Ion Channels and Their Inhibitors
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Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with targets based on ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover…mehr

Produktbeschreibung
Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with targets based on ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium Ion, potassium Ion, chloride Ion, calcium Ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, and neurobiology, and medicinal chemistry.
  • Produktdetails
  • Verlag: Springer, Berlin
  • Artikelnr. des Verlages: 80020574
  • Erscheinungstermin: Juli 2011
  • Englisch
  • Abmessung: 250mm x 163mm x 25mm
  • Gewicht: 690g
  • ISBN-13: 9783642199219
  • ISBN-10: 3642199216
  • Artikelnr.: 33073038
Inhaltsangabe
From the contents.:
Structural and Functional Discrimination of Membrane.- Proteins.- Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.- Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers.- Advances in Design and Development of Sodium Channel Blockers.- Potassium Channel Blockers as Anti-arrhythmic Agents.- hERG Potassium Channels in Drug Discovery and Development.- Prediction of hERG Channel Inhibition Using in silico Techniques.- Advances in Structure-Activity Relationship Studies on Potassium Channel Modulators.-
Calcium Ion Channels and Their Blockers.- Therapeutic Potential of N-type Voltage Gated Ca2+ Channel.- Chloride Ion Channels: Structure, Functions, and Blockers.