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Post Genomics Drug Discovery and Research explores and discussessome of the most important topics in post-genomics life andbiopharmaceutical sciences. It provides an introduction to thefield, outlining examples of many techniques currently used, aswell as those still under development, which are important for theresearch of biopharmaceutical discovery in the post-genomics era. * Integrates several developing and cutting-edge technologies andmethods like bioinformatics, experimental therapeutics, andmolecular recognition * Includes discussion on topics such as: computer-aided liganddesign;…mehr

Produktbeschreibung
Post Genomics Drug Discovery and Research explores and discussessome of the most important topics in post-genomics life andbiopharmaceutical sciences. It provides an introduction to thefield, outlining examples of many techniques currently used, aswell as those still under development, which are important for theresearch of biopharmaceutical discovery in the post-genomics era. * Integrates several developing and cutting-edge technologies andmethods like bioinformatics, experimental therapeutics, andmolecular recognition * Includes discussion on topics such as: computer-aided liganddesign; peptide and protein chemistry and synthesis; synthesis ofactive natural products; and the use of emerging technologies likeproteomics, nanotechnology, or bioengineering.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 464
  • Erscheinungstermin: 16.08.2007
  • Englisch
  • ISBN-13: 9780470131855
  • Artikelnr.: 37290911
Autorenporträt
Ziwei Huang, PHD, is Professor at the Burnham Institute for Medical Research and Adjunct Professor at the University of California at San Diego. He was previously Assistant Professor at Thomas Jefferson University in Philadelphia (1995-2000) and tenured Associate Professor at the University of Illinois at Urbana-Champaign (2000-2004). The author or coauthor of numerous publications and patents, Professor Huang has conducted research in cross-disciplinary areas related to drug discovery, medicinal chemistry, biochemistry, and chemical biology and has developed novel therapeutic agents and research probes for treating or studying human diseases. He has organized many international conferences and workshops in drug discovery research in America and Asia. Additionally, Professor Huang has had close interaction with the biotechnology and pharmaceutical industries as the founder of several biopharmaceutical companies and consultant for many major biotechnology and pharmaceutical companies.
Inhaltsangabe
FOREWORD.
INTRODUCTION.
CONTRIBUTORS.
PART I. COMPUTATIONAL AND STRUCTURAL APPROACHES IN DRUG DISCOVERY.
CHAPTER 1. MOLECULAR DOCKING AND STRUCTURE-BASED DESIGN.
CHAPTER 2. RECENT ADVANCES IN DRUG DISCOVERY RESEARCH USING STRUCTURE-BASED VIRTUAL SCREENING TECHNIQUES: EXAMPLES OF SUCCESS FOR DIVERSE PROTEIN TARGETS.
CHAPTER 3. VIRTUAL SCREENING IN DRUG DISCOVERY.
CHAPTER 4. COMPUTER-AIDED DRUG DESIGN.
CHAPTER 5. FOCUSED LIBRARY DESIGN BASED ON HIT AND TARGET STRUCTURES: METHOD AND APPLICATION IN DRUG DISCOVERY.
PART II. CHEMICAL AND SYNTHETIC APPROACHES IN DRUG DISCOVERY.
CHAPTER 6. BEYOND NATURAL PRODUCTS: SYNTHETIC ANALOGUES OF BRYOSTATIN 1.
CHAPTER 7. THE PROMISES AND PITFALLS OF SMALL-MOLECULE INHIBITION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG).
CHAPTER 8. CYCLIC ADP-RIBOSE ANALOGUES WITH MINIMAL STRUCTURE: SYNTHESIS AND CALCIUM-RELEASE ACTIVITY.
CHAPTER 9. EVALUATION OF NEUROIMMUNOPHILIN LIGANDS.
CHAPTER 10. CHIRAL DRUGS AND THE ASSOCIATED ASYMMETRIC SYNTHESIS.
CHAPTER 11. ALPHA-HELIX MIMETICS IN DRUG DISCOVERY 281
CHAPTER 12. BASIC AND TRANSLATIONAL RESEARCH OF CHEMOKINE LIGANDS AND RECEPTORS AND DEVELOPMENT OF NOVEL THERAPEUTICS.
CHAPTER 13. RESEARCH PROGRESS IN PROTEIN POST-TRANSLATIONAL MODIFICATION.
CHAPTER 14. CONTROLLED RELEASE OFANTIBIOTICS ENCAPSULATED IN NANOPOROUS SOL-GEL MATERIALS WITH TUNABLE PORE PARAMETERS.
PART III. BIOLOGICAL APPROACHES AND TRANSLATIONAL RESEARCH IN DRUG DISCOVERY.
CHAPTER 15. RETINOIC ACID AND ARSENIC TRIOXIDE TREATMENT IN ACUTE PROMYELOCYTIC LEUKEMIA: A MODEL OF ONCOPROTEIN TARGETED THERAPY.
CHAPTER 16. 2-CHLORODEOXYADENOSINE.
CHAPTER 17. APOPTOSIS-BASED DRUG DISCOVERY FOR CANCER.
CHAPTER 18. MECHANISM-BASED DEVELOPMENT OF MEMANTINE AS A THERAPEUTIC AGENT IN TREATING ALZHEIMER'S DISEASE AND OTHER NEUROLOGIC DISORDERS: LOW-AFFINITY, UNCOMPETITIVE ANTAGONISM WITH FAST OFF-RATE.
CHAPTER 19. BRIDGING BENCH TO CLINIC: ROLES OFANIMAL MODELS FOR POST-GENOMICS DRUG DISCOVERY ON METABOLIC DISEASES.
CHAPTER 20. STEM CELL RESEARCH AND APPLICATIONS FOR HUMAN THERAPIES.
INDEX.
Rezensionen
"A valuable resource for scientists ... Chapters in each section are filled with in-depth biological and chemical data and, importantly, include worked examples of drugs identified from these approaches." ( The Biochemist , October 2008)
"..the book achieves the objective of the Editor in providing a useful tool and reference for scientists concerned with state-of-the-art postgenomic drug discovery...this book will be of interest to medicinal chemistry, as well as to other concerned with developing new drug products." ( Journal of Medicinal Chemistry , January 2008)