Advances in Enzymology and Related Areas of Molecular Biology, Volume 77 (eBook, PDF)

• Format: PDF

Produktbeschreibung

This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 432
• Erscheinungstermin: 10. Februar 2011
• Englisch
• ISBN-13: 9780470920527
• Artikelnr.: 37300583

Autorenporträt

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is also the Deputy Director for Technology for the Advanced Research Projects Agency-Energy (ARPA-E) of the Department of Energy and directs the ARPA-E's Electrofuels program.

Inhaltsangabe

Contributors. Preface. Structure and Mechanism of RND-Type Multidrug Efflux Pumps (Hiroshi Nikaido). Efflux Pumps of Gram-Negative Bacteria: Genetic Responses to Stress and the Modulation of Their Activity by pH, Inhibitors, and Phenothiazines (Leonard Amaral, Seamus Fanning, and Jean-Marie Pagès). Efflux Pumps of the Resistance-Nodulation-Division Family: A Perspective of Their Structure, Function, and Regulation in Gram-Negative Bacteria (Mathew D. Routh, Yaramah Zalucki, Chih-Chia Su, Feng Long, Qijing Zhang, William M. Shafer, and Edward W. Yu). The MFS Efflux Proteins of Gram-Positive and Gram-Negative Bacteria (Massoud Saidijam, Kim E. Bettaney, Dong Leng, Pikyee Ma, Zhiqiang Xu, Jeffrey N. Keen, Nicholas G. Rutherford, Alison Ward, Peter J. F. Henderson, Gerda Szakonyi, Qinghu Ren, Ian T. Paulsen, Ingerid Nes, Jasmin K. Kroeger, and Anne-Brit Kolsto). Efflux Pumps as an Important Mechanism for Quinolone Resistance (Jordi Vila, Anna Fabrega, Ignasi Roca, Alvaro Hernandez, and Jose Luis Martinez). Xenobiotic Efflux in Bacteria and Fungi: A Genomics Update (Ravi D. Barabote, Jose Thekkiniath, Richard E. Strauss, Govindsamy Vediyappan, Joe A. Fralick, and Michael J. San Francisco). A Survey of Oxidative Paracatalytic Reactions Catalyzed by Enzymes That Generate Carbanionic Intermediates: Implications for ROS Production, Cancer Etiology, and Neurodegenerative Diseases (Victoria I. Bunik, John V. Schloss, John T. Pinto, Natalia Dudareva, and Arthur J. L. Cooper). Author Index. Subject Index.

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Contributors. Preface. Structure and Mechanism of RND-Type Multidrug Efflux Pumps (Hiroshi Nikaido). Efflux Pumps of Gram-Negative Bacteria: Genetic Responses to Stress and the Modulation of Their Activity by pH
Inhibitors
and Phenothiazines (Leonard Amaral
Seamus Fanning
and Jean-Marie Pagès). Efflux Pumps of the Resistance-Nodulation-Division Family: A Perspective of Their Structure
Function
and Regulation in Gram-Negative Bacteria (Mathew D. Routh
Yaramah Zalucki
Chih-Chia Su
Feng Long
Qijing Zhang
William M. Shafer
and Edward W. Yu). The MFS Efflux Proteins of Gram-Positive and Gram-Negative Bacteria (Massoud Saidijam
Kim E. Bettaney
Dong Leng
Pikyee Ma
Zhiqiang Xu
Jeffrey N. Keen
Nicholas G. Rutherford
Alison Ward
Peter J. F. Henderson
Gerda Szakonyi
Qinghu Ren
Ian T. Paulsen
Ingerid Nes
Jasmin K. Kroeger
and Anne-Brit Kolsto). Efflux Pumps as an Important Mechanism for Quinolone Resistance (Jordi Vila
Anna Fabrega
Ignasi Roca
Alvaro Hernandez
and Jose Luis Martinez). Xenobiotic Efflux in Bacteria and Fungi: A Genomics Update (Ravi D. Barabote
Jose Thekkiniath
Richard E. Strauss
Govindsamy Vediyappan
Joe A. Fralick
and Michael J. San Francisco). A Survey of Oxidative Paracatalytic Reactions Catalyzed by Enzymes That Generate Carbanionic Intermediates: Implications for ROS Production
Cancer Etiology
and Neurodegenerative Diseases (Victoria I. Bunik
John V. Schloss
John T. Pinto
Natalia Dudareva
and Arthur J. L. Cooper). Author Index. Subject Index.