N-Acetylaspartate (eBook, PDF)
A Unique Neuronal Molecule in the Central Nervous System
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N-Acetylaspartate (eBook, PDF)
A Unique Neuronal Molecule in the Central Nervous System
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- Verlag: Springer US
- Erscheinungstermin: 21. Oktober 2006
- Englisch
- ISBN-13: 9780387301723
- Artikelnr.: 37285296
- Verlag: Springer US
- Erscheinungstermin: 21. Oktober 2006
- Englisch
- ISBN-13: 9780387301723
- Artikelnr.: 37285296
John Moffett, Uniformed Services of the Health Sciences, Bethesda, MD, USA / Suzannah Tieman, University at Albany, NY, USA / Daniel R. Weinberger, National Institute of Mental Health, Bethesday, MD, USA / Joseph T. Coyle, McLean Hospital, Belmont, MA, USA / Aryan M.A. Namboodiri, Uniformed Services of the Health Sciences, Bethesda, MD, USA
A Brief Overview of N-Acetylaspartate and N-Acetylaspartylglutamate.- Expression of N-Acetylaspartate and N-Acetylaspartylglutamate in the Nervous System.- N-Acetylaspartate Metabolism in Neural Cells.- Naa Synthesis and Functional Roles.- Identity of the High-Affinity Sodium/Carboxylate Cotransporter NaC3 as the N-Acetyl-L-Aspartate Transporter.- Canavan Disease: Studies on the Knockout Mouse.- Functions Of N-Acetylaspartate and N-Acetylaspartylglutamate in Brain.- Control of Brain Volume during Hypoosmolality and Hyperosmolality.- Physiological Role of N-Acetylaspartate.- Defective Myelin Lipid Synthesis as a Pathogenic Mechanism of Canavan Disease.- Mutation Analysis of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease.- Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development?.- Quantitation of NAA in the Brain by Magnetic Resonance Spectroscopy.- N-Acetyl-L-Aspartate in Multiple Sclerosis.- NAA and Higher Cognitive Function in Humans.- In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia.- N-Acetylaspartate as a Marker of Neuronal Injury in Neurodegenerative Disease.- Regulation of NAA-Synthesis in the Human Brain in Vivo: Canavan's Disease, Alzheimer's Disease and Schizophrenia.- Magnetic Resonance Spectroscopy for Monitoring Neuronal Integrity in Amyotrophic Lateral Sclerosis.- Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient.- Cellular Localization of NAAG.- Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber.- NAAG as a Neurotransmitter.- Glutamate Carboxypeptidase II (NAALADase) Inhibition as a Novel Therapeutic Strategy.- N-Acetylaspartylglutamate (NAAG) in Spinal Cord Injury and Disease.-N-Acetylaspartylglutamate (NAAG) in Pelizaeusmerzbacher Disease.- Concluding Remarks.
A Brief Overview of N-Acetylaspartate and N-Acetylaspartylglutamate.- Expression of N-Acetylaspartate and N-Acetylaspartylglutamate in the Nervous System.- N-Acetylaspartate Metabolism in Neural Cells.- Naa Synthesis and Functional Roles.- Identity of the High-Affinity Sodium/Carboxylate Cotransporter NaC3 as the N-Acetyl-L-Aspartate Transporter.- Canavan Disease: Studies on the Knockout Mouse.- Functions Of N-Acetylaspartate and N-Acetylaspartylglutamate in Brain.- Control of Brain Volume during Hypoosmolality and Hyperosmolality.- Physiological Role of N-Acetylaspartate.- Defective Myelin Lipid Synthesis as a Pathogenic Mechanism of Canavan Disease.- Mutation Analysis of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease.- Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development?.- Quantitation of NAA in the Brain by Magnetic Resonance Spectroscopy.- N-Acetyl-L-Aspartate in Multiple Sclerosis.- NAA and Higher Cognitive Function in Humans.- In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia.- N-Acetylaspartate as a Marker of Neuronal Injury in Neurodegenerative Disease.- Regulation of NAA-Synthesis in the Human Brain in Vivo: Canavan's Disease, Alzheimer's Disease and Schizophrenia.- Magnetic Resonance Spectroscopy for Monitoring Neuronal Integrity in Amyotrophic Lateral Sclerosis.- Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient.- Cellular Localization of NAAG.- Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber.- NAAG as a Neurotransmitter.- Glutamate Carboxypeptidase II (NAALADase) Inhibition as a Novel Therapeutic Strategy.- N-Acetylaspartylglutamate (NAAG) in Spinal Cord Injury and Disease.-N-Acetylaspartylglutamate (NAAG) in Pelizaeusmerzbacher Disease.- Concluding Remarks.