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"I think this is an excellent book-I recommend itto anyone involved in molecular epidemiology... The 26 chapters arewritten by topic specialists, in an explanatory, east to readstyle." -BTS Newsletter, Summer 2009 "This text provides an accessible and useful handbook for theepidemiologist who wants to survey the field, to become betterinformed, to look at recent developments and get some background onthese or simply to appreciate further the relatively rapid changesin informatic and analytical technologies which increasingly willserve and underpin future epidemiological studies. One of…mehr
"I think this is an excellent book-I recommend itto anyone involved in molecular epidemiology... The 26 chapters arewritten by topic specialists, in an explanatory, east to readstyle." -BTS Newsletter, Summer 2009 "This text provides an accessible and useful handbook for theepidemiologist who wants to survey the field, to become betterinformed, to look at recent developments and get some background onthese or simply to appreciate further the relatively rapid changesin informatic and analytical technologies which increasingly willserve and underpin future epidemiological studies. One of thestrengths in this book is the extensive array of practicalillustrative examples, and it would also in my opinion have usefulpotential as a teaching text." -American Journal of HumanBiology, March 2009 With the sequencing of the human genome and the mapping of millionsof single nucleotide polymorphisms, epidemiology has moved into themolecular domain. Scientists can now use molecular markers to trackdisease-associated genes in populations, enabling them to studycomplex chronic diseases that might result from the weakinteractions of many genes with the environment. Use of theselaboratory generated biomarker data and an understanding of diseasemechanisms are increasingly important in elucidating diseaseaetiology. Molecular Epidemiology of Disease crosses thedisciplinary boundaries between laboratory scientists,epidemiologists, clinical researchers and biostatisticians and isaccessible to all these relevant research communities in focusingon practical issues of application, rather than reviews of currentareas of research. * Covers categories of biomarkers of exposure, susceptibility anddisease * Includes chapters on novel technologies: genomics,transcriptomics, proteomics and metabonomics, which areincreasingly finding application in population studies * Emphasizes new statistical and bioinformatics approachesnecessitated by the large data sets generated using these newmethodologies * Demonstrates the potential applications of laboratorytechniques in tackling epidemiological problems while consideringtheir limitations, including the sources of uncertainty andinaccuracy * Discusses issues such as reliability (compared to traditionalepidemiological methods) and the timing of exposure * Explores practical elements of conducting population studies,including biological repositories and ethics Molecular Epidemiology of Disease provides aneasy-to-use, clearly presented handbook that allows epidemiologiststo understand the specifics of research involving biomarkers, andlaboratory scientists to understand the main issues ofepidemiological study design and analysis. It also provides auseful tool for courses on molecular epidemiology, using manyexamples from population studies to illustrate key concepts andprinciples.
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Professor Chris Wild. Molecular Epidemiology Unit, Head, Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health, The LIGHT Laboratories, University of Leeds, UK. Professor Paolo Vineis. Chair in Environmental Epidemiology, Div of Primary Care and Population Health Sciences, Medicine, Imperial College, London, UK. Professor Seymour Garte. Professor of Environmental and Community Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey; Scientific Director, Genetics Research Institute, Milan, Italy. Center for Environmental Oncology, University of Pittsburgh Cancer Institute, Pittsburgh,?PA,?USA.
Contributors. Acknowledgements. 1. Introduction: why molecular epidemiology? (Chris Wild Seymour Garte and Paolo Vineis) 2. Study design (Paolo Vineis). 3. Molecular epidemiological studies that can be nested within cohorts (Andrew Rundle and Habibul Ahsan). 4. Family studies haplotypes and gene association studies (Jennifer H. Barrett D. Timothy Bishop and Mark M. Iles). 5. Individual susceptibility and gene-environment interaction (Seymour Garte). 6. Biomarker validation (Paolo Vineis and Seymour Garte). 7. Exposure assessment (Mark J. Nieuwenhuijsen). 8. Carcinogen metabolites as biomarkers (Stephen S. Hecht). 9. Biomarkers of exposure: adducts (David H. Phillips). 10. Biomarkers of mutation and DNA repair capacity (Marianne Berwick and Richard J. Albertini). 11. High-throughput techniques -genotyping and genomics (Alison M. Dunning and Craig Luccarini). 12. Proteomics and molecular epidemiology (Jeff N. Keen and John B.C. Findlay). 13. Exploring the contribution of metabolic profiling to epidemiological studies (M. Bictash Elaine Holmes H. Keun P. Elliott and J. K. Nicholson). 14. Univariate and multivariate data analysis (Yu-Kang Tu and Mark S. Gilthorpe). 15. Meta-analysis and pooled analysis - genetic and environmental data (Camille Ragin and Emanuela Taioli). 16. Analysis of Complex datasets (Jason H. Moore Margaret R. Karagas and Angeline S. Andrew). 17. Some implications of random exposure measurement errors in occupational and environmental epidemiology (S. M. Rappaport and L . L. Kupper). 18. Bioinformatics (Jason H. Moore). 19. Biomarkers disease mechanisms and their role in regulatory decisions (Pier Alberto Bertazzi and Antonio Mutti). 20. Biomarkers as endpoints in intervention studies (Lynnette R. Ferguson). 21. Biological resource centres in molecular epidemiology: collecting storing and analysing biospecimens (Elodie Caboux Pierre Hainaut and Emmanuelle Gormally). 22. Molecular epidemiogy and ethics: biomarkers for disease susceptibility (Kirsi Vähäkangas). 23. Biomarkers for dietary carcinogens: the example of heterocyclic amines in epidemiological studies (Rashmi Sinha Amanda Cross and Robert J. Turesky). 24. Practical examples: hormones (Sabina Rinaldi and Rudolf Kaaks). 25. Aflatoxin hepatitis B virus and liver cancer: a paradigm for molecular epidemiology (John D. Gropman Thomas. W. Kensler and Chris Wild). 26. Complex exposures - air pollution (Steffen Loft Elvira Vaclavik Brauner Lykke Forchhammer Marie Pedersen Lisbeth E. Knudsen and Peter Moller). Index.
"I think this is an excellent book I recommend it to anyone involved in molecular epidemiology.... The 26 chapters are written by topic specialists, in an explanatory, easy to read style." ( BTS Newsletter , Summer 2009) "This text provides an accessible and useful handbook for the epidemiologist who wants to survey the field, to become better informed, to look at recent developments and get some background on these or simply to appreciate further the relatively rapid changes in informatic and analytical technologies which increasingly will serve and underpin future epidemiological studies. One of the strengths in this book is the extensive array of practical illustrative examples, and it would also in my opinion have useful potential as a teaching text." ( American Journal of Human Biology , March 2009)
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