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Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or…mehr

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Produktbeschreibung
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. TOC:The Reelin Gene and Its Functions in Brain Development.- Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An Overview.- Chemistry of Reelin.- The C-terminal region of Reelin: structure and function.- Crystal Structure of Reelin Repeats.- Comparative Anatomy and Evolutionary Roles of Reelin.- Reelin / Dab1 Signaling in the Developing Cerebral Cortex.- Ultrastructural Localization of Reelin.- Reelin and Cyclin-Dependent Kinase 5.- Reelin and the Cerebellum.- Reelin and Radial Glial Cells.- Reelin and Cognition.- Protein Kinases and Signaling Pathways that are Activated by Reelin.- The Relationship of Oxytocin and Reelin in the Brain.- Reelin and Thyroid Hormone.- A Tale of Two Genes: Reelin and BDNF.- Reelin, Liver, and Lymphatics.- Reelin and Cajal-Retzius Cells.- Reelin and Odontogenesis.- Homozygous and Heterozygous Reeler Mouse Mutants.- Reelin and Lissencephaly.- The Role of Reelin in Etiology and Treatment of Psychiatric Disorders.- Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia.- Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder.- Reelin Gene Polymorphisms in Autistic Disorder.- Alzheimer's and Reelin.- Reelin and Stroke.- Reelin and Pancreatic Cancer.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 04.06.2008
  • Englisch
  • ISBN-13: 9780387767611
  • Artikelnr.: 37285043
Inhaltsangabe
The Reelin Gene and Its Functions in Brain Development
Cheng-Chiu Huang, MS
Gabriella D'Arcangelo, PhD

Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An Overview

Dr. Hans H. Bock
Prof. Dr. Joachim HerzChemistry of Reelin

Yves Jossin, PhD

The C-terminal region of Reelin: structure and function

Mitsuharu Hattori, PhD

Crystal Structure of Reelin Repeats

Junichi Takagi, PhD

Comparative Anatomy and Evolutionary Roles of Reelin

Gundela Meyer, MD, PhD

Reelin / Dab1 Signaling in the Developing Cerebral Cortex

Eric C. Olson, PhD
Christopher A. Walsh, MD, PhD

Ultrastructural Localization of Reelin

Rosalinda C. Roberts, PhD
Emma Perez-Costas, PhD

Reelin and Cyclin-Dependent Kinase 5

Toshio Ohshima, MD, PhD

Reelin and the Cerebellum

Robert F. Hevner, MD, PhD

Reelin and Radial Glial Cells

Eckart Forster, PhD
Shanting Zhao, MD
Michael Frotscher, MD

Reelin and Cognition

Shenfeng Qiu, PhD
Edwin John Weeber, PhD

Protein Kinases and Signaling Pathwaysthat are Activated by Reelin

Jonathan A. Cooper, PhD
Nathaniel S. Allen, BS
Libing Feng, PhD

The Relationship of Oxytocin and Reelin in the Brain

George D. Pappas, PhD
C. Sue Carter, PhD

Reelin and Thyroid Hormone

Manuel Alvarez-Dolado, PhD

A Tale of Two Genes: Reelin and BDNF

Thomas Ringstedt, PhD

Reelin, Liver, and Lymphatics

BrigitteSamama, PhD
Nelly Boehm, MD, PhD

Reelin and Cajal-Retzius Cells

Jean-Marc Mienville, PhD

Reelin and Odontogenesis

Francoise Bleicher
Henry Magloire
Marie-Lise Couble
Jean-Christophe Maurin

Homozygous and Heterozygous Reeler Mouse Mutants

Patricia Tueting, PhD
Graziano Pinna, PhD
Erminio Costa, MD

Reelin and Lissencephaly

Elena Parrini, PhD
Renzo Guerrini, MD

The Role of Reelin in Etiology and Treatment of Psychiatric Disorders

S. Hossein Fatemi, MD, PhD
Teri J. Reutiman, BA
Timothy D. Folsom, MS

Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia

Erminio Costa, MD
Ying Chen, PhD
Erbo Dong PhD
Dennis R. Grayson, PhD
Alessandro Guidotti, MD
Marin Veldic, MD

Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder

Hamid Mostafavi Abdolmaleky, MD
Cassandra L. Smith PhD
Jin-Rong Zhou, PhD
Sam Thiagalingam, PhD

Reelin Gene Polymorphisms in Autistic Disorder

Carla Lintas PhD
Antonio Maria Persico, MD

Alzheimer's and Reelin

Arancha Botella-Lopez, BS
Javier Saez-Valero, PhD

Reelin and Stroke

Kunlin Jin, MD, PhD

Reelin and Pancreatic Cancer
Kimberly Walter, BS
Michael Goggins, MD
Rezensionen
From the reviews: "The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. ... The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. ... This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody's Review Service, July, 2009) "The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. ... The book consists of 28 chapters presented by international group of experts. ... book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders." (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)