Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a `must¿ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the `optimal¿ way in which to investigate these phenomena. TOC:Preface.- The Developmental Origins of Health And Disease: The Breadth and Importance of The Concept.- Developmental Origins of Cardiovascular Disease, Type 2 Diabetes and Obesity in Humans.- Studies of Twins: What Can They Tell us About The Developmental Origins of Adult Health and Disease?.- Prenatal Programming of Human Motor Function.- Adaptive Responses of Early Embryos to Their Microenvironment and Consequences for Post-Implantation Development.- Modification of Epigenetic State Through Dietary Manipulation in the Developing Mammalian Embryo.- Critical Experiments to Determine If Early Nutritional Influences on Epigenetic Mechanisms Cause Metabolic Imprinting in Humans .- Manipulation of The Maternal Diet In Rat Pregnancy: Different Approaches to The Demonstration of The Programming Principle.- Programming Hypertension¿Animal Models: Causes and Mechanisms.- Kidney Development and Fetal Programming.- Programming of Obesity¿Experimental Evidence.- Perinatal Programming of Adult Metabolic Homeostasis: Lessons From Experimental Studies.- Programming Effects of Excess Glucocorticoid Exposure In Late Gestation.- Programming Effects of Moderate And Binge Alcohol Consumption.- Vitamin D In Pregnancy and Offspring Health.- The Fetal Origins of Adult Mental Illness.- Hypoxia, Fetal Growth and Developmental Origins of Health and Disease.- Index.
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