Bioinformatics for Glycobiology and Glycomics (eBook, PDF)

An Introduction
Redaktion: Lieth, Claus-Wilhelm von der; Frank, Martin; Luetteke, Thomas

• Format: PDF

Produktbeschreibung

This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein-carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein-carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: * Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. * Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. * Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. * Assumes only a basic knowledge of biology and bioinformatics.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 494
• Erscheinungstermin: 18. September 2009
• Englisch
• ISBN-13: 9780470029602
• Artikelnr.: 37289879

Autorenporträt

Dr. Claus-Wilhelm von der Lieth, died 2007. Thomas Lütteke, Justus-Liebig University Giessen, Germany; Fakulty of Veterinary Medicine, Institute of Biochemistry und Endocrinology. Dr. Martin Frank, German Cancer Research Center, Heidelberg, Germany; Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands.

Inhaltsangabe

List of Contributors. Preface (Claus-Wilhelm von der Lieth). Section 1:
Introduction. 1. Glycobiology, Glycomics and (Bio)Informatics
(Claus-Wilhelm von der Lieth). Section 2: Carbohydrate Structures. 2.
Introduction to Carbohydrate Structure and Diversity (Stephan Herget, René
Ranzinger, Robin Thomson, Martin Frank and Claus-Wilhelm von der Lieth). 3.
Digital Representations of Oligo- and Polysaccharides (Stephan Herget and
Claus-Wilhelm von der Lieth). 4. Evolutionary Considerations in Studying
the Sialome: Sialic Acids and the Host-Pathogen Interface (Amanda L. Lewis
and Ajit Varki). Section 3: Carbohydrate-active Enzymes and Glycosylation.
5. Carbohydrate-active Enzymes Database: Principles and Classification of
Glycosyltransferases (Pedro M. Coutinho, Corinne Rancurel, Mark Stam,
Thomas Bernard, Francisco M. Couto, Etienne G. J. Danchin and Bernard
Henrissat). 6. Other Databases Providing Glycoenzyme Data (Thomas L¿utteke
and Claus-Wilhelm von der Lieth). 7. Bioinformatics Analysis of Glycan
Structures from a Genomic Perspective (Kiyoko F. Aoki-Kinoshita and Minoru
Kanehisa). 8. Glycosylation of Proteins (Claus-Wilhelm von der Lieth and
Thomas Lüteke). 9. Prediction of Glycosylation Sites in Proteins (Karin
Julenius, Morten B. Johansen, Yu Zhang, Søren Brunak and Ramneek Gupta).
Section 4: Experimental Methods - Bioinformatic Requirements. 10.
Experimental Methods for the Analysis of Glycans and Their Bioinformatics
Requirements (Claus-Wilhelm von der Lieth). 11. Analysis of N- and
O-Glycans of Glycoproteins by HPLC Technology (Anthony H. Merry and
Sviatlana A. Astrautsova). 12. Glycomic Mass Spectrometric Analysis and
Data Interpretation Tools (Niclas G. Karlsson and Nicolle H. Packer). 13.
Software Tools for Semi-automatic Interpretation of Mass Spectra of Glycans
(Kai Maass and Alessio Ceroni). 14. Informatics Concepts to Decode
Structure-Function Relationships of Glycosaminoglycans (Rahul Raman, S.
Raguram and Ram Sasisekharan). 15. NMR Databases and Tools for Automatic
Interpretation of Spectra of Carbohydrates (Claus-Wilhelm von der Lieth).
16. Automatic Spectrum Interpretation Based on Increment Rules: CASPER
(Roland Stenutz). 17. Interpretation of 13C NMR Spectra by Artificial
Neural Network Techniques (NeuroCarb) (Andreas Stoeckli, Matthias Studer,
Brian Cutting and Beat Ernst). Section 5: 3D Structures of Complex
Carbohydrates. 18. Conformational Analysis of Carbohydrates - A Historical
Overview (Martin Frank). 19. Predicting Carbohydrate 3D Structures Using
Theoretical Methods (Martin Frank). 20. Synergy of Computational and
Experimental Methods in Carbohydrate 3D Structure Determination and
Validation (Thomas Lütteke and Martin Frank). Section 6:
Protein-Carbohydrate Interaction. 21. Structural Features of Lectins and
Their Binding Sites (Remy Loris). 22. Statistical Analysis of
Protein-Carbohydrate Complexes Contained in the PDB (Thomas Lütteke and
Claus-Wilhelm von der Lieth). Section 7: Appendices. Appendix 1: List of
Available Websites. Appendix 2: Glossary. Index.