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This unique text/reference describes the state of the art in computational gene finding, with a particular focus on comparative approaches. Providing both an overview of the various methods that are applied in the field, and a concise guide on how computational gene finders are built, the book covers a broad range of topics from probability theory, statistics, information theory, optimization theory and numerical analysis. Features: describes how algorithms and sequence alignments can be combined to improve the accuracy of gene finding; introduces the basic biological terms and concepts in…mehr

Produktbeschreibung
This unique text/reference describes the state of the art in computational gene finding, with a particular focus on comparative approaches. Providing both an overview of the various methods that are applied in the field, and a concise guide on how computational gene finders are built, the book covers a broad range of topics from probability theory, statistics, information theory, optimization theory and numerical analysis. Features: describes how algorithms and sequence alignments can be combined to improve the accuracy of gene finding; introduces the basic biological terms and concepts in genetics, and provides an historical overview of algorithm development; explores the gene features most commonly captured by a computational gene model; discusses the algorithms most commonly used for single-species gene finding; investigates approaches to pairwise and multiple sequence alignments; explains the basics of parameter training; illustrates how to implement a comparative gene finder.

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GB, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 30.01.2010
  • Englisch
  • ISBN-13: 9781849961042
  • Artikelnr.: 37355281
Inhaltsangabe
Introduction

Single Species Gene Finding

Sequence Alignment

Comparative Gene Finding

Gene Structure Submodels

Parameter Training

Implementation of a Comparative Gene Finder

Annotation Pipelines for Next Generation Sequencing Projects
Rezensionen
"The structure of the book mirrors the learning steps for understanding how to perform gene finding. ... Its target audience is mainly post-graduate researchers or established researchers with a background in mathematics or statistics applied in bioinformatics who need a thorough yet concise overview of this field." (Irina Ioana Mohorianu, zbMATH 1350.92001, 2017)

"It skillfully introduces readers to a difficult subject, while at the same time motivating them to enter this very important area. ... It is best suited for a graduate course or as an introduction for researchers not familiar with this field. ... this is an excellent introduction to comparative gene finding. ... I especially recommend this book to any computer scientist with an interest in current problems in bioinformatics." (Burkhard Englert, Computing Reviews, December, 2015)