MicroRNAs in Medicine (eBook, ePUB)
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MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating…mehr
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MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics. Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.
Produktdetails
- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 720
- Erscheinungstermin: 30. Oktober 2013
- Englisch
- ISBN-13: 9781118300343
- Artikelnr.: 40006498
- Verlag: John Wiley & Sons
- Seitenzahl: 720
- Erscheinungstermin: 30. Oktober 2013
- Englisch
- ISBN-13: 9781118300343
- Artikelnr.: 40006498
Dr. Charles Lawrie is Director of Oncology at the Biodonostia Institute in San Sebastián, Spain. The author of numerous research papers and book chapters, Dr. Lawrie is an Associate Editor for the Journal of Cancer Research, and serves on the editorial boards of a number of other prestigious journals including Cancers, Journal of RNAi and Gene Silencing, American Journal of Blood, and ISRN Hematology.
Foreword ix Sir David Baulcombe Preface xi Contributors xiii 1 MICRORNAS: A
BRIEF INTRODUCTION 1 Charles H. Lawrie PART I: MICRORNAS AS PHYSIOLOGICAL
REGULATORS 25 2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27
Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte 3
MICRORNAS AS REGULATORS OF IMMUNITY 41 Donald T. Gracias and Peter D.
Katsikis 4 REGULATION OF SENESCENCE BY MICRORNAS 59 Ioannis Grammatikakis
and Myriam Gorospe 5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS
IMPLICATED IN AGING 77 Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M.
Caravia, Carlos López-Otín, and Andrew J. Ramsay 6 MICRORNAS AND
HEMATOPOIESIS 91 Sukhinder K. Sandhu and Ramiro Garzon 7 MICRORNAS IN
PLATELET PRODUCTION AND ACTIVATION 101 Leonard C. Edelstein, Srikanth
Nagalla, and Paul F. Bray PART II: MICRORNAS IN INFECTIOUS DISEASE:
HOST-PATHOGEN INTERACTIONS 117 8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS
INTERACTIONS 119 Aurélie Fender and Sébastien Pfeffer 9 MICRORNA EXPRESSION
IN AVIAN HERPESVIRUSES 137 Yongxiu Yao and Venugopal Nair 10 FUNCTION OF
HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153 Natalie
L. Reynolds, Jon A. Pavelin, and Finn E. Grey 11 INVOLVEMENT OF SMALL
NON-CODING RNA IN HIV-1 INFECTION 165 Guihua Sun, John J. Rossi, and
Daniela Castanotto 12 MICRORNA IN MALARIA 183 Panote Prapansilp and Gareth
D.H. Turner PART III: CANCER 199 13 THE MICRORNA DECALOGUE OF CANCER
INVOLVEMENT 201 Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and
George A. Calin 14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223 Eva E.
Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and
Pedro P. Medina 15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245
Yolanda Sánchez and Maite Huarte 16 REGULATION OF HYPOXIA RESPONSES BY
MICRORNA EXPRESSION 267 Carme Camps, Adrian L. Harris, and Jiannis
Ragoussis 17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287
Claudia Piovan and Marilena V. Iorio 18 MICRORNAS IN HUMAN PROSTATE CANCER:
FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311 Mustafa Ozen and Omer
Faruk Karatas 19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329
Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel 20 GENETIC VARIATIONS IN
MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER
SUSCEPTIBILITY AND SURVIVAL 343 Ming Yang and Dongxin Lin 21 MICRORNA IN
MYELOPOIESIS AND MYELOID DISORDERS 353 Sara E. Meyer and H. Leighton Grimes
22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC
LEUKEMIA 371 Xabier Agirre and Felipe Prósper 23 ROLE OF MIRNAS IN THE
PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383 Veronica Balatti, Yuri
Pekarsky, Lara Rizzotto, and Carlo M. Croce 24 MICRORNA IN B-CELL
NON-HODGKIN'S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403
Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris 25 MICRORNAS IN
DIFFUSE LARGE B-CELL LYMPHOMA 419 Izidore S. Lossos and Alvaro J. Alencar
26 THE ROLE OF MICRORNAS IN HODGKIN'S LYMPHOMA 435 Wouter Plattel, Joost
Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg 27 MICRORNA
EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449 Cornelis P. Tensen PART IV:
HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463 28 MICRORNAS AND
HEREDITARY DISORDERS 465 Matías Morín and Miguel A. Moreno-Pelayo 29
MICRORNAS AND CARDIOVASCULAR DISEASES 477 Koh Ono 30 MICRORNAS AND DIABETES
495 Romano Regazzi 31 MICRORNAS IN LIVER DISEASES 509 Patricia
Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M.
