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Corynebacterium diphtheriae is the classical etiological agent of diphtheria and the type strain of the genus Corynebacterium. While diphtheria of the respiratory tract became rare with the introduction of vaccination programs in industrialized countries, even today several thousand cases per year are reported to the World Health Organization. This shows that diphtheria is not completely eradicated and that reservoirs exist. The book summarizes the latest advances made in understanding C. diphtheriae and the closely related species Corynebacterium ulcerans and Corynebacterium…mehr

Produktbeschreibung
Corynebacterium diphtheriae is the classical etiological agent of diphtheria and the type strain of the genus Corynebacterium. While diphtheria of the respiratory tract became rare with the introduction of vaccination programs in industrialized countries, even today several thousand cases per year are reported to the World Health Organization. This shows that diphtheria is not completely eradicated and that reservoirs exist. The book summarizes the latest advances made in understanding C. diphtheriae and the closely related species Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Topics addressed are genomics of toxigenic corynebacteria, host-pathogen-interaction, detection, surveillance and treatment as well as application aspects.


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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Seitenzahl: 293
  • Erscheinungstermin: 29. Oktober 2013
  • Englisch
  • ISBN-13: 9789400776241
  • Artikelnr.: 43789961
Inhaltsangabe
1. Diphtheria and its etiological agents
Andreas Burkovski, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
2. Corynebacterium diphtheriae , Corynebacterium ulcerans and Corynebacterium pseudotuberculosis - General aspects
Ana Luíza de Mattos Guaraldi , Raphael Hirata Júnior & Vasco Ariston de Carvalho Azevedo
3. Comparative genomics and pathogenicity islands of Corynebacterium diphtheriae , Corynebacterium ulcerans , and Corynebacterium pseudotuberculosis
Eva Trost & Andreas Tauch
4. Corynephages: infections of the infectors
Vartul Sangal & Paul A Hoskisson
5. Toxin structure, delivery and action
Basak Varol, Bilge Özerman Edis & Muhammet Bekta
6. Iron Acquisition and Iron-Dependent Gene Expression in Corynebacterium diphtheriae
Michael P. Schmitt
7. Assembly and Function of Corynebacterium diphtheriae Pili
Melissa E. Reardon and Hung Ton-That
8. Toxigenic corynebacteria: Adhesion, invasion and host response
Lisa Ott & Andreas Burkovski
9. Detection methods for laboratory diagnosis of diphtheria
Anja Berger, Michael Hogardt, Regina Konrad & Andreas Sing
10. Diphtheria Surveillance
Karen S. Wagner, Katherina Zakikhany, Joanne M. White, Gayatri Amirthalingam, Natasha S. Crowcroft & Androulla Efstratiou
11. History of diphtheria vaccine development
Enrico Malito & Rino Rappuoli
12. Antimicrobial susceptibility and treatment
Aleksandra Anna Zasada
13. Sialidases of Corynebacteria and their Biotechnological Applications
14. Molecular Genetic Tools for Research in Corynebacterium diphtheriae
Diana M. Oram
15. Diphtheria toxin based molecules as therapeutic approaches
Ingo Schubert
Rezensionen
From the book reviews:

It extensively examines the genomics, pathogenicity, diagnosis, and treatment of these bacteria as well as vaccine development. an excellent resource for graduate, postdoctoral fellows, and basic scientists in microbiology, molecular genetics, or public health. It also would be a useful introductory tool for infectious disease fellows who are interested in pursuing public health and/or basic science research as part of a physician/scientist training pathway. (Shirley F. Delair, Doody s Book Reviews, August, 2014)