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Cancer is a deadly disease that has touched the lives of many people in the world today.The present work aimed to evaluate the role of -3 FAs supplementation either alone or combined with fractionated Gamma-radiation exposure against Ehrlich solid tumor-induced inflammation, oxidative stress, biochemical alterations and histopathological changes in the liver, brain and tumor tissues of Albino mice. -3 FAs were orally administered via gavages to mice for a period of 30 consecutive days at a dose of 300 mg/kg body weight.