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Acute renal injury (ARF) is a common complication in the postoperative period of liver transplantation (HT) and is associated with high morbidity and mortality rates. The current assessment of ARF diagnosis is based on changes in serum creatinine and urine output, but these parameters do not reflect real-time changes in glomerular filtration rate, as well as do not inform the type of injury, site, and severity. The aim of this manuscript is to analyze whether the evaluation of global renal function, presenting different functions of the nephron, allows the prediction - in the diagnosis of ARF - of the need for renal replacement therapy and mortality.