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The purpose of this book is to present clinically relevant basic mechanisms of excitotoxic neuronal death, which in the adult mammalian brain is morphologically necrotic, not apoptotic, and which involve caspase-independent mechanisms of programmed cell death. The spectrum of clinically relevant pathologically induced excitotoxic neuronal death includes cerebral ischemia, traumatic brain injury, cerebral hypoglycemia, and status epilepticus. By investigating mechanisms, potential neuroprotective strategies can be identified that may have future clinical application.…mehr

Produktbeschreibung
The purpose of this book is to present clinically relevant basic mechanisms of excitotoxic neuronal death, which in the adult mammalian brain is morphologically necrotic, not apoptotic, and which involve caspase-independent mechanisms of programmed cell death. The spectrum of clinically relevant pathologically induced excitotoxic neuronal death includes cerebral ischemia, traumatic brain injury, cerebral hypoglycemia, and status epilepticus. By investigating mechanisms, potential neuroprotective strategies can be identified that may have future clinical application.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 12.01.2010
  • Englisch
  • ISBN-13: 9780387732268
  • Artikelnr.: 37287219
Autorenporträt
Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism and the Society for Neuroscience.
Inhaltsangabe
INTRODUCTION: Programmed mechanisms and the clinical spectrum of excitotoxic neuronal death (Denson G. Fujikawa).- PART 1: Caspase-independent programmed cell death: general considerations.- Chapter 1: Caspase-independent cell death mechanisms in simple animal models (Matthias Rieckher and Nektarios Tavernarakis).- Chapter 2: Programmed necrosis: a 'new' cell death outcome for injured adult neurons? (Slavica Krantic and Santos A. Susin).- Chapter 3: Age-dependence of neuronal apoptosis and of caspase activation (Denson G. Fujikawa).- Chapter 4: Excitotoxic programmed cell death involves caspase-independent mechanisms (Ho Chul Kang, Ted M. Dawson and Valina L. Dawson).- PART 2: Focal Cerebral ischemia.- Chapter 5: Apoptosis-inducing factor translocation to nuclei in focal cerebral ischemia (Carsten Culmsee and Nicholas Plesnila).- Chapter 6: The role of poly(ADP-ribose) polymerase-1 (PARP-1) activation in focal cerebral ischemia (Giuseppe Faraco and Alberto Chiarugi).- PART 3: Transient Global Ischemia.- Chapter 7: Transient global cerebral ischemia produces necrotic, not apoptotic neurons (Frederick Colbourne and Roland Auer).- Chapter 8: Apoptosis-inducing factor translocation to nuclei after transient global ischemia (Can Liu, Armando P. Signore, Guodong Cao and Jun Chen).- Chapter 9: Role of µ-calpain I and lysosomal cathepsins in hippocampal neuronal necrosis after transient global ischemia in primates (Anton B. Tonchev and Tetsumori Yamashima).- PART 4: Traumatic central nervous system (CNS) injury.- Chapter 10: Mitochondrial damage in traumatic CNS injury (Laurie M. Davis and Patrick G. Sullivan).- Chapter 11: Programmed mechanisms in traumatic CNS injury (Bogdan A. Stoica and Alan I. Faden).- PART 5: Hypoglycemic neuronal death.- Chapter 12: Hypoglycemic neuronal death: morphological considerations (tentative title pending receipt of manuscript; Roland Auer).- Chapter 13:The role of poly(ADP-ribose) polymerase-1 (PARP-1) in hypoglycemic neuronal death (tentative title pending receipt of manuscript; Sang Won Suh and Raymond A. Swanson).- PART 6: Seizure-induced neuronal death.- Chapter 14: p53 activation is necessary in seizure-induced neuronal death (Zhiquin Tan and Steven S. Schreiber).- Chapter 15: DNA damage and repair in the brain: implications for seizure-induced neuronal injury, endangerment, and neuroprotection (Samantha L. Crowe and Alexei D. Kondratyev).- Chapter 16: Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis (Denson G. Fujikawa).- CONCLUDING REMARKS (Denson G. Fujikawa)
Rezensionen
"This is an outstanding book concerning the molecular and cellular mechanisms of trauma and ischemia in the mammalian brain. ... I recommend his book to neurophysiologists, neurologists, and neurosurgeons." (Joseph J. Grenier, Amazon.com, September, 2015)