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This book provides basic principles of multivalent interactions found in biological systems as well as an up-to-date and thorough coverage in design concepts, syntheses, and biological activities of multivalent molecules. _ Contains practical examples of synthetic multivalent molecules in chemistry, biology, and medicine _ Can be used as both a textbook for students and a reference book for libraries and professionals _ Includes detailed case studies _ Fills a void in current literature through its devotion solely to multivalent molecules
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This book provides basic principles of multivalent interactions found in biological systems as well as an up-to-date and thorough coverage in design concepts, syntheses, and biological activities of multivalent molecules.
_ Contains practical examples of synthetic multivalent molecules in chemistry, biology, and medicine
_ Can be used as both a textbook for students and a reference book for libraries and professionals
_ Includes detailed case studies
_ Fills a void in current literature through its devotion solely to multivalent molecules
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
_ Contains practical examples of synthetic multivalent molecules in chemistry, biology, and medicine
_ Can be used as both a textbook for students and a reference book for libraries and professionals
_ Includes detailed case studies
_ Fills a void in current literature through its devotion solely to multivalent molecules
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 448
- Erscheinungstermin: 1. September 2004
- Englisch
- Abmessung: 240mm x 160mm x 28mm
- Gewicht: 740g
- ISBN-13: 9780471563471
- ISBN-10: 0471563471
- Artikelnr.: 12986796
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 448
- Erscheinungstermin: 1. September 2004
- Englisch
- Abmessung: 240mm x 160mm x 28mm
- Gewicht: 740g
- ISBN-13: 9780471563471
- ISBN-10: 0471563471
- Artikelnr.: 12986796
SEOK-KI CHOI works for Theravance, Inc., where he gained firsthand insight into the application of multivalent drug design and development. Prior to his work at Theravance, he served on the faculty in the Department of Chemistry and Chemical Biology at Harvard University, establishing his credentials in the field. He is a member of the American Chemical Society and has authored several papers and articles in the biochemistry field.
Preface. Notes for Organization and Classification. Abbreviations. 1
Introduction. 1.1 Nomenclature and Definitions. 1.2 Mechanistic Aspects of
Multivalent Interaction. 1.3 Biological Roles of Multivalent Ligands. 2
Multivalent Molecules Applied to Viral Targets. 2.1 Influenza Virus. 2.2
Human Immunodeficiency Virus. 2.3 Rotavirus. 2.4 Polyoma Virus. 2.5 Picorna
Virus. 2.6 Respiratory Syncytial Virus. 2.7 Dengue Virus. 2.8 Nucleic Acids
of Viruses. 2.9 Synthetic Multivalent Vaccines. 3 Multivalent Molecules
Applied to Bacterial Targets. 3.1 Targets in Bacterial Cell Membranes. 3.2
Bacterial Toxins. 3.3 Bacterial Enzymes. 3.4 Bacterial Nucleic Acids. 3.5
Multivalent Molecules as Synthetic Vaccines. 3.6 Fungal Cells. 4
Multivalent Molecules Applied to Cellular Targets. 4.1
Carbohydrate-Recognition Receptors on Cell Surfaces. 4.2 Peptide and
Hormone Recognition Receptors on Cell Surfaces. 4.3 Ligand-Mediated
Receptor Dimerization. 4.4 Enzymes. 4.5 G-Protein-Coupled Receptors. 4.6
Ion Channels. 4.7 Nucleic Acids. 4.8 Antibodies. 4.9 Cell Surface
Engineering. 5 Chemical Synthesis of Multivalent Molecules. 5.1 Selected
Synthetic Methods for Multimerization. 5.2 Combinatorial Chemistry.
Appendix. Table 1. Divalent Ligands Linked to Enzymes in Human
Immunodeficiency Virus (HIV). Table 2. Multivalent Ligands Linked to gp120
Surface Receptors in Human Immunodeficiency Virus. Table 3. Multivalent
Ligands Linked to Surface Receptors on Viruses. Table 4. Multivalent
Receptors Targeting Multivalent Ligands in Bacterial Cell Walls. Table 5.
