osteogenic and angiogenic cells and permits the underlying blood clot to mineralize.This book is based on the Thesis performed to compare the clinical and radiographic effect of Platelet rich fibrin as a membrane when used along with Bioactive glass versus only Bioactive glass in the intrabony defects of chronic periodontitis patients.