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  • Gebundenes Buch

Molecular Epidemiology of Chronic Diseases is an easy-to-use, simple handbook that allows epidemiologists to understand the specifics of research involving biomarkers, and laboratory scientists to understand the main issues of epidemiological study design and analysis. Invaluable as a tool for courses on molecular epidemiology, the book incorporates chapters on novel technologies (genomics, transcriptomics, proteomics, metabonomics) that are finding applications in population studies, as well as new statistical and bioinformatics approaches necessitated by the large data sets generated using…mehr

Produktbeschreibung
Molecular Epidemiology of Chronic Diseases is an easy-to-use, simple handbook that allows epidemiologists to understand the specifics of research involving biomarkers, and laboratory scientists to understand the main issues of epidemiological study design and analysis. Invaluable as a tool for courses on molecular epidemiology, the book incorporates chapters on novel technologies (genomics, transcriptomics, proteomics, metabonomics) that are finding applications in population studies, as well as new statistical and bioinformatics approaches necessitated by the large data sets generated using these methodologies.
Die Epidemiologie ist zunehmend angewiesen auf laborgenerierte Biomarker-Daten, und das Verständnis von Krankheitsmechanismen ist von steigender Bedeutung für die Erläuterungen der Ätiologie. Deshalb bedarf es eines Buches, das die disziplinären Grenzen überbrückt und allen relevanten Forschungsgruppen (Laborwissenschaftlern, Epidemiologen, klinischen Forschern und Statistikern) zugänglich ist. Zurzeit gibt es kein Werk mit einem expliziten Praxisschwerpunkt, das diese Bandbreite bietet. Diese Lücke füllt das vorliegende Handbuch. Es gibt Epidemiologen Einblick in die Forschung, insbesondere zu Biomarkern, und ermöglicht es Laborwissenschaftlern, die Kernpunkte epidemiologischer Studien zu verstehen. Außerdem stellt es ein Tool für einen Kurs in molekularer Epidemiologie bereit. Einzelne Kapitel widmen sich neuen Technologien (Genomforschung, Proteomik, Metabonomik) sowie Herangehensweisen der Statistik und der Bioinformatik, die aufgrund der zu bewältigenden Datenmenge unerlässlich sind.
  • Produktdetails
  • Verlag: Wiley & Sons; Wiley
  • Seitenzahl: 384
  • Erscheinungstermin: Mai 2008
  • Englisch
  • Abmessung: 254mm x 192mm x 27mm
  • Gewicht: 1015g
  • ISBN-13: 9780470027431
  • ISBN-10: 0470027436
  • Artikelnr.: 23331942
Inhaltsangabe
Contributors. Acknowledgements. 1. Introduction: why molecular epidemiology? (Chris Wild
Seymour Garte and Paolo Vineis) 2. Study design (Paolo Vineis). 3. Molecular epidemiological studies that can be nested within cohorts (Andrew Rundle and Habibul Ahsan). 4. Family studies
haplotypes and gene association studies (Jennifer H. Barrett
D. Timothy Bishop and Mark M. Iles). 5. Individual susceptibility and gene-environment interaction (Seymour Garte). 6. Biomarker validation (Paolo Vineis and Seymour Garte). 7. Exposure assessment (Mark J. Nieuwenhuijsen). 8. Carcinogen metabolites as biomarkers (Stephen S. Hecht). 9. Biomarkers of exposure: adducts (David H. Phillips). 10. Biomarkers of mutation and DNA repair capacity (Marianne Berwick and Richard J. Albertini). 11. High-throughput techniques -genotyping and genomics (Alison M. Dunning and Craig Luccarini). 12. Proteomics and molecular epidemiology (Jeff N. Keen and John B.C. Findlay). 13. Exploring the contribution of metabolic profiling to epidemiological studies (M. Bictash
Elaine Holmes
H. Keun
P. Elliott and J. K. Nicholson). 14. Univariate and multivariate data analysis (Yu-Kang Tu and Mark S. Gilthorpe). 15. Meta-analysis and pooled analysis - genetic and environmental data (Camille Ragin and Emanuela Taioli). 16. Analysis of Complex datasets (Jason H. Moore
Margaret R. Karagas and Angeline S. Andrew). 17. Some implications of random exposure measurement errors in occupational and environmental epidemiology (S. M. Rappaport and L . L. Kupper). 18. Bioinformatics (Jason H. Moore). 19. Biomarkers
disease mechanisms and their role in regulatory decisions (Pier Alberto Bertazzi and Antonio Mutti). 20. Biomarkers as endpoints in intervention studies (Lynnette R. Ferguson). 21. Biological resource centres in molecular epidemiology: collecting
storing and analysing biospecimens (Elodie Caboux
Pierre Hainaut and Emmanuelle Gormally). 22. Molecular epidemiogy and ethics: biomarkers for disease susceptibility (Kirsi Vähäkangas). 23. Biomarkers for dietary carcinogens: the example of heterocyclic amines in epidemiological studies (Rashmi Sinha
Amanda Cross and Robert J. Turesky). 24. Practical examples: hormones (Sabina Rinaldi and Rudolf Kaaks). 25. Aflatoxin
hepatitis B virus and liver cancer: a paradigm for molecular epidemiology (John D. Gropman
Thomas. W. Kensler and Chris Wild). 26. Complex exposures - air pollution (Steffen Loft
Elvira Vaclavik Brauner
Lykke Forchhammer
Marie Pedersen
Lisbeth E. Knudsen and Peter Moller). Index.
Rezensionen
"I think this is an excellent book I recommend it to anyone involved in molecular epidemiology.... The 26 chapters are written by topic specialists, in an explanatory, easy to read style." ( BTS Newsletter , Summer 2009) "This text provides an accessible and useful handbook for the epidemiologist who wants to survey the field, to become better informed, to look at recent developments and get some background on these or simply to appreciate further the relatively rapid changes in informatic and analytical technologies which increasingly will serve and underpin future epidemiological studies. One of the strengths in this book is the extensive array of practical illustrative examples, and it would also in my opinion have useful potential as a teaching text." ( American Journal of Human Biology , March 2009)