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Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms underlying posttranscriptional gene regulation. It focuses on RNA processing mechanisms in eukaryotic cells. With chapters on RNA splicing, RNA interference, MicroRNA regulation, RNA editing and other biological processes involving RNAs, the book also discusses critical roles of RNA processing in the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, in clinics as well as in the pharmaceutical industry.…mehr
Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms underlying posttranscriptional gene regulation. It focuses on RNA processing mechanisms in eukaryotic cells. With chapters on RNA splicing, RNA interference, MicroRNA regulation, RNA editing and other biological processes involving RNAs, the book also discusses critical roles of RNA processing in the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, in clinics as well as in the pharmaceutical industry.
Jane Y. Wu is the Charles Louis Mix Professor in the Department of Neurology, the Lurie Cancer Center and the Center for Genetic Medicine at Northwestern University in Chicago, USA as well as a senior consulting investigator at the Chinese Academy of Science, Beijing, China. After obtaining her doctorate from Stanford University and her postdoctoral training at Harvard University, Dr. Wu has been focusing on studying molecular mechanisms controlling gene regulation, in particular, those critical for neural development and neurodegeneration. Her research has significantly advanced our understanding of the fundamental role of RNA processing in biology and in human pathogenesis.
Inhaltsangabe
The Role of Co-transcriptional Recruitment of RNA Binding Proteins in the Maintenance of Genomic Stability (Jennifer A. Aoki and James L. Manley) Transcription Termination by RNA Polymerase II (Minkyu Kim and Stephen Buratowski) Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing (Louis Valente Yukio Kawahara, Boris Zinshteyn, Hisashi Iizasa and Kazuko Nishikura) Posttranslational Modification of Sm Proteins: Diverse Roles in sn RNP Assembly and Germ Line Specification (Graydon B. Gonsalvez and A. Gregory Matera) Structure, Function, and Biogenesis of Small Nucleolar Ribonucleoparticles (Katherine S. Godin and Gabriele Varani) Mechanistic Insights into Mammalian pre-mRNA Splicing (Sebastian M. Fica, Eliza C. Small, Melissa Mefford, and Jonathan P. Staley) Splicing Decisions Shape Neuronal Protein Function Across the Transcriptome (Jill A. Dembowski and Paula J. Grabowski) Noncoding RNA: The Major Output of Gene Expression (Matthias Harbers and Piero Carninci) Noncoding RNAs, Neurodevelopment and Neurodegeneration (Mengmeng Chen, Jianwen Deng, Mengxue Yang, Kun Zhu, Jianghong Liu, Li Zhu, and Jane Y. Wu) The Evolution of the Modern RNA World (Ying Chen, Hongzheng Dai and Manyuan Long)
The Role of Co-transcriptional Recruitment of RNA Binding Proteins in the Maintenance of Genomic Stability (Jennifer A. Aoki and James L. Manley) Transcription Termination by RNA Polymerase II (Minkyu Kim and Stephen Buratowski) Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing (Louis Valente Yukio Kawahara, Boris Zinshteyn, Hisashi Iizasa and Kazuko Nishikura) Posttranslational Modification of Sm Proteins: Diverse Roles in sn RNP Assembly and Germ Line Specification (Graydon B. Gonsalvez and A. Gregory Matera) Structure, Function, and Biogenesis of Small Nucleolar Ribonucleoparticles (Katherine S. Godin and Gabriele Varani) Mechanistic Insights into Mammalian pre-mRNA Splicing (Sebastian M. Fica, Eliza C. Small, Melissa Mefford, and Jonathan P. Staley) Splicing Decisions Shape Neuronal Protein Function Across the Transcriptome (Jill A. Dembowski and Paula J. Grabowski) Noncoding RNA: The Major Output of Gene Expression (Matthias Harbers and Piero Carninci) Noncoding RNAs, Neurodevelopment and Neurodegeneration (Mengmeng Chen, Jianwen Deng, Mengxue Yang, Kun Zhu, Jianghong Liu, Li Zhu, and Jane Y. Wu) The Evolution of the Modern RNA World (Ying Chen, Hongzheng Dai and Manyuan Long)
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