The third International Meeting on "Low Molecular Weight Sulfur Containing Natural Products,"sponsored by the International Union of Pure and Applied Chemistry, was held in the historical building of the Accademia Nazionale dei Lincei, Rome, Italy, June 18-21, 1979. The symposium was held in order to exchange knowledge in the intriguing and complex field of sulfur biochemistry. This theme brought together scientists from many speciali zed areas from organic and physical chemistry to biology and medicine. The interdisciplinary nature of the meeting gave to the participants the opportunity to…mehr
The third International Meeting on "Low Molecular Weight Sulfur Containing Natural Products,"sponsored by the International Union of Pure and Applied Chemistry, was held in the historical building of the Accademia Nazionale dei Lincei, Rome, Italy, June 18-21, 1979. The symposium was held in order to exchange knowledge in the intriguing and complex field of sulfur biochemistry. This theme brought together scientists from many speciali zed areas from organic and physical chemistry to biology and medicine. The interdisciplinary nature of the meeting gave to the participants the opportunity to discuss pro blems of common interest approached from different scienti fic standpoints. This volume contains 47 contributions presented at the meeting which mainly deal with new structural and metabolic aspects of sulfur biochemistry. An important aspect of such a scientific meeting is the rapid publication of the proceedings. Through the cooperation of the authors in providing "camera ready" copies of their manuscripts, the good efforts of the Orga nizing Committee, and the Plenum Press Publishing Co., it has been possible to publish this book within a few months of the meeting.
Stereochemical Aspects of Transmethylations of Potential Biological Interest.- Methylase Mechanisms: Steric Constraints and Modes of Catalysis.- Adenosylmethionine as a Precursor for Nucleic Acids Modification.- Involvement of S-Adenosylmethionine in Brain Phospholipid Metabolism.- Effect of S-Adenosyl-L-Methionine and S-Adenosyl-L-Homocysteine Derivatives on Protein Methylation.- The Role of S-Adenosylhomocysteine and S-Adenosylhomocysteine Hydrolase in the Control of Biological Methylations.- Homocysteine Biosynthesis in Plants.- Inhibition of the Synthesis of Glutathione, Glutamine and Glutamate by Certain Methionine Derivatives.- Methionine Metabolism in Developing Neural Tissue.- Antagonists of Folic Acid and Vitamin B6 in Regulation of S-Adenosylmethionine and S-Adenosylhomocysteine Content in Normal and Malignant Tissues.- Recent Studies on the Metabolism of 5'-Methylthioadenosine.- Two Different Modes of Synthesis and Transformation of Cysteine (and Related Amino Acids) by Pyridoxal-P-Dependent Lyases.- Possible Physiological Functions of Taurine in Mammalian Systems.- Cysteine Dioxygenase of Rat Liver: Some Properties and its Significance on Cysteine Metabolism of Rat..- Cysteamine Pathway of Taurine Biosynthesis.- Metabolism of Hypotaurine in Some Organs of the Rat.- Hypotaurine Oxidation by Mouse Tissues.- Sulfur Amino Acids in the Reproductive Tract of Male Guinea Pigs, Rats,Mice and Several Marine Animals.- Hypotaurine in the Reproductive Tract.- Taurine in Human Nutrition and Development.- The Effect of Total Parenteral Nutrition on Taurine.- Taurine and Isethionate in Squid Nerve.- Taurine Biosynthesis in Ox Retina.- The Regulation and Function of Taurine in the Heart and Other Organs.- Effects of Ischemia on Taurine Levels.- Taurine Effects on Calcium Transport in Nervous Tissue.- Taurine in Retinas of Taurine Deficient Cats and RCS Rats.- Thialysine, Thiaisoleucine and Thiaproline as Inhibitors in Protein Synthesizing Systems.- Lanthionine Decarboxylation by Animal Tissues.- Sulfur Containing Nuphar Alkaloids.- Biologically Active 1,2-Dithiolane Derivatives from Mangrove Plants and Related Compounds..- Biochemical and Clinical Effects of Penicillamine and Other Thiols Used in the Treatment of Rheumatoid Arthritis.- Cyanoepithioalkanes: Some Chemical and Toxicological Studies.- Cysteine and Glutathione in Mammalian Pigmentation.- Sulfur Compounds in Mustelids.- On the Mechanism of C-S Bonds Formation in the Biosynthesis of Biotin.- 'The Biosynthesis of Lipoic Acid in the Rat.- Some Aspects of the Metabolism of Sulfur-Containing Heterocyclic Cofactors: Lipoic Acid, Biotin, and 8a-(S-L-cysteinyl) Riboflavin.- Implication of Essential Fatty Acids in Pyruvate Dehydrogenase Activation.- Stimulation of Fatty Acid Metabolism by Panteth (e) ine.- Effects of a Hypolipidemic Drug (Clofibrate) on the Biosynthesis and Degradation of CoA in Rat Liver.- Clinical Chemistry of Mercaptopyruvate and its Metabolites.- Spectral Properties of Persulfide Sulfur in Rhodanese.- Biochemistry of Thiocystine.- Subcellular Compartmentation and Biological Functions of Mercaptopyruvate Sulphurtransferase and Rhodanese.- Semisynthetic Cephalosporins. III. Synthesis and Structure Activity Relationships of Novel Orally Active 7-[4-Hydroxy- 3-(Substituted Methyl)Phenyl]- ceta-mido-3-Cephem-4-Carboxylic Acids.- Ambiguities in the Enzymology of Sulfur-Containing Compounds.- Contributors.
