Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the…mehr
Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.
Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.
AKHLAQ FAROOQUI is an Adjunct Associate Professor of Medical Biochemistry at Ohio State University. He is author of over 180 peer-reviewed research articles, and author/editor of eight books and an expert in fields of glycerophospholipid metabolism, excitotoxicity, bioactive ether lipids, and phospholipases A2 in brain. TAHIRA FAROOQUI is a Research Scientist in the Department of Entomology at Ohio State University. She is the author of 40 peer-reviewed research articles and several monographs and an expert on glycerophospholipid and sphingolipid metabolism, biogenic amines, and neural plasticity.
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Foreword Mark P. Mattson xi Preface Tahira Farooqui and Akhlaq A. Farooqui xiii Acknowledgments Tahira Farooqui and Akhlaq A. Farooqui xv Contributors xvii 1 Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease 1 Suzanne M. de la Monte and Ming Tong 2 Insulin Receptor and the Pathophysiology of Alzheimer Disease 31 Johanna Zemva and Markus Schubert 3 Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease 51 Adnan Erol 4 Insulin-Leptin Signaling in the Brain 75 Vicente Barrios, Emma Burgos-Ramos, and Jes us Argente 5 The Janus Face of Insulin in Brain 85 Ana Duarte, Emanuel Candeias, S onia C. Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I. Pl acido, Maria S. Santos, Catarina R. Oliveira, and Paula I. Moreira 6 Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease 115 Maite Solas and Maria J. Ram ?rez 7 Contribution of Phospholipid, Sphingolipids, and Cholesterol-Derived Lipid Mediators in the Pathogenesis of Metabolic Syndrome and Neurological Disorders 137 Akhlaq A. Farooqui and Tahira Farooqui 8 Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated Neurotoxicity 163 Mun'delanji C. Vestergaard, Masamune Morita, Tsutomu Hamada, and Masahiro Takagi 9 Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals 179 Giulio Maria Pasinetti, Amanda Bilski, Lap Ho, Jun Wang, Mario Ferruzzi, Masahito Yamada, Kenjiro Ono, and Salvatore Mannino 10 Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction 191 Jae-Sung Lim and Hyung-Min Kwon 11 Neurochemical Linkage Among Metabolic Syndrome, Alzheimer Disease, and Depression 197 Undurti N. Das 12 Alterations in the Endocannabinoid System as a Link Between Unbalanced Energy Homeostasis, Neuroinflammation, and Neurological and Neuropsychiatric Disorders 219 Tiziana Bisogno and Vincenzo Di Marzo 13 Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides 235 George Anderson and Michael Maes 14 Binge Eating and Metabolic Syndrome 249 Ignacio J auregui-Lobera 15 Phytochemical Principles in the Traditional Indian System of Medicine Used for the Management of Metabolic Syndrome 261 Syed Ibrahim Rizvi and Neetu Mishra 16 Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome 275 Morihiro Matsuda and Iichiro Shimomura 17 The Relationship Among Obesity, Inflammation, and Insulin Resistance 283 Jean-Philippe Bastard and Bruno F`eve 18 Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome 297 Hardik Gandhi and Ramachandran Balaraman 19 Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue 311 Paolo Calabro, Enrica Golia, Valeria Maddaloni, Giuseppe Limongelli, Brunella Ziello, Fabio Fimiani, Ilaria Jane Romano, Mario Crisci, Maria Giovanna Russo, Edward T.H. Yeh, and Raffaele Calabro 20 Is Diabetes a Risk Factor for Parkinson Disease? 327 Akhlaq A. Farooqui and Tahira Farooqui 21 Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome 335 Lu Cai 22 Contributions of AMP Kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases 363 Mohamed Kodiha, Hicham Mahboubi, and Ursula Stochaj 23 A_ Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes 383 Naoyuki Sato and Ryuichi Morishita 24 In Vivo Evidence of the Convergence of Type 2 Diabetes and Alzheimer Disease 395 Sun Ah Park 25 Metabolic Syndrome and its Impact on Cardiovascular Disease 409 John A. Larry 26 Contribution of Inflammation, Adiponectin, and Obesity in Cardiovascular Diseases 423 Harald Mangge and Gunter Almer 27 Brain and Cardiovascular Diseases: Molecular Aspects 439 Ewa Szczepanska-Sadowska 28 Molecular Aspects of Dietary-Exercise Regimen for the Prevention of Metabolic Syndrome 461 Wataru Aoi 29 Ghrelin, Lipid Metabolism, and Metabolic Syndrome 475 Pablo B. Mart ?nez de Morentin, Sulay Tovar, Rub en Nogueiras, Miguel L opez, and Carlos Di eguez 30 Leptin and Cognitive Function 485 Jenni Harvey 31 Fructose, Sugar Consumption, and Metabolic Diseases 501 Virgile Lecoultre and Luc Tappy 32 Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome 515 Nathalie Castanon and Sophie Lay e 33 Summary and Perspective 529 Tahira Farooqui and Akhlaq A. Farooqui Index 539 Color plate section is located between pages 196 and 197.