Multivalent Ligands Targeting Bacterial Receptors in Membrane Surfaces.
Table 6. Multivalent Ligands Linked to Bacterial Toxins. Table 7.
Multivalent Molecules Targeting Bacterial Enzymes. Table 8. Multivalent
Ligands Targeting Carbohydrate-Recognition Receptors on Cellular Surfaces.
Table 9. Multivalent Ligands Targeting Noncarbohydrate-Recognition
Receptors on Cellular Surfaces. Table 10. Multivalent Ligands Linked to
Selectins on Cell Surfaces. Table 11. Multivalent Ligands Linked to
Lectins. Table 12. Multivalent Ligands Linked to Cellular Enzymes. Table
13. Multivalent Ligands Linked to G-Protein-Coupled Receptors (GPCRs).
Table 14. Multivalent Ion Channel-Binding Molecules. Table 15. Homo- and
Heterodivalent Chemical Inducers of Dimerization (CIDs). Table 16.
Multivalent Ligands Linked to Nucleic Acids. Table 17. Synthetic
Multivalent Antigens. Table 18. Multivalent Ligands Displayed on
Self-Assembled Monolayer (SAM) Made of Alkanethiolate on Gold. Table 19.
(Bio)chemical Modification of Cell Surface Antigens. Table 20. Multivalent
Targets. References. Index.
Introduction. 1.1 Nomenclature and Definitions. 1.2 Mechanistic Aspects of
Multivalent Interaction. 1.3 Biological Roles of Multivalent Ligands. 2
Multivalent Molecules Applied to Viral Targets. 2.1 Influenza Virus. 2.2
Human Immunodeficiency Virus. 2.3 Rotavirus. 2.4 Polyoma Virus. 2.5 Picorna
Virus. 2.6 Respiratory Syncytial Virus. 2.7 Dengue Virus. 2.8 Nucleic Acids
of Viruses. 2.9 Synthetic Multivalent Vaccines. 3 Multivalent Molecules
Applied to Bacterial Targets. 3.1 Targets in Bacterial Cell Membranes. 3.2
Bacterial Toxins. 3.3 Bacterial Enzymes. 3.4 Bacterial Nucleic Acids. 3.5
Multivalent Molecules as Synthetic Vaccines. 3.6 Fungal Cells. 4
Multivalent Molecules Applied to Cellular Targets. 4.1
Carbohydrate-Recognition Receptors on Cell Surfaces. 4.2 Peptide and
Hormone Recognition Receptors on Cell Surfaces. 4.3 Ligand-Mediated
Receptor Dimerization. 4.4 Enzymes. 4.5 G-Protein-Coupled Receptors. 4.6
Ion Channels. 4.7 Nucleic Acids. 4.8 Antibodies. 4.9 Cell Surface
Engineering. 5 Chemical Synthesis of Multivalent Molecules. 5.1 Selected
Synthetic Methods for Multimerization. 5.2 Combinatorial Chemistry.
Appendix. Table 1. Divalent Ligands Linked to Enzymes in Human
Immunodeficiency Virus (HIV). Table 2. Multivalent Ligands Linked to gp120
Surface Receptors in Human Immunodeficiency Virus. Table 3. Multivalent
Ligands Linked to Surface Receptors on Viruses. Table 4. Multivalent
Receptors Targeting Multivalent Ligands in Bacterial Cell Walls. Table 5.
Multivalent Ligands Targeting Bacterial Receptors in Membrane Surfaces.
Table 6. Multivalent Ligands Linked to Bacterial Toxins. Table 7.
Multivalent Molecules Targeting Bacterial Enzymes. Table 8. Multivalent
Ligands Targeting Carbohydrate-Recognition Receptors on Cellular Surfaces.
