The Rho GTPases in Cancer (eBook, PDF)

Redaktion: Golen, Kenneth van

• Format: PDF

Produktbeschreibung

The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.

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Produktdetails

• Verlag: Springer-Verlag GmbH
• Seitenzahl: 206
• Erscheinungstermin: 4. Dezember 2009
• Englisch
• ISBN-13: 9781441911117
• Artikelnr.: 37349282

Inhaltsangabe

Table of Contents Preface i. Introduction v. Aron Jaffe and Alan Hall List of Contributors xix. Section I- An Overview of the Rho GTPases Chapter 1. Overview of Rho GTPase History 1. Ellen V. Stevens and Channing J. Der Chapter 2. Rho GTPases and Cancer 43. Devin T. Rosenthal, John Chadwick Brenner, and Sofia D. Merajver Section II- The Rho Regulatory Proteins in Cancer Chapter 3. RhoGDIs in Cancer 67. Anthony N. Anselmo, Gary M. Bokoch, and Céline DerMardirossian Chapter 4. Signaling through Galpha12/13 and RGS-RhoGEFs 93. Nicole Hajicek, Barry Kreutz and Tozu Kazasa Chapter 5. Vav Proteins In Cancer 126. Daniel D. Billadeau Chapter 6. Rho GTPase-Activating Proteins in Cancer 156. Matthew W. Grogg and Yi Zheng Section III- The Rho GTPase Proteins and Cancer Chapter 7. RhoBTB Proteins in Cancer 182. Caroline McKinnon and Harry Mellor Chapter 8. RhoC GTPase in Cancer Progression and Metastasis 197. Kenneth L. van Golen Chapter 9. RhoB GTPase and Farnesyl Transferase Inhibitors (FTIs) in Cancer 219. Minzhou Huang, Lisa D. Laury-Kleintop and George C. Prendergast Chapter 10. Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview 257. Heather Unger and Kenneth L. van Golen Chapter 11. The Rho-Regulated ROCK Kinases in Cancer 273. Grant R. Wickman, Michael Samuel, Pamela A. Lochhead and Michael F. Olson