Foreword Mark P. Mattson xi Preface Tahira Farooqui and Akhlaq A. Farooqui xiii Acknowledgments Tahira Farooqui and Akhlaq A. Farooqui xv Contributors xvii 1 Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease 1 Suzanne M. de la Monte and Ming Tong 2 Insulin Receptor and the Pathophysiology of Alzheimer Disease 31 Johanna Zemva and Markus Schubert 3 Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease 51 Adnan Erol 4 Insulin-Leptin Signaling in the Brain 75 Vicente Barrios, Emma Burgos-Ramos, and Jes us Argente 5 The Janus Face of Insulin in Brain 85 Ana Duarte, Emanuel Candeias, S onia C. Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I. Pl acido, Maria S. Santos, Catarina R. Oliveira, and Paula I. Moreira 6 Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease 115 Maite Solas and Maria J. Ram ?rez 7 Contribution of Phospholipid, Sphingolipids, and Cholesterol-Derived Lipid Mediators in the Pathogenesis of Metabolic Syndrome and Neurological Disorders 137 Akhlaq A. Farooqui and Tahira Farooqui 8 Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated Neurotoxicity 163 Mun'delanji C. Vestergaard, Masamune Morita, Tsutomu Hamada, and Masahiro Takagi 9 Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals 179 Giulio Maria Pasinetti, Amanda Bilski, Lap Ho, Jun Wang, Mario Ferruzzi, Masahito Yamada, Kenjiro Ono, and Salvatore Mannino 10 Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction 191 Jae-Sung Lim and Hyung-Min Kwon 11 Neurochemical Linkage Among Metabolic Syndrome, Alzheimer Disease, and Depression 197 Undurti N. Das 12 Alterations in the Endocannabinoid System as a Link Between Unbalanced Energy Homeostasis, Neuroinflammation, and Neurological and Neuropsychiatric Disorders 219 Tiziana Bisogno and Vincenzo Di Marzo 13 Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides 235 George Anderson and Michael Maes 14 Binge Eating and Metabolic Syndrome 249 Ignacio J auregui-Lobera 15 Phytochemical Principles in the Traditional Indian System of Medicine Used for the Management of Metabolic Syndrome 261 Syed Ibrahim Rizvi and Neetu Mishra 16 Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome 275 Morihiro Matsuda and Iichiro Shimomura 17 The Relationship Among Obesity, Inflammation, and Insulin Resistance 283 Jean-Philippe Bastard and Bruno F`eve 18 Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome 297 Hardik Gandhi and Ramachandran Balaraman 19 Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue 311 Paolo Calabro, Enrica Golia, Valeria Maddaloni, Giuseppe Limongelli, Brunella Ziello, Fabio Fimiani, Ilaria Jane Romano, Mario Crisci, Maria Giovanna Russo, Edward T.H. Yeh, and Raffaele Calabro 20 Is Diabetes a Risk Factor for Parkinson Disease? 327 Akhlaq A. Farooqui and Tahira Farooqui 21 Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome 335 Lu Cai 22 Contributions of AMP Kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases 363 Mohamed Kodiha, Hicham Mahboubi, and Ursula Stochaj 23 A_ Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes 383 Naoyuki Sato and Ryuichi Morishita 24 In Vivo Evidence of the Convergence of Type 2 Diabetes and Alzheimer Disease 395 Sun Ah Park 25 Metabolic Syndrome and its Impact on Cardiovascular Disease 409 John A. Larry 26 Contribution of Inflammation, Adiponectin, and Obesity in Cardiovascular Diseases 423 Harald Mangge and Gunter Almer 27 Brain and Cardiovascular Diseases: Molecular Aspects 439 Ewa Szczepanska-Sadowska 28 Molecular Aspects of Dietary-Exercise Regimen for the Prevention of Metabolic Syndrome 461 Wataru Aoi 29 Ghrelin, Lipid Metabolism, and Metabolic Syndrome 475 Pablo B. Mart ?nez de Morentin, Sulay Tovar, Rub en Nogueiras, Miguel L opez, and Carlos Di eguez 30 Leptin and Cognitive Function 485 Jenni Harvey 31 Fructose, Sugar Consumption, and Metabolic Diseases 501 Virgile Lecoultre and Luc Tappy 32 Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome 515 Nathalie Castanon and Sophie Lay e 33 Summary and Perspective 529 Tahira Farooqui and Akhlaq A. Farooqui Index 539 Color plate section is located between pages 196 and 197.
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