Table 9. Multivalent Ligands Targeting Noncarbohydrate-Recognition
Receptors on Cellular Surfaces. Table 10. Multivalent Ligands Linked to
Selectins on Cell Surfaces. Table 11. Multivalent Ligands Linked to
Lectins. Table 12. Multivalent Ligands Linked to Cellular Enzymes. Table
13. Multivalent Ligands Linked to G-Protein-Coupled Receptors (GPCRs).
Table 14. Multivalent Ion Channel-Binding Molecules. Table 15. Homo- and
Heterodivalent Chemical Inducers of Dimerization (CIDs). Table 16.
Multivalent Ligands Linked to Nucleic Acids. Table 17. Synthetic
Multivalent Antigens. Table 18. Multivalent Ligands Displayed on
Self-Assembled Monolayer (SAM) Made of Alkanethiolate on Gold. Table 19.
(Bio)chemical Modification of Cell Surface Antigens. Table 20. Multivalent
Targets. References. Index.
Preface. Notes for Organization and Classification. Abbreviations. 1
Introduction. 1.1 Nomenclature and Definitions. 1.2 Mechanistic Aspects of
Multivalent Interaction. 1.3 Biological Roles of Multivalent Ligands. 2
Multivalent Molecules Applied to Viral Targets. 2.1 Influenza Virus. 2.2
Human Immunodeficiency Virus. 2.3 Rotavirus. 2.4 Polyoma Virus. 2.5 Picorna
Virus. 2.6 Respiratory Syncytial Virus. 2.7 Dengue Virus. 2.8 Nucleic Acids
of Viruses. 2.9 Synthetic Multivalent Vaccines. 3 Multivalent Molecules
Applied to Bacterial Targets. 3.1 Targets in Bacterial Cell Membranes. 3.2
Bacterial Toxins. 3.3 Bacterial Enzymes. 3.4 Bacterial Nucleic Acids. 3.5
Multivalent Molecules as Synthetic Vaccines. 3.6 Fungal Cells. 4
Multivalent Molecules Applied to Cellular Targets. 4.1
Carbohydrate-Recognition Receptors on Cell Surfaces. 4.2 Peptide and
Hormone Recognition Receptors on Cell Surfaces. 4.3 Ligand-Mediated
Receptor Dimerization. 4.4 Enzymes. 4.5 G-Protein-Coupled Receptors. 4.6
Ion Channels. 4.7 Nucleic Acids. 4.8 Antibodies. 4.9 Cell Surface
Engineering. 5 Chemical Synthesis of Multivalent Molecules. 5.1 Selected
Synthetic Methods for Multimerization. 5.2 Combinatorial Chemistry.
Appendix. Table 1. Divalent Ligands Linked to Enzymes in Human
Immunodeficiency Virus (HIV). Table 2. Multivalent Ligands Linked to gp120
Surface Receptors in Human Immunodeficiency Virus. Table 3. Multivalent
Ligands Linked to Surface Receptors on Viruses. Table 4. Multivalent
Receptors Targeting Multivalent Ligands in Bacterial Cell Walls. Table 5.
Multivalent Ligands Targeting Bacterial Receptors in Membrane Surfaces.
Table 6. Multivalent Ligands Linked to Bacterial Toxins. Table 7.
Multivalent Molecules Targeting Bacterial Enzymes. Table 8. Multivalent
Ligands Targeting Carbohydrate-Recognition Receptors on Cellular Surfaces.
Table 9. Multivalent Ligands Targeting Noncarbohydrate-Recognition
Receptors on Cellular Surfaces. Table 10. Multivalent Ligands Linked to
Selectins on Cell Surfaces. Table 11. Multivalent Ligands Linked to
Lectins. Table 12. Multivalent Ligands Linked to Cellular Enzymes. Table
13. Multivalent Ligands Linked to G-Protein-Coupled Receptors (GPCRs).
Table 14. Multivalent Ion Channel-Binding Molecules. Table 15. Homo- and
Heterodivalent Chemical Inducers of Dimerization (CIDs). Table 16.
