- Classics in Total Synthesis71,99 €
- Classics in Total Synthesis II67,99 €
- Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives98,99 €
- Total Chemical Synthesis of Proteins130,99 €
- Amino Acids, Peptides and Proteins in Organic Chemistry 05138,99 €
- Amino Acids, Peptides and Proteins in Organic Chemistry141,99 €
- Chemical Synthesis of Hormones, Pheromones and Other Bioregulators161,99 €
- Verlag: Wiley-VCH / Wiley-VCH GmbH
- Artikelnr. des Verlages: 1132957 000
- Erscheinungstermin: 9. Februar 2011
- Abmessung: 256mm x 194mm x 33mm
- Gewicht: 1667g
- ISBN-13: 9783527329571
- ISBN-10: 3527329579
- Artikelnr.: 30685972
1 Introduction Nicolaou's Retrosynthetic Analysis and Strategy Nicolaou's Total Synthesis Evans' Retrosynthetic Analysis and Strategy Evans' Total Synthesis Conclusion THIOSTREPTON Introduction Retrosynthetic Analysis and Strategy Total Synthesis Conclusion PENTACYCLOANAMMOXIC ACID METHYL ESTER Introduction First
Generation Retrosynthetic Analysis and Strategy First
Generation Total Synthesis Second
Generation Retrosynthetic Analysis and Strategy Second
Generation Total Synthesis Conclusion LITTORALISONE, OSELTAMIVIR (TAMIFLU®), AND HIRSUTELLONE B Introduction Introduction to Littoralisone Total Synthesis of Littoralisone Introduction to Oseltamivir (Tamiflu®) Total Synthesis of Oseltamivir (Tamiflu®) Introduction to Hirsutellone B Total Synthesis of Hirsutellone B Conclusion RUBICORDIFOLIN AND RUBIONCOLIN B Introduction Retrosynthetic Analysis of Rubicordifolin Total Synthesis of Rubicordifolin Retrosyntheticd Analysis of Rubioncolin B Total Synthesis of Rubioncolin B Conclusion CYANTHIWIGINS U AND F Introduction Phillips' Retrosynthetic Analysis and Strategy Phillips' Total Synthesis Stolz' Retrosynthetic Analysis and Strategy Stoltz' Total Synthesis Conclusion STEPHACIDIN B Introduction Myers' Retrosynthetic Analysis and Strategy Meyers' Total Synthesis Baran's Retrosynthetic Analysis and Strategy Baran's Total Synthesis Williams' Retrosynthetic Analysis and Strategy Williams' Total Synthesis Conclusion ABYSSOMICIN C AND ATROP
ABYSSOMICIN C Introduction Sorensen's Retrosynthetic Analysis and Strategy Sorensen's Total Synthesis of Abyssomicin C Nicolaou's Retrosynthetic Analysis and Strategy Nicolaou's Total Synthesis of Abyssomicin C and atrop
Abyssomicin C Conclusion TETRACYCLINE Introduction Retrosynthetic Analysis and Strategy Total Synthesis Conclusion BISANTHRAQUINONE NATURAL PRODUCTS Introduction Retrosynthetic Analysis and Strategy Toward 2,2'
Cytoskyrin A, Rugulosin, and Rugulin Total Synthesis of 2,2'
Cytoskyrin A, Rugulosin, and Rugulin Retrosynthetic Analysis and Strategy Toward Antibiotic BE
43472B Total Synthesis of Antibiotic BE
43472B Conclusion GARSUBELLIN A Introduction Sibasaki and Kanai's Retrosynthetic Analysis and Strategy Shibasaki and Kanai's Total Synthesis Danishefsky's Retrosynthetic Analysis and Strategy Danishefsky's Total Synthesis Conclusion WELWITINDOLINONE A Introduction Baran's Retrosynthetic Analysis and Strategy Barans' Total Synthesis Wood's Retrosynthetic Analysis and Strategy Wood's Total Synthesis Conclusion IEJIMALIDE B Introduction Retrosynthetic Analysis and Strategy Total Synthesis Conclusion KEDARCIDIN CHROMOPHORE AND MADUROPEPTIN CHROMOPHORE Introduction Retrosynthetic Analysis and Strategy for Kedarcidin Chromophore Total Synthesis of Kedarcidin Chromophore Retrosynthetic Analysis and Strategy for Maduropeptin Chromophore Total Synthesis of Maduropeptin Chromophore Conclusion BIYOUYANAGIN A Introduction Retrosynthetic Analysis and Strategy Total Synthesis Conclusion AZADIRACHTIN Introduction Retrosynthetic Analysis and Strategy Synthesis Conclusion RESVERATROL
DERIVED NATURAL PRODUCTS Introduction Snyder's Retrosynthetic Analysis and Strategy for a Collection of Resveratrol
Derived Natural Products Snyder's Total Synthesis of a Collection of Resveratrol
Derived Natural Products Nicolaou and Chen's Retrosynthetic Analysis and Strategy for Hopeahainol A and Hopeanol Nicolaou and Chen's Total Synthesis of Hopeahainol A and Hopeanol Conclusion CHLOROSULFOLIPID CYTOTOXIN Introduction Retrosynthetic Analysis and Strategy Total Synthesis Conclusion SPOROLIDE B Introduction Retrosynthetic Analysis and Strategy Total Synthesis Conclusion 11,11'
DIDEOXYVERTICILLIN A AND CHAETOCIN Introduction Retrosynthetic Analysis and Strategy for 11,11'
Dideoxyverticillin A Total Synthesis of 11,11'
Dideoxyverticillin A Retrosynthetic Analysis and Strategy for Chaetocin Total Synthesis of Chaetocin Conclusion VANNUSAL B Introduction Retrosynthetic Analysis and Strategy Total Synthesis Conclusion HAPLOPHYTINE Introduction Fukuyama and Tokuyama's Retrosynthetic Analysis and Strategy Fukuyama and Tokuyama's Total Synthesis Nicolaou and Chen's Retrosynthetic Analysis and Strategy Nicolaou and Chen's Total Synthesis Conclusion PALAU'AMINE Introduction Retrosynthetic Analysis and Strategy Total Synthesis Conclusion