Stereochemical Aspects of Transmethylations of Potential Biological Interest.- Methylase Mechanisms: Steric Constraints and Modes of Catalysis.- Adenosylmethionine as a Precursor for Nucleic Acids Modification.- Involvement of S-Adenosylmethionine in Brain Phospholipid Metabolism.- Effect of S-Adenosyl-L-Methionine and S-Adenosyl-L-Homocysteine Derivatives on Protein Methylation.- The Role of S-Adenosylhomocysteine and S-Adenosylhomocysteine Hydrolase in the Control of Biological Methylations.- Homocysteine Biosynthesis in Plants.- Inhibition of the Synthesis of Glutathione, Glutamine and Glutamate by Certain Methionine Derivatives.- Methionine Metabolism in Developing Neural Tissue.- Antagonists of Folic Acid and Vitamin B6 in Regulation of S-Adenosylmethionine and S-Adenosylhomocysteine Content in Normal and Malignant Tissues.- Recent Studies on the Metabolism of 5'-Methylthioadenosine.- Two Different Modes of Synthesis and Transformation of Cysteine (and Related Amino Acids) by Pyridoxal-P-Dependent Lyases.- Possible Physiological Functions of Taurine in Mammalian Systems.- Cysteine Dioxygenase of Rat Liver: Some Properties and its Significance on Cysteine Metabolism of Rat..- Cysteamine Pathway of Taurine Biosynthesis.- Metabolism of Hypotaurine in Some Organs of the Rat.- Hypotaurine Oxidation by Mouse Tissues.- Sulfur Amino Acids in the Reproductive Tract of Male Guinea Pigs, Rats,Mice and Several Marine Animals.- Hypotaurine in the Reproductive Tract.- Taurine in Human Nutrition and Development.- The Effect of Total Parenteral Nutrition on Taurine.- Taurine and Isethionate in Squid Nerve.- Taurine Biosynthesis in Ox Retina.- The Regulation and Function of Taurine in the Heart and Other Organs.- Effects of Ischemia on Taurine Levels.- Taurine Effects on Calcium Transport in Nervous Tissue.- Taurine in Retinas of Taurine Deficient Cats and RCS Rats.- Thialysine, Thiaisoleucine and Thiaproline as Inhibitors in Protein Synthesizing Systems.- Lanthionine Decarboxylation by Animal Tissues.- Sulfur Containing Nuphar Alkaloids.- Biologically Active 1,2-Dithiolane Derivatives from Mangrove Plants and Related Compounds..- Biochemical and Clinical Effects of Penicillamine and Other Thiols Used in the Treatment of Rheumatoid Arthritis.- Cyanoepithioalkanes: Some Chemical and Toxicological Studies.- Cysteine and Glutathione in Mammalian Pigmentation.- Sulfur Compounds in Mustelids.- On the Mechanism of C-S Bonds Formation in the Biosynthesis of Biotin.- 'The Biosynthesis of Lipoic Acid in the Rat.- Some Aspects of the Metabolism of Sulfur-Containing Heterocyclic Cofactors: Lipoic Acid, Biotin, and 8a-(S-L-cysteinyl) Riboflavin.- Implication of Essential Fatty Acids in Pyruvate Dehydrogenase Activation.- Stimulation of Fatty Acid Metabolism by Panteth (e) ine.- Effects of a Hypolipidemic Drug (Clofibrate) on the Biosynthesis and Degradation of CoA in Rat Liver.- Clinical Chemistry of Mercaptopyruvate and its Metabolites.- Spectral Properties of Persulfide Sulfur in Rhodanese.- Biochemistry of Thiocystine.- Subcellular Compartmentation and Biological Functions of Mercaptopyruvate Sulphurtransferase and Rhodanese.- Semisynthetic Cephalosporins. III. Synthesis and Structure Activity Relationships of Novel Orally Active 7-[4-Hydroxy- 3-(Substituted Methyl)Phenyl]- ceta-mido-3-Cephem-4-Carboxylic Acids.- Ambiguities in the Enzymology of Sulfur-Containing Compounds.- Contributors.
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