Classics in Stereoselective Synthesis - Carreira, Erick M.; Woerpel, Keith A.; Reiser, Oliver
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Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an.

Produktbeschreibung
Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an.
  • Produktdetails
  • Verlag: Wiley-VCH / Wiley-VCH GmbH
  • Artikelnr. des Verlages: 1129966 000
  • Erscheinungstermin: 17. Dezember 2008
  • Englisch
  • Abmessung: 251mm x 193mm x 38mm
  • Gewicht: 1442g
  • ISBN-13: 9783527299669
  • ISBN-10: 3527299661
  • Artikelnr.: 20870214
Autorenporträt
Erick M. Carreira, born in La Habana, Cuba, obtained a B.S. degree in 1984 from the University of Illinois at Urbana Champaign under the supervision of Scott E. Denmark, and a PhD in 1990 from Harvard University under the supervision of David A. Evans. After carrying out postdoctoral work with Peter Dervan at the California Institute of Technology through mid-1992, he joined the faculty at the same institution as an assistant professor of chemistry and was promoted to full professor in 1997. In 1998, he moved to the Laboratory of Organic Chemistry at the ETH-Zurich, Switzerland. He has over 180 research publications and numerous patents to his name. He is the recipient of, among others, the American Chemical Society Award in Pure Chemistry the Nobel Laureate Signature Award, and he has held the David and Lucile Packard Foundation Fellowship in Science and Engineering as well as the Tetrahedron Chair Prize. Professor Carreira's research program is focused on the four interrelated areas of organic synthesis: catalysis, methodology, natural products synthesis, and bioorganic chemistry. Lisbet Kvaerno, born in Denmark, received her M.Sc. in chemistry from the University of Copenhagen under Prof. Jesper Wengel. She obtained her PhD in 2004 after working in total synthesis at the Technical University of Denmark under Prof. David Tanner and in medicinal chemistry at the ETH Zurich supervised by Prof. Erick M. Carreira. As a postdoctoral fellow in the research group of Prof. David A. Evans at Harvard University, she completed the total synthesis of the marine natural product (+)-azaspiracid. After a brief period as an independent junior group leader at the Max Planck Institute of Coal Research in Muelheim, Germany, she joined Lundbeck in Copenhagen as a process chemist in the late summer of 2008.
Inhaltsangabe
MACROCYCLIC STEREOCONTROL Introduction Background Conformational Control in Medium
Sized Rings Asymmetric Synthesis with Medium
Sized Rings Case Studies in Natural Products Total Synthesis Macrocyclic Stereocontrol in Cyclic Peptides Appendix: Macrocycle Formation CARBONYL ADITION REACTIONS Introduction Non
Chelated 1,2
Asymmetric Induction and the Operation of Steric and Electronic Effects 1,2
Asymmetric Induction Predicated on Chelation Control 1,3
Asymmetric Induction from CBeta Stereogenic Centers Asymmetric Induction by Remote Stereocenters (Beyond 1,3
Induction) Catalytic Enantioselective Carbonyl Additions of Arganozinc Species Enantioselective Ketone Reduction Enzymatic Reduction of Ketones Enantioselective Formation of Cyanohydrins Enantioselective Alkyne Additions Asymmetric Carbonyl
Ene Reactions ALPHA
FUNCTIONALIZATIONS OF ENOLATES Introduction Diastereoselective Alpha
Alkylations of Chiral Enolates Heteroatom
Substituted Enolates Asymmetric Enolate Alkylations Using Chiral Auxiliaries Enantioselective Enolate Alkylations Alpha
Hydroxylations of Enolates Alpha
Halogenations of Enolates ALDOL REACTIONS Introduction Chiral Enolates Through the Use of Chiral Auxiliaries or Chiral Controller Groups Substrate Control with Chiral Carbonyl Compounds Catalytic Enantioselective Aldol Reactions ALLYLATIONS OF C=O BONDS Introduction Reactivity of Allylmetal Reagents Boronate Additions Enantioselective Additions of Optically Active Allylic Boron Reagents Diastereoselecive Allylations with Chiral Boron Reagents Mechanistic Aspects
Lewis Acid
Promoted Addition of Allylsilanes and Allylstannanes to Aldehydes Chelation Control in the Allylation of Alpha
and Beta
Alkoxy Aldehydes Allylchromium Reagents Diastereoselective Allylations with Chiral Silanes and Stannanes Catalytic Asymmetric Allylations CHIRAL ACETALS Introduction Diastereoselective Reactions of Chiral Acetals Glycosylations Spiroketals in Natural Product Synthesis ALKENE HYDROBORATION Introduction Hydroborations with Acyclic Stereocontrol Metal
Catalyzed Hydroborations Asymmetric Hydroborations with Chiral Boranes Catalytic Asymmetric Hydroboration, Hydrosilylation, and Hydroalumination REDUCTIONS OF OLEFINS Introduction Diastereoselective Olefin Reductions by Catalytic Hydrogenation Alternative Methods for Diastereoselective Olefin Reductions Catalytic Asymmetric Olefin Hydrogenations OXIDATIONS OF OLEFINS Introduction Diastereoselective Epoxidations Enantioselective Epoxidations Asymmetric Ring
Opening of Epoxides Synthesis of Aziridines Iodolactonizations and Other Olefin Cyclizations Induced by Electrophiles Diastereoselective Dihydroxylations of Olefins Enantioselective Dihydroxylations of Olefins Enantioselective Aminohydroxylation of Olefins AMINO ACIDS Introduction Enantioselective Hydrogenations of Alpha, Beta
Didehydroamino Acids Enolate Alkylations in the Presence of Chiral Auxiliaries Alkylation of Glycine Anion Equivalents in the Presence of Chiral Phase
Transfer Catalysts Enolate Aminations Enzymatic Syntheses of Alpha
Amino Acids Catalytic Asymmetric Strecker Reactions ADDITIONS TO C=N BONDS Introduction Substrate
Controlled Diastereoselective Additions to C=N Bonds Additions to Imine Derivatives Bearing N
Bound Auxiliaries Formation of Beta
Lactams Through Staudinger Reactions Intramolecular Diastereoselective Iminium Ion Cyclizations Pictet
Spengler Reactions Catalytic Asymmetric Reductions of Imines and Imine Derivatives Catalytic Enantioselective Mannich and Mannich
Type Reactions Enantioselective Additions of Carbon Nucleophiles to C=N Bonds CONJUGATE ADDITIONS Introduction Diastereoselective Conjugate Additions Diastereoselective Conjugate Additions with Use of Chiral Auxiliaries Enantioselective Conjugate Additions of Enolates and other Stabilized Carbon Nucleophiles Enantioselective Conjugate Additions of Organometallic Species Enantioselective Conjugate Additions of Radicals Enantioselective Conjugate Additions of Heteroatom Nucleophiles Conjugate Reductions Catalytic Enantioselective Stetter Reactions CHIRAL CARBONIONS Introduction Organolithium Reagents by Transmetalation of Organostannanes Carbanions by Reductive Methods Chiral Carbanions by Deprotonation Sulfoxide
and Phosphorus
Stabilized Carbanions Metal
Mediated Enantioselective Olefin Functionalizations METAL
CATALYZED ALLYLATIONS Introduction Diastereoselective Palladium
Catalyzed Allylation Reactions Enantioselective Palladium
Catalyzed Allylation Reactions Iridium
Catalyzed Enantioselective Allylation Reactions Copper
Catalyzed SN2' Allylation Reactions Enantioselective Allylation Reactions Catalyzed by Other Transition Metals Asymmetric Ring
Opening Reactions of Unsaturated Heterocycles CYCLOPROPANATIONS AND C
H INSERTION REACTIONS Introduction Diastereoselective Cyclopropanations with Carbenoids Generated from Diazoalkanes Enantioselective Dyclopropanations with Carbenoids Generated from Diazoalkanes Diastereoselective Simmons
Smith Cyclopropanations Enantioselective Simmons
Smith Cyclopropanations Alternative Classes Cyclopropanations Diastereoselective C
H Bonds SIGMATROPIC REARRANGEMENTS Introduction Claisen and Claisen
Type [3,3]
Sigmatropic Rearrangements Cope and Cope
Type [3,3]
Sigmatropic Rearrangements [2,3]
Sigmatropic Rearrangements Ene Reactions Nazarov Cyclizations DIELS
ALDER AND HETERO
DIELS
ALDER REACTIONS Introduction Diastereoselective Intermolecular Diels
Alder Reactions Diastereoselective Intramolecular Diels
Alder Reactions Diastereoselective Diels
Alder Reactions Using Chiral Auxiliaries Catalytic Enantioselective Diels
Alder Reactions Diastereoselective Hetero
Diels
Alder Reactions Enantioselective Hetero
Diels
Alder Reactions [3+2]
AND [2+2]
CYCLOADDITION REACTIONS Introduction Substrate
Controlled Diastereoselective [1,3]
Dipolar Cycloadditions Diastereoselective [1,3]
Dipolar Cycloadditions Using Chiral Auxiliaries Catalytic Enantioselective [1,3]
Dipolar Cycloadditions [3+2]
Cycloadditions with Trimethylenemethane Equivalents Ketene Cycloadditions Photochemical [2+2]
Cycloadditions