Computational Methods for Protein Folding, Volume 120 (eBook, PDF)

Redaktion: Friesner, Richard A.

• Format: PDF

Produktbeschreibung

Since the first attempts to model proteins on a computer began almost thirty years ago, our understanding of protein structure and dynamics has dramatically increased. Spectroscopic measurement techniques continue to improve in resolution and sensitivity, allowing a wealth of information to be obtained with regard to the kinetics of protein folding and unfolding, and complementing the detailed structural picture of the folded state. Concurrently, algorithms, software, and computational hardware have progressed to the point where both structural and kinetic problems may be studied with a fair degree of realism. Despite these advances, many major challenges remain in understanding protein folding at both the conceptual and practical levels. Computational Methods for Protein Folding seeks to illuminate recent advances in computational modeling of protein folding in a way that will be useful to physicists, chemists, and chemical physicists. Covering a broad spectrum of computational methods and practices culled from a variety of research fields, the editors present a full range of models that, together, provide a thorough and current description of all aspects of protein folding. A valuable resource for both students and professionals in the field, the book will be of value both as a cutting-edge overview of existing information and as a catalyst for inspiring new studies. Computational Methods for Protein Folding is the 120th volume in the acclaimed series Advances in Chemical Physics, a compilation of scholarly works dedicated to the dissemination of contemporary advances in chemical physics, edited by Nobel Prize-winner Ilya Prigogine.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 544
• Erscheinungstermin: 24. März 2004
• Englisch
• ISBN-13: 9780471465232
• Artikelnr.: 37302009

Autorenporträt

Richard Friesner is Professor of Chemistry at Columbia University.

Inhaltsangabe

Statistical Analysis of Protein Folding Kinetics (A. Dinner, et al).
Insights into Specific Problems in Protein Folding Using Simple Concepts
(D. Thirumalai, et al.). Protein Recognition by Sequence-to-Structure
Fitness: Bridging Efficiency and Capacity of Threading Models (J. Meller
and R. Elber). A Unified Approach to the Prediction of Protein Structure
and Function (J. Skolnick and A. Kolinski). Knowledge-Based Prediction of
Protein Tertiary Structure (P. L'Heureux, et al.). Ab Initio Protein
Structure Prediction Using a Size-Dependent Tertiary Folding Potential (V.
Eyrich, et al.). Deterministic Global Optimization and Ab Initio Approaches
for the Structure Prediction of Polypeptides, Dynamics of Protein Folding,
and Protein-Protein Interactions (J. Klepeis, et al.). Detecting Native
Protein Folds Among Large Decoy Sites with the OPLS All-Atom Potential and
the Surface Generalized Born Solvent Model (A. Wallqvist, et al.). Author
Index. Subject Index.

Rezensionen

"...should prove to be an excellent addition to the collection of reference texts held by scientists..." ( Journal of the American Chemical Society , Vol. 124, No. 41, 2002)