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Garlic and Zataria multiflora boiss (ZMB) are herbal medicines used traditionally in treatment of infections including candidal vaginitis. This work aimed to examine the effect of garlic and ZMB vaginal cream 2% on treatment and recurrence of candidal vaginitis. This randomized, double-blinded clinical trial conducted on 240 married women with candidal vaginitis. The patients used 5gr garlic, ZMB or clotrimazol vaginal cream 2% daily for 7 days. Complaints of the patients, clinical observations and laboratory parameters were studied before treatment, at days 7 and 30 after treatment. The data was analyzed by SPSS /13 21 through chi-square, Fisher, ANOVA with repeated measures, McNemar and Kruskal-Wallis tests. P0.05 was considered significant. Garlic and ZMB vaginal cream 2% can be used as an effective treatment option in cases of drug resistance and also by the people who are interested in treating with herbal medicines.