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Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter. TOC:Enzymes in Poly(ADP-Ribose) Metabolism.- PARP-2: Structure-Function Relationship.- Targeting the Poly(ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals.- DNA Damage Signaling through Poly(ADP-Ribose).- Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity.- Functional Interactions of PARP-1 with p53.- Dynamic Interaction between PARP-1, PCNA and…mehr

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Produktbeschreibung
Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter. TOC:Enzymes in Poly(ADP-Ribose) Metabolism.- PARP-2: Structure-Function Relationship.- Targeting the Poly(ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals.- DNA Damage Signaling through Poly(ADP-Ribose).- Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity.- Functional Interactions of PARP-1 with p53.- Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1.- PARP-1 as Novel Coactivator of NF-.B in Inflammatory Disorders.- Parp and Epigenetic Regulation.- PARP and the Release of Apoptosis-Inducing Factor from Mitochondria.- Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in Apoptosis.- NAD-Metabolism and Regulatory Functions.- PARP-1 and the Shape of Cell Death.- Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity.- Poly(ADP-Ribose) Polymeraseand Ischemia-Reperfusion Injury.- Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock.- Role of Poly-ADP-Ribosylation in Cancer Development.- PARP Inhibitors and Cancer Therapy.- Poly(ADP-Ribosyl)ation and Aging.- Index.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 11.01.2008
  • Englisch
  • ISBN-13: 9780387360058
  • Artikelnr.: 37286526
Inhaltsangabe
Enzymes in Poly(ADP-Ribose) Metabolism.- PARP-2: Structure-Function Relationship.- Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals.- DNA Damage Signaling through Poly(ADP-Ribose).- Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity.- Functional Interactions of PARP-1 with p53.- Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1.- PARP-1 as Novel Coactivator of NF-?B in Inflammatory Disorders.- PARP and Epigenetic Regulation.- PARP and the Release of Apoptosis-Inducing Factor from Mitochondria.- Genome Degradation by DNAS1L3 Endonuclease.- NAD: Metabolism and Regulatory Functions.- PARP-1 and the Shape of Cell Death.- Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity.- Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury.- Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock.- Role of Poly-ADP-Ribosylation in Cancer Development.- PARP Inhibitors and Cancer Therapy.- Poly(ADP-Ribosyl)ation and Aging.