The purpose of Central Nervous System Inflammation and Disease is to provide a succinct and well-organized reference volume focused on inflammatory CNS disease to a wide audience. In particular, this text is comprised of four sections revolving around current areas of interest within the field of neuroimmunology, virology, pharmacology and disease. Sections of this text focus on a specific category of diseases as well as the pharmacological, virological, and immunological effects of and on the disease. For example, this text explores how chemokines affect disease. Although many have covered this topic, few have broken it down at this level. Each disease is broken down on a variety of scientific levels without getting into the history of the disease. At this level, we believe the targeted audience is familiar with the background information. This approach provides a succinct overview of a specific subject relating to interrelated topics pertaining to neurology, immunology and disease. TOC:Section I - Microglia and CNS Disease.- 1. Microglia: a CNS-Specific Tissue Macrophage.- Shweta S. Puntambekar, Jonathan M. Doose, Monica J Carson.- 2. Mechanisms of Microglial Activation by Amyloid Precursor Protein and its Proteolytic Fragments.- S. A. Austin and C. K. Combs.- 3. Pericytes.- Martin Krüger and Ingo Bechmann.- 4. Imaging Microglia in the Central Nervous System: Past, Present, and Future.- Dimitrios Davalos and Katerina Akassoglou.- Section II - Innate Immune Responses within the Brain.- 5. Cytokines in CNS inflammation and disease.- Malú G. Tansey and Tony Wyss-Coray.- 6. Arachidonic acid metabolites: Function in neurotoxicity and inflammation in the central nervous system.- and T.J. Montine.- 7. Pattern Recognition Receptors in CNS Disease.- Pamela A. Carpentier, D'Anne S. Duncan, Stephen D. Miller.- 8. The Complement System in the CNS: Thinking again.- Andrea J. Tenner and Karntipa Pisalyaput.- Section III - Chemokines and CNS Disease.- 9. Chemokines and autoimmune demyelination.- Michaela Fux, Jason Millward, and Trevor Owens.- 10. Chemokine actions in the CNS: Insights from transgenic models.- Marcus Müller and Iain L. Campbell.- 11. Chemokines and Spinal Cord Injury.- Maya N. Hatch and Hans S. Keirstead.- 12. The Usual Suspects: Chemokines and Microbial Infection of the Central Nervous System.- Michelle J. Hickey, Linda N. Stiles, Chris S. Schaumburg, and Thomas E. Lane.- Section IV - Antigen Presentation and Immune Responses within the Brain.- 13. CNS Dendritic Cells in Inflammation and Disease.- Samantha L. Bailey and Stephen D. Miller.- 14. MHC class I Expression and CD8+ T Cell Function: Towards the Cell Biology of T-APC Interactions in the Infected Brain.- Cornelia Bergmann and Pedro Lowenstein.
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