Banales 32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523 Andreas Junker 33
THE ROLE OF MICRORNAS IN ALZHEIMER'S DISEASE 539 Shahar Barbash and Hermona
Soreq 34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553 Aoife
Kearney, Javier A. Bravo, and Timothy G. Dinan PART V: CIRCULATING
MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567 35 CIRCULATING
MICRORNAS AS NON-INVASIVE BIOMARKERS 569 Heidi Schwarzenbach and Klaus
Pantel 36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589 Kasey C. Vickers
37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND
METASTASIS IN RENAL CARCINOMA 607 Federica Collino, Cristina Grange, and
Giovanni Camussi PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT
PERSPECTIVES AND FUTURE DIRECTIONS 623 38 MICRORNA REGULATION OF CANCER
STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625 Can
Liu and Dean G. Tang 39 THERAPEUTIC MODULATION OF MICRORNAS 639 Achim
Aigner and Hannelore Dassow 40 LOCKED NUCLEIC ACIDS AS MICRORNA
THERAPEUTICS 663 Henrik Ørum Index 673
BRIEF INTRODUCTION 1 Charles H. Lawrie PART I: MICRORNAS AS PHYSIOLOGICAL
REGULATORS 25 2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27
Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte 3
MICRORNAS AS REGULATORS OF IMMUNITY 41 Donald T. Gracias and Peter D.
Katsikis 4 REGULATION OF SENESCENCE BY MICRORNAS 59 Ioannis Grammatikakis
and Myriam Gorospe 5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS
IMPLICATED IN AGING 77 Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M.
Caravia, Carlos López-Otín, and Andrew J. Ramsay 6 MICRORNAS AND
HEMATOPOIESIS 91 Sukhinder K. Sandhu and Ramiro Garzon 7 MICRORNAS IN
PLATELET PRODUCTION AND ACTIVATION 101 Leonard C. Edelstein, Srikanth
Nagalla, and Paul F. Bray PART II: MICRORNAS IN INFECTIOUS DISEASE:
HOST-PATHOGEN INTERACTIONS 117 8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS
INTERACTIONS 119 Aurélie Fender and Sébastien Pfeffer 9 MICRORNA EXPRESSION
IN AVIAN HERPESVIRUSES 137 Yongxiu Yao and Venugopal Nair 10 FUNCTION OF
HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153 Natalie
L. Reynolds, Jon A. Pavelin, and Finn E. Grey 11 INVOLVEMENT OF SMALL
NON-CODING RNA IN HIV-1 INFECTION 165 Guihua Sun, John J. Rossi, and
Daniela Castanotto 12 MICRORNA IN MALARIA 183 Panote Prapansilp and Gareth
D.H. Turner PART III: CANCER 199 13 THE MICRORNA DECALOGUE OF CANCER
INVOLVEMENT 201 Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and
George A. Calin 14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223 Eva E.
Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and
Pedro P. Medina 15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245
Yolanda Sánchez and Maite Huarte 16 REGULATION OF HYPOXIA RESPONSES BY
MICRORNA EXPRESSION 267 Carme Camps, Adrian L. Harris, and Jiannis
Ragoussis 17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287
Claudia Piovan and Marilena V. Iorio 18 MICRORNAS IN HUMAN PROSTATE CANCER:
FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311 Mustafa Ozen and Omer
Faruk Karatas 19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329
Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel 20 GENETIC VARIATIONS IN
MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER
SUSCEPTIBILITY AND SURVIVAL 343 Ming Yang and Dongxin Lin 21 MICRORNA IN
MYELOPOIESIS AND MYELOID DISORDERS 353 Sara E. Meyer and H. Leighton Grimes
22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC
LEUKEMIA 371 Xabier Agirre and Felipe Prósper 23 ROLE OF MIRNAS IN THE
PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383 Veronica Balatti, Yuri
Pekarsky, Lara Rizzotto, and Carlo M. Croce 24 MICRORNA IN B-CELL
NON-HODGKIN'S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403
Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris 25 MICRORNAS IN
DIFFUSE LARGE B-CELL LYMPHOMA 419 Izidore S. Lossos and Alvaro J. Alencar
26 THE ROLE OF MICRORNAS IN HODGKIN'S LYMPHOMA 435 Wouter Plattel, Joost
Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg 27 MICRORNA
EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449 Cornelis P. Tensen PART IV:
HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463 28 MICRORNAS AND
HEREDITARY DISORDERS 465 Matías Morín and Miguel A. Moreno-Pelayo 29
MICRORNAS AND CARDIOVASCULAR DISEASES 477 Koh Ono 30 MICRORNAS AND DIABETES
495 Romano Regazzi 31 MICRORNAS IN LIVER DISEASES 509 Patricia
Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M.
Banales 32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523 Andreas Junker 33
THE ROLE OF MICRORNAS IN ALZHEIMER'S DISEASE 539 Shahar Barbash and Hermona
Soreq 34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553 Aoife
Kearney, Javier A. Bravo, and Timothy G. Dinan PART V: CIRCULATING
MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567 35 CIRCULATING
MICRORNAS AS NON-INVASIVE BIOMARKERS 569 Heidi Schwarzenbach and Klaus
Pantel 36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589 Kasey C. Vickers
37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND
METASTASIS IN RENAL CARCINOMA 607 Federica Collino, Cristina Grange, and
Giovanni Camussi PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT
PERSPECTIVES AND FUTURE DIRECTIONS 623 38 MICRORNA REGULATION OF CANCER
STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625 Can
Liu and Dean G. Tang 39 THERAPEUTIC MODULATION OF MICRORNAS 639 Achim
Aigner and Hannelore Dassow 40 LOCKED NUCLEIC ACIDS AS MICRORNA
THERAPEUTICS 663 Henrik Ørum Index 673
Foreword ix Sir David Baulcombe Preface xi Contributors xiii 1 MICRORNAS: A
BRIEF INTRODUCTION 1 Charles H. Lawrie PART I: MICRORNAS AS PHYSIOLOGICAL
REGULATORS 25 2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27
Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte 3
MICRORNAS AS REGULATORS OF IMMUNITY 41 Donald T. Gracias and Peter D.
Katsikis 4 REGULATION OF SENESCENCE BY MICRORNAS 59 Ioannis Grammatikakis
and Myriam Gorospe 5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS
IMPLICATED IN AGING 77 Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M.
Caravia, Carlos López-Otín, and Andrew J. Ramsay 6 MICRORNAS AND
HEMATOPOIESIS 91 Sukhinder K. Sandhu and Ramiro Garzon 7 MICRORNAS IN
PLATELET PRODUCTION AND ACTIVATION 101 Leonard C. Edelstein, Srikanth
Nagalla, and Paul F. Bray PART II: MICRORNAS IN INFECTIOUS DISEASE:
HOST-PATHOGEN INTERACTIONS 117 8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS
INTERACTIONS 119 Aurélie Fender and Sébastien Pfeffer 9 MICRORNA EXPRESSION
IN AVIAN HERPESVIRUSES 137 Yongxiu Yao and Venugopal Nair 10 FUNCTION OF
HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153 Natalie
L. Reynolds, Jon A. Pavelin, and Finn E. Grey 11 INVOLVEMENT OF SMALL
NON-CODING RNA IN HIV-1 INFECTION 165 Guihua Sun, John J. Rossi, and
Daniela Castanotto 12 MICRORNA IN MALARIA 183 Panote Prapansilp and Gareth
D.H. Turner PART III: CANCER 199 13 THE MICRORNA DECALOGUE OF CANCER
INVOLVEMENT 201 Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and
George A. Calin 14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223 Eva E.
Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and
Pedro P. Medina 15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245
Yolanda Sánchez and Maite Huarte 16 REGULATION OF HYPOXIA RESPONSES BY
MICRORNA EXPRESSION 267 Carme Camps, Adrian L. Harris, and Jiannis
Ragoussis 17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287
Claudia Piovan and Marilena V. Iorio 18 MICRORNAS IN HUMAN PROSTATE CANCER:
FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311 Mustafa Ozen and Omer
Faruk Karatas 19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329
Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel 20 GENETIC VARIATIONS IN
MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER
SUSCEPTIBILITY AND SURVIVAL 343 Ming Yang and Dongxin Lin 21 MICRORNA IN
MYELOPOIESIS AND MYELOID DISORDERS 353 Sara E. Meyer and H. Leighton Grimes
22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC
LEUKEMIA 371 Xabier Agirre and Felipe Prósper 23 ROLE OF MIRNAS IN THE
PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383 Veronica Balatti, Yuri
Pekarsky, Lara Rizzotto, and Carlo M. Croce 24 MICRORNA IN B-CELL
NON-HODGKIN'S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403
Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris 25 MICRORNAS IN
DIFFUSE LARGE B-CELL LYMPHOMA 419 Izidore S. Lossos and Alvaro J. Alencar
26 THE ROLE OF MICRORNAS IN HODGKIN'S LYMPHOMA 435 Wouter Plattel, Joost
Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg 27 MICRORNA
EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449 Cornelis P. Tensen PART IV:
HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463 28 MICRORNAS AND
HEREDITARY DISORDERS 465 Matías Morín and Miguel A. Moreno-Pelayo 29
MICRORNAS AND CARDIOVASCULAR DISEASES 477 Koh Ono 30 MICRORNAS AND DIABETES
495 Romano Regazzi 31 MICRORNAS IN LIVER DISEASES 509 Patricia
Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M.
Banales 32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523 Andreas Junker 33
THE ROLE OF MICRORNAS IN ALZHEIMER'S DISEASE 539 Shahar Barbash and Hermona
Soreq 34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553 Aoife
Kearney, Javier A. Bravo, and Timothy G. Dinan PART V: CIRCULATING
MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567 35 CIRCULATING
MICRORNAS AS NON-INVASIVE BIOMARKERS 569 Heidi Schwarzenbach and Klaus
Pantel 36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589 Kasey C. Vickers
37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND
METASTASIS IN RENAL CARCINOMA 607 Federica Collino, Cristina Grange, and
Giovanni Camussi PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT
PERSPECTIVES AND FUTURE DIRECTIONS 623 38 MICRORNA REGULATION OF CANCER
STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625 Can
Liu and Dean G. Tang 39 THERAPEUTIC MODULATION OF MICRORNAS 639 Achim
Aigner and Hannelore Dassow 40 LOCKED NUCLEIC ACIDS AS MICRORNA
THERAPEUTICS 663 Henrik Ørum Index 673
BRIEF INTRODUCTION 1 Charles H. Lawrie PART I: MICRORNAS AS PHYSIOLOGICAL
REGULATORS 25 2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27
Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte 3
MICRORNAS AS REGULATORS OF IMMUNITY 41 Donald T. Gracias and Peter D.
Katsikis 4 REGULATION OF SENESCENCE BY MICRORNAS 59 Ioannis Grammatikakis
and Myriam Gorospe 5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS
IMPLICATED IN AGING 77 Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M.
