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This book provides a comprehensive analysis of implications of DNA methylation on cancer diagnosis and cancer therapy. This unique volume focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Key features of this book include discussions of the following topics: The molecular machinery responsible for DNA…mehr

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Produktbeschreibung
This book provides a comprehensive analysis of implications of DNA methylation on cancer diagnosis and cancer therapy. This unique volume focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Key features of this book include discussions of the following topics: The molecular machinery responsible for DNA methylation and their impact on gene expression and tumorigenesis. The emerging relation between DNA methylation and chromatin modifying proteins. How the relationship between DNA methylation and chromatin modifying proteins might clarify the mechanisms and therapeutic implications of aberrant DNA methylation in cancer. Illustrations of the diagnostic potential of methylation in cancer and novel tools for using methylation profiling of cancers. The therapeutic potential of the DNA methylation machinery and novel attempts to target the DNA methylation enzymes in anticancer therapy. This book will be of interest to a wide audience, including oncologists, researchers and clinicians, and graduate students in the fields of oncology, molecular biology, and cancer therapy, as well as researchers and decision-makers in industry focusing on anticancer drugs and diagnosis. TOC:DNA Methylation: Three Decades in Search of Function.- Epigenetic Mechanisms of Gene Regulation: Relationships between DNA Methylation, Histone Modification, and Chromatin Structure.- DNA Hypo- vs. Hypermethylation in Cancer: Tumor Specificity, Tumor Progression, and Therapeutic Implications.- DNA Methylation in Urological Cancers.- DNA Methylation in Colorectal Cancer.- CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer: Concepts, Methodologies and Uses.- The Loss of Methyl Groups in DNA of Tumor Cells and Tissues: The Immunochemical Approach.- Identifying Clinicopathological Association of DNA Hypermethylation in Cancers Using CpG Island Microarrays.- Methylation Analysis in Cancer: (Epi)Genomic Fast Track from Discovery to Clinical Routine.- Regulation of DNA Methyltransferases in Cancer.- Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation.- The Role of Active Demethylation in Cancer and Its Therapeutic Potential.- Purine Analogues and Their Role in Methylation and Cancer Chemotherapy.- DNA Methyltransferase Inhibitors: Paving the Way for Epigenetic Cancer Therapeutics.- Preclinical and Clinical Studies on 5-Aza-2'-Deoxycytidine, a Potent Inhibitor of DNA Methylation, in Cancer Therapy.- Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense.-Epilogue.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 03.04.2007
  • Englisch
  • ISBN-13: 9780387274430
  • Artikelnr.: 37285978
Autorenporträt
Moshe Szyf, McGill University, Montreal, QC, Canada
Inhaltsangabe
Preface ................................................................................................ xiii 1. DNA Methylation: Three Decades in Search of Function ...................... 1 Aharon Razin DNA Methylation in Prokaryotes.......................................................... 1 DNA Methylation in Eukaryotes ........................................................... 2 Methylation and Embryogenesis ............................................................ 2 DNA Methylation and Imprinting ........................................................ 4 DNA Methylation in Gene Silencing .................................................... 4 DNA Methylation and Disease.............................................................. 5 Reflections ............................................................................................. 8 2. Epigenetic Mechanisms of Gene Regulation: Relationships between DNA Methylation
Histone Modification
and Chromatin Structure ..................................................................... 13 Keith D. Robertson The Mammalian DNA Methyltransferases (DNMTs) ......................... 14 Interaction between DNMTs and Other Proteins ............................... 16 DNA Methylation and DNA Replication ............................................ 20 Links between DNA Methylation and Histone Modification .............. 20 DNA Methylation and Histone Methylation ...................................... 21 DNMTs As Transcriptional Corepressors ........................................... 22 DNA Methylation and Chromatin Remodeling .................................. 24 3. DNA Hypo- vs. Hypermethylation in Cancer: Tumor Specificity
Tumor Progression
and Therapeutic Implications .............................. 31 Melanie Ehrlich and GuanchaoJiang Are There Tumor-Specific DNA Hypomethylation Profiles Like the Tumor-Specific DNA Hypermethylation Profiles? .................... 32 Is There a Relationship between Cancer-Associated DNA
