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After the completion of the human genome project, Proteomics is regarded as the "next frontier." Not only does Proteomics aim at establishing repertories of all proteins expressed in a cell at a given time and under given physiological or developmental conditions, but more importantly, Proteomics aims at unraveling the complex network of interactions in which proteins are involved in the cell. Techniques have been developed to rapidly create protein-protein interactions maps which in turn can be organized into pathways. Proteins serving as hubs in these networks seem to play crucial biological…mehr

Produktbeschreibung
After the completion of the human genome project, Proteomics is regarded as the "next frontier." Not only does Proteomics aim at establishing repertories of all proteins expressed in a cell at a given time and under given physiological or developmental conditions, but more importantly, Proteomics aims at unraveling the complex network of interactions in which proteins are involved in the cell. Techniques have been developed to rapidly create protein-protein interactions maps which in turn can be organized into pathways. Proteins serving as hubs in these networks seem to play crucial biological roles. Some of these proteins may provide new pharmalogical targets for an industry which is rapidly running out of the more classical means of finding new markets. Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design aims at providing a comprehensive yet entertaining view of this rapidly evolving and exciting field. It starts with an overview of the importance of protein-protein interaction in biology (Chapter I). Next, the book dives into Proteomics issues (Chapter II) and describes successful applications of the Proteomics approach. Chapter III focuses on the very specific roles that protein modules play in determining and regulating protein-protein interactions while chapter IV addresses the chemical and energetic underpinnings of such macromolecular interactions. The data generated by a Proteomics approach is abundant and will only be made sense of using bio-informatics: chapter V is dedicated to giving a voice to some of the leaders in the bio-informatics field. Finally, in chapter VI, examples are provided to illustrate the great potential that protein-protein interfaces have as targets for pharmaceuticals.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 22. Dezember 2006
  • Englisch
  • ISBN-13: 9780387245324
  • Artikelnr.: 37287882
Autorenporträt
Gabriel Waksman, Washington University School of Medicine, St. Louis, Missouri, MO, USA
Inhaltsangabe
Preface.- Introduction.- Yeast Two-Hybrid Protein-Protein Interaction Networks.- The Use of Mass Spectrometry in Studyinng Protein-Protein Interaction Mass Spectrometry.- Molecular Recognition in the Immune System.- Computational Methods for Protein Protein Interactions.- Protein-Protein Docking Methods.- Thermochemistry of Binary and Ternary Protein Interactions Measure by Titration Calorimetry: Complex Formation of CD4, HIV gp120, and Anti-gp120.- Protein-Protein Recognition in Phosphotyrosine-Mediated Intracellular Signaling.- Competitive Binding of Proline-Rich Sequences by SH3, WW, and Other Functionally Related Protein Domains.- The Structure and Molecular Interactions of the Bromodomain.- SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60 Src.- Therapeutic tools Against Brain Damage.- A Thermodynamic Guide to Affinity Optimization of Drug Candidates.- Index.
Rezensionen
"While there are several books on Protemics on the market currently, Protemics and Protein-Protein Interactions is unique in that it focuses on technical issues and on the protein interactome itself. This very important and active research area is brought together by some of the leaders in the field to present a coherent entry point into a field that appeals to many. This will be a valuable and long-lived volume. It will certainly make a timely addition to any library or book collection." (Mark A. Lemmon, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania)