Arthur Greenberg / Curt M. Breneman / Joel F. Liebman (Hgg.)

The Amide Linkage

Structural Significance in Chemistry, Biochemistry, and Materials Science
Herausgegeben:Greenberg, Arthur; Breneman, Curt M.; Liebman, Joel F.

• Gebundenes Buch

Produktbeschreibung

Die Peptidbindung ist eine der wichtigsten und häufigsten chemischen Bindungen in der Natur. Sie bestimmt die Eigenschaften von organischen Molekülen und Makromolekülen, Peptiden und Proteinen. Dieser Band bietet eine Fülle von Details zur Struktur, Bindung und Energetik, Elektronendichteverteilung, Amidrotation, Stereochemie, Spektroskopie und Thermochemie. Spezielle Aspekte wie die stereospezifische Synthese kommen ebenso zur Sprache wie Einzelheiten der Funktion der Peptidbindung in Enzyminhibitoren, cyclischen Peptiden und bakteriziden Wirkstoffen.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 672
• Erscheinungstermin: 4. Januar 2000
• Englisch
• Abmessung: 243mm x 165mm x 39mm
• Gewicht: 1064g
• ISBN-13: 9780471358930
• ISBN-10: 0471358932
• Artikelnr.: 09459294

Autorenporträt

ARTHUR GREENBERG, PhD, is Professor in the Department of Chemistry at the University of New Hampshire. CURT M. BRENEMAN, PhD, is Professor in the Department of Chemistry at Rensselaer Polytechnic Institute. JOEL F. LIEBMAN, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland, Baltimore County.

Inhaltsangabe

The Electron Density Distribution of Amides and Related Compounds (C.
Breneman & M. Martinov). Origin of the Amide Rotational Barrier (K.
Wiberg). The Amide Linkage as a Ligand-Its Properties and the Role of
Distortion (A. Greenberg). Studies in Amide Hydrolysis: The Acid, Base, and
Water Reactions (R. Brown). The Thermochemistry of Amides (J. Liebman, et
al.). Stereospecificity in the -Lactam (Aziridinone) Synthon (R. Hoffman).
-Lactams: Cyclic Amides of Distinction (A. Bose, et al.). Sterically
Hindered Twisted Amides (S. Yamada). Photoelectron Spectroscopy of Amides
and Lactams (P. Rademacher). The Role of Amides in the Noncovalent
Synthesis of Supramolecular Structures in Solution, at Interfaces, and in
Solids (G. Palmore & J. MacDonald). -Lactam Antibacterial Agents:
Computational Chemistry Investigations (D. Boyd). Three-Dimensional Design
of Enzyme Inhibitors with Heterocyclic Amide Bond Mimics (R. Bohacek & W.
Shakespeare). Ab Initio Conformational Analysis of Protein Subunits: A Case
Study of the Serine Diamide Model (A. Perczel & I. Csizmadia). Gas-Phase
Ion Chemistry of Amides, Peptides, and Proteins (C. Cassady). -Sheet
Interactions Between Proteins (S. Maitra & J. Nowick). Head-to-Tail Cyclic
Peptides and Cyclic Peptide Libraries (A. Spatola & P. Romanovskis). From
Crystal Structures of Oligopeptides to Protein Folding. The Importance of
Peptide Bond-Side Chain Hyperconjugation (A. Cieplak). Role of the Peptide
Bond in Protein Structure and Folding (N. Kallenbach, et al.). Index.

Rezensionen

"It makes extremely interesting reading" (Angewandte Chemie, International Edition 19 November 2001)

"...will have a longer than average shelf life..."(European Peptide Society Newsletter, 1 January 2003)

"...excellent chapters and provides plenty of useful background information on amide structure." (Angewandte Chemie, International Edition, Vol. 42, 2003)