The concept of the preceding volumes has been closely retained. In 26 chapters, including an introductory chapter, syntheses of more than 40 natural products or natural product core structures are discussed in detail. The syntheses, together with historical excursions, have been taken from literature of the years 2003 to 2010. Each chapter begins with background information about the discovery, structure elucidation, and biological significance of the target molecule(s). To aid the reader_s orientation, key concepts of the total synthesis described are provided at the beginning of each chapter. After describing retrosyntheses that have been achieved, and any preliminary synthetic work, the chapter gives a very detailed description of the synthesis of the target structure, including almost all the individual steps. All literature references are clearly identified by chapter endnotes, thus allowing rapid access to the primary sources. The chapter ends with a short summary and a well-chosen, detailed, and extensive list of references. This alone is one of the great strengths of the book, and provides every synthetic chemist with an excellent pool for the solution of his or her own synthetic problems. Also particularly valuable for the reader are the short reviews on specific topics, which have the scope and style of review articles. Thus, one finds surveys on current topics of interest such as organocatalysis (Chapter 7: littoralisone, oseltamivir, hirsutellone B) and C_H activation (Chapter 2: tetrodotoxin) next to overviews of more classical themes such as Schenk ene reactions with singlet oxygen (Chapter 12: tetracycline), photochemically induced [2+2] cycloadditions (Chapter 18: biyouyanagin A), [2+2+2] cycloadditions, Diels-Alder reactions with o-quinones (Chapter 22: sporolid B), and Kagan-Molander SmI2 couplings (Chapter 24: vannusal B). The review of asymmetric halogenation reactions (Chapter 21: chlorosulfolipid cytotoxin) is particularly well-written, as it clearly demonstrates, to the young scientist as well as to the post- or pre-graduate student, that there are still enough chemical transformations that have not yet been sufficiently studied, and therefore leave room for personal creativity and ambition.
Novelties of this third volume compared to the previous ones are mainly concerned with the detailed contents. The depth of mechanistic discussions has been greatly increased. The introductions to the chapters often feature insights into the biosynthesis of the natural product concerned (e.g., Chapter 10: stephacidin). Some small sections describe problems associated with structure elucidation, which then led to revision of the supposed structure in the context of the total synthesis (e.g., in Chapter 4: azaspiracid-1). The very instructive concept of discussing and comparing several different syntheses of a target structure in a parallel fashion, which was introduced in the second volume of this series, has now been further developed in a clever way. Sometimes it would also have been useful for the synthetic chemist reader to be given an explanation of why a specific unusual reagent was chosen at a certain stage during the planning or carrying out of a synthesis, and why an apparently more convenient and conventional procedure was avoided. Such explanations, and possibly also descriptions of unsuccessful attempted routes, could give the reader an even more detailed insight into problems of reactivity or selectivity of a specific reagent or substrate.
The layout of this book has only been slightly changed compared with previous volumes. One innovation is the introduction of a colored title page at the beginning of each chapter, presenting an attractive graphical illustration of the target structure, together with its natural source and a picture of the leader of the group that worked on the total synthesis. However, the opportunity to similarly illustrate other parts of the chapter has not been taken; especially in the introduction, figures or graphics in color might have improved the accessibility of the contents. The question of whether it would be an advantage to also introduce color into the synthetic schemes depends on the reader_s personal taste as well as the costs of the book. On the other hand, the great success of this series does support a continuation of the style in its present form.
As the selection of synthetic target molecules for this book is exclusively taken from the more recent literature, in contrast to the first volume of the series, it remains to be seen whether the syntheses described will eventually become true classics. This book will certainly contribute its share to ensuring that these syntheses will be used as outstanding models for teaching and research purposes, even 20 or more years from now. One could also consider an even broader selection of target molecules and structures, which might be less close to the main author_s field of work and experience (at least 10 out of 26 chapters deal with the author_s syntheses). Indisputably, K. C. Nicolaou has made outstanding contributions in his research field. But who would not, for this very reason, like to see discussions of other scientists_ syntheses by the master himself?
A particularly extensive account is given in Chapter 3, which describes an impressive 60 g total synthesis of discodermolide by Novartis. This clearly demonstrates the increasing scientific, but also industrial, importance of complex syntheses of natural products. The present volume - and hopefully future books of this series - offer an exciting and outstanding overview of the subject of natural products total syntheses in its complexity and variety. Classics in Total Synthesis III will surely itself become a classic in the literature on the state of the art of contemporary organic synthetic chemistry.
Dirk Menche, Sebastian Essig
Ruprecht-Karls-Universität Heidelberg (Germany)
Angew. Chem. Int. Ed. 2011, 50, 5995 - 5996