Caravia, Carlos López-Otín, and Andrew J. Ramsay 6 MICRORNAS AND
HEMATOPOIESIS 91 Sukhinder K. Sandhu and Ramiro Garzon 7 MICRORNAS IN
PLATELET PRODUCTION AND ACTIVATION 101 Leonard C. Edelstein, Srikanth
Nagalla, and Paul F. Bray PART II: MICRORNAS IN INFECTIOUS DISEASE:
HOST-PATHOGEN INTERACTIONS 117 8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS
INTERACTIONS 119 Aurélie Fender and Sébastien Pfeffer 9 MICRORNA EXPRESSION
IN AVIAN HERPESVIRUSES 137 Yongxiu Yao and Venugopal Nair 10 FUNCTION OF
HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153 Natalie
L. Reynolds, Jon A. Pavelin, and Finn E. Grey 11 INVOLVEMENT OF SMALL
NON-CODING RNA IN HIV-1 INFECTION 165 Guihua Sun, John J. Rossi, and
Daniela Castanotto 12 MICRORNA IN MALARIA 183 Panote Prapansilp and Gareth
D.H. Turner PART III: CANCER 199 13 THE MICRORNA DECALOGUE OF CANCER
INVOLVEMENT 201 Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and
George A. Calin 14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223 Eva E.
Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and
Pedro P. Medina 15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245
Yolanda Sánchez and Maite Huarte 16 REGULATION OF HYPOXIA RESPONSES BY
MICRORNA EXPRESSION 267 Carme Camps, Adrian L. Harris, and Jiannis
Ragoussis 17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287
Claudia Piovan and Marilena V. Iorio 18 MICRORNAS IN HUMAN PROSTATE CANCER:
FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311 Mustafa Ozen and Omer
Faruk Karatas 19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329
Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel 20 GENETIC VARIATIONS IN
MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER
SUSCEPTIBILITY AND SURVIVAL 343 Ming Yang and Dongxin Lin 21 MICRORNA IN
MYELOPOIESIS AND MYELOID DISORDERS 353 Sara E. Meyer and H. Leighton Grimes
22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC
LEUKEMIA 371 Xabier Agirre and Felipe Prósper 23 ROLE OF MIRNAS IN THE
PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383 Veronica Balatti, Yuri
Pekarsky, Lara Rizzotto, and Carlo M. Croce 24 MICRORNA IN B-CELL
NON-HODGKIN'S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403
Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris 25 MICRORNAS IN
DIFFUSE LARGE B-CELL LYMPHOMA 419 Izidore S. Lossos and Alvaro J. Alencar
26 THE ROLE OF MICRORNAS IN HODGKIN'S LYMPHOMA 435 Wouter Plattel, Joost
Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg 27 MICRORNA
EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449 Cornelis P. Tensen PART IV:
HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463 28 MICRORNAS AND
HEREDITARY DISORDERS 465 Matías Morín and Miguel A. Moreno-Pelayo 29
MICRORNAS AND CARDIOVASCULAR DISEASES 477 Koh Ono 30 MICRORNAS AND DIABETES
495 Romano Regazzi 31 MICRORNAS IN LIVER DISEASES 509 Patricia
Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M.
Banales 32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523 Andreas Junker 33
THE ROLE OF MICRORNAS IN ALZHEIMER'S DISEASE 539 Shahar Barbash and Hermona
Soreq 34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553 Aoife
Kearney, Javier A. Bravo, and Timothy G. Dinan PART V: CIRCULATING
MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567 35 CIRCULATING
MICRORNAS AS NON-INVASIVE BIOMARKERS 569 Heidi Schwarzenbach and Klaus
Pantel 36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589 Kasey C. Vickers
37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND
METASTASIS IN RENAL CARCINOMA 607 Federica Collino, Cristina Grange, and
Giovanni Camussi PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT
PERSPECTIVES AND FUTURE DIRECTIONS 623 38 MICRORNA REGULATION OF CANCER
STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625 Can
Liu and Dean G. Tang 39 THERAPEUTIC MODULATION OF MICRORNAS 639 Achim
Aigner and Hannelore Dassow 40 LOCKED NUCLEIC ACIDS AS MICRORNA
THERAPEUTICS 663 Henrik Ørum Index 673