New Piperazine Derivatives: Biologic and Spectroscopic Study - Özbek, Neslihan; Karakurt, Tuncay; Balaban Gündüzalp, Ayla
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A new piperazine derivatives: 2,2'-(piperazine-1,4-diyl)bis(N'-((Z)-2,4-dihydroxybenzylidene)acetohydrazide), 2.2'-(piperazine-1,4-diyl)bis (N'-((Z)-2-hydroxy-4-methoxybenzylidene)acetohydrazide) and 2.2'-(piperazine-1,4-diyl) bis N'-((Z)-1-(2-hydroxynaphthalen-1-yl) ethylidene) aceto hydrazide) were synthesized. The characterization of all compounds was characterized by NMR, FT-IR, Mass spectral data and elemental analysis. 1H and 13C shielding tensors of all compounds were calculated with GIAO/DFT/B3LYP/6-31 G(d) methods in DMSO. Molecular electrostatic potential surface and frontier orbital…mehr

Produktbeschreibung
A new piperazine derivatives: 2,2'-(piperazine-1,4-diyl)bis(N'-((Z)-2,4-dihydroxybenzylidene)acetohydrazide), 2.2'-(piperazine-1,4-diyl)bis (N'-((Z)-2-hydroxy-4-methoxybenzylidene)acetohydrazide) and 2.2'-(piperazine-1,4-diyl) bis N'-((Z)-1-(2-hydroxynaphthalen-1-yl) ethylidene) aceto hydrazide) were synthesized. The characterization of all compounds was characterized by NMR, FT-IR, Mass spectral data and elemental analysis. 1H and 13C shielding tensors of all compounds were calculated with GIAO/DFT/B3LYP/6-31 G(d) methods in DMSO. Molecular electrostatic potential surface and frontier orbital analysis were also carried out. HOMO-LUMO energy gap was calculated which allowed the calculation of relative reactivity descriptors like chemical hardness, chemical inertness, chemical potential, nucleophilicity and electrophilicity index of all compounds. Molecular docking studies of compounds were performed for Lanosterol-14a-demethylase (CYP51) enzyme (PDB ID: 3JUS). The microbiological effect of all compounds were tested against five human pathogenic bacteria and three fungal by using microdilution and disc diffusion methods.
  • Produktdetails
  • Verlag: LAP LAMBERT Academic Publishing
  • Seitenzahl: 96
  • Erscheinungstermin: 24. Oktober 2019
  • Englisch
  • Abmessung: 220mm x 150mm x 6mm
  • Gewicht: 161g
  • ISBN-13: 9786200457592
  • ISBN-10: 620045759X
  • Artikelnr.: 58285633
Autorenporträt
Neslihan  Özbek was born in Erzurum in 1972. She finished high school in Erzurum. She graduated from Gazi University Faculty of Chemistry in 1994. She received his PhD at Gazi University in 2008 and became a professor in 2019. She has been working at Ahi Evran University since 1999. She has one kid.