Multivalent Ligands Linked to Nucleic Acids. Table 17. Synthetic
Multivalent Antigens. Table 18. Multivalent Ligands Displayed on
Self-Assembled Monolayer (SAM) Made of Alkanethiolate on Gold. Table 19.
(Bio)chemical Modification of Cell Surface Antigens. Table 20. Multivalent
Targets. References. Index.
Introduction. 1.1 Nomenclature and Definitions. 1.2 Mechanistic Aspects of
Multivalent Interaction. 1.3 Biological Roles of Multivalent Ligands. 2
Multivalent Molecules Applied to Viral Targets. 2.1 Influenza Virus. 2.2
Human Immunodeficiency Virus. 2.3 Rotavirus. 2.4 Polyoma Virus. 2.5 Picorna
Virus. 2.6 Respiratory Syncytial Virus. 2.7 Dengue Virus. 2.8 Nucleic Acids
of Viruses. 2.9 Synthetic Multivalent Vaccines. 3 Multivalent Molecules
Applied to Bacterial Targets. 3.1 Targets in Bacterial Cell Membranes. 3.2
Bacterial Toxins. 3.3 Bacterial Enzymes. 3.4 Bacterial Nucleic Acids. 3.5
Multivalent Molecules as Synthetic Vaccines. 3.6 Fungal Cells. 4
Multivalent Molecules Applied to Cellular Targets. 4.1
Carbohydrate-Recognition Receptors on Cell Surfaces. 4.2 Peptide and
Hormone Recognition Receptors on Cell Surfaces. 4.3 Ligand-Mediated
Receptor Dimerization. 4.4 Enzymes. 4.5 G-Protein-Coupled Receptors. 4.6
Ion Channels. 4.7 Nucleic Acids. 4.8 Antibodies. 4.9 Cell Surface
Engineering. 5 Chemical Synthesis of Multivalent Molecules. 5.1 Selected
Synthetic Methods for Multimerization. 5.2 Combinatorial Chemistry.
Appendix. Table 1. Divalent Ligands Linked to Enzymes in Human
Immunodeficiency Virus (HIV). Table 2. Multivalent Ligands Linked to gp120
Surface Receptors in Human Immunodeficiency Virus. Table 3. Multivalent
Ligands Linked to Surface Receptors on Viruses. Table 4. Multivalent
Receptors Targeting Multivalent Ligands in Bacterial Cell Walls. Table 5.
Multivalent Ligands Targeting Bacterial Receptors in Membrane Surfaces.
Table 6. Multivalent Ligands Linked to Bacterial Toxins. Table 7.
Multivalent Molecules Targeting Bacterial Enzymes. Table 8. Multivalent
Ligands Targeting Carbohydrate-Recognition Receptors on Cellular Surfaces.
Table 9. Multivalent Ligands Targeting Noncarbohydrate-Recognition
Receptors on Cellular Surfaces. Table 10. Multivalent Ligands Linked to
Selectins on Cell Surfaces. Table 11. Multivalent Ligands Linked to
Lectins. Table 12. Multivalent Ligands Linked to Cellular Enzymes. Table
13. Multivalent Ligands Linked to G-Protein-Coupled Receptors (GPCRs).
Table 14. Multivalent Ion Channel-Binding Molecules. Table 15. Homo- and
Heterodivalent Chemical Inducers of Dimerization (CIDs). Table 16.
Multivalent Ligands Linked to Nucleic Acids. Table 17. Synthetic
Multivalent Antigens. Table 18. Multivalent Ligands Displayed on
Self-Assembled Monolayer (SAM) Made of Alkanethiolate on Gold. Table 19.
(Bio)chemical Modification of Cell Surface Antigens. Table 20. Multivalent
Targets. References. Index.