Hypomethylation and DNA Hypermethylation? ............................. 34 Is DNA Hypomethylation
Like DNA Hypermethylation
Sometimes Associated with Tumor Progression? .............................. 35 Might There Be Deleterious Consequences of Introducing DNA Hypomethylation in the Genome As a Cancer Therapy? ................. 37 4. DNA Methylation in Urological Cancers ............................................. 42 Wolfgang A. Schulz and Hans-Helge Seifert An Overview of Urological Cancers ..................................................... 42 A Description of DNA Methylation Changes in Urological Malignancies .............................................................. 44 A Global View of DNA Methylation Alterations in Urological Cancers ...................................................................... 47 Causes of Altered DNA Methylation in Urological Cancers ................ 48 Consequences of Altered DNA Methylation in Urological Cancers ....... 50 DNA Methylation in Diagnosis and Therapy of Urological Cancers ...... 51 Szyf MIU Front Matter 9/15/04
2:29 PM 5 5. DNA Methylation in Colorectal Cancer ............................................... 59 Jeremy R. Jass
Vicki L.J. Whitehall
Joanne Young and Barbara A. Leggett Relevance of Familial Models of Colorectal Cancer to Sporadic Neoplasia ...................................................................... 60 DNA Microsatellite Instability ............................................................ 60 Mechanisms Underlying Microsatellite Instability in Colorectal Cancer .........................

Preface ................................................................................................ xiii 1. DNA Methylation: Three Decades in Search of Function ...................... 1 Aharon Razin DNA Methylation in Prokaryotes.......................................................... 1 DNA Methylation in Eukaryotes ........................................................... 2 Methylation and Embryogenesis ............................................................ 2 DNA Methylation and Imprinting ........................................................ 4 DNA Methylation in Gene Silencing .................................................... 4 DNA Methylation and Disease.............................................................. 5 Reflections ............................................................................................. 8 2. Epigenetic Mechanisms of Gene Regulation: Relationships between DNA Methylation, Histone Modification, and Chromatin Structure ..................................................................... 13 Keith D. Robertson The Mammalian DNA Methyltransferases (DNMTs) ......................... 14 Interaction between DNMTs and Other Proteins ............................... 16 DNA Methylation and DNA Replication ............................................ 20 Links between DNA Methylation and Histone Modification .............. 20 DNA Methylation and Histone Methylation ...................................... 21 DNMTs As Transcriptional Corepressors ........................................... 22 DNA Methylation and Chromatin Remodeling .................................. 24 3. DNA Hypo- vs. Hypermethylation in Cancer: Tumor Specificity, Tumor Progression, and Therapeutic Implications .............................. 31 Melanie Ehrlich and GuanchaoJiang Are There Tumor-Specific DNA Hypomethylation Profiles Like the Tumor-Specific DNA Hypermethylation Profiles? .................... 32 Is There a Relationship between Cancer-Associated DNA, Hypomethylation and DNA Hypermethylation? ............................. 34 Is DNA Hypomethylation, Like DNA Hypermethylation, Sometimes Associated with Tumor Progression? .............................. 35 Might There Be Deleterious Consequences of Introducing DNA Hypomethylation in the Genome As a Cancer Therapy? ................. 37 4. DNA Methylation in Urological Cancers ............................................. 42 Wolfgang A. Schulz and Hans-Helge Seifert An Overview of Urological Cancers ..................................................... 42 A Description of DNA Methylation Changes in Urological Malignancies .............................................................. 44 A Global View of DNA Methylation Alterations in Urological Cancers ...................................................................... 47 Causes of Altered DNA Methylation in Urological Cancers ................ 48 Consequences of Altered DNA Methylation in Urological Cancers ....... 50 DNA Methylation in Diagnosis and Therapy of Urological Cancers ...... 51 Szyf MIU Front Matter 9/15/04, 2:29 PM 5 5. DNA Methylation in Colorectal Cancer ............................................... 59 Jeremy R. Jass, Vicki L.J. Whitehall, Joanne Young and Barbara A. Leggett Relevance of Familial Models of Colorectal Cancer to Sporadic Neoplasia ...................................................................... 60 DNA Microsatellite Instability ............................................................ 60 Mechanisms Underlying Microsatellite Instability in Colorectal Cancer .........................