Bioinformatics and the Cell (eBook, PDF) - Xia, Xuhua
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The many books that have been written on bioinformatics tend to fall on two extremes: books that feature computational details with a great deal of mathematics, for computational scientists and mathematicians, or books that treat bioinformatics mostly as a giant black box, for biologists. Previous books written on bioinformatics often have limited contribution to creating interdisciplinary scientists needed in modern biological and biomedical sciences. This book aims to render both mathematical equations and biology to numbers, to help truly interdisciplinary scientists. Although the book…mehr

Produktbeschreibung
The many books that have been written on bioinformatics tend to fall on two extremes: books that feature computational details with a great deal of mathematics, for computational scientists and mathematicians, or books that treat bioinformatics mostly as a giant black box, for biologists. Previous books written on bioinformatics often have limited contribution to creating interdisciplinary scientists needed in modern biological and biomedical sciences. This book aims to render both mathematical equations and biology to numbers, to help truly interdisciplinary scientists. Although the book covers bioinformatics methods at a level more advanced than most other bioinformatics books, the extensive numerical illustration of these methods should make it accessible to most senior undergraduate students and graduate students majoring in science and software engineering. Nearly all algorithms in the book are implemented in a free and user-friendly computer program (DAMBE). TOC:BLAST and FASTA.- Sequence Alignment.- Contig Assembly.- DNA Replication and Viral Evolution.- Gene and Motif Prediction.- Hidden Markov Models.- Gibbs Sampler.- Bioinformatics and Vertebrate Mitochondria.- Characterizing Translation Efficiency.- Protein Isoelectric Point.- Bioinformatics and Two-Dimensional Protein Separation.- Self-Organizing Map and Other Clustering Algorithms.- Molecular Phylogenetics.- Fundamentals of Proteomics.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 24.04.2007
  • Englisch
  • ISBN-13: 9780387713373
  • Artikelnr.: 37286968
Autorenporträt
Dr. Xuhua Xia obtained his PhD in population biology at University of Western Ontario in 1990 and made his entry into molecular evolution and phylogenetics at University of Washington in 1993. He was recruited by University of Hong Kong in 1996 as an assistant professor, and served as a senior scientist and the founding head of the Bioinformatics Laboratory of HKU-Pasteur Research Centre. Dr. Xia joined University of Ottawa in 2002 where he is cross-appointed to both Biology Department and the School of Information Technology Engineering. He is an active member in the Center for Advanced Research in Environmental Genomics and the Ottawa Institute of Systems Biology. His web site is at http://dambe.bio.uottawa.ca.

Inhaltsangabe
Blast and Fasta.- Sequence alignment.- Contig assembly.- DNA replication and viral evolution.- Gene and motif prediction.- Hidden Markov Models.- Gibbs Sampler.- Bioinformatics and vertebrate mitochondria.- Characterizing translation efficiency.- Protein isoelectric point.- Bioinformatics and Two-Dimensional Protein Separation.- Self-Organizing Map and other clustering Algorithms.- Molecular Phylogenetics.- Fundamentals of Proteomics.
Rezensionen
From the reviews:

"In this book the author makes an 'effort to render both mathematical equations and biology to numbers'. ... he works out a lot of illustrative examples to make biologists understand the mathematics and computational scientists understand the biology of a wide range of problems in bioinformatics. ... The book is addressed to graduate students majoring in sciences and software engineering. Biologists with a sound knowledge of computer programming should be able to implement the presented algorithms in their own programs." (Wiebke Werft, Zentralblatt MATH, Vol. 1166, 2009)