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Amides, especially pyridine carboxamide ligands are a class of important molecules due to its efficiency for the biological potency. Metals and metal compounds have been used in medicine for several thousands of years. These are endowed with unique characteristics that include redox activity, variable coordination modes, and reactivity towards organic substrates. Due to the low toxicity of germanium over tin, the biological activities of germanium are evident nowadays. This book is of vital information for those who work in the field of metal complexes and computational chemistry. The main content of this book is the antioxidant assay of newly synthesized germanium complexes of pyridine carboxamide ligands. An investigation of the antioxidant effect of metal chelation on pyridine carboxamide ligands are discussed and theoretically evaluated by Gaussian software to establish the mechanism of the redox activity. This book also comprises a review on recent developments in synthesis and study of properties like antioxidant activity.