Gerhard Krauss

Biochemistry of Signal Transduction and Regulation (eBook, PDF)

• Format: PDF

Produktbeschreibung

Originally based on a graduate course taught by the author, this true classic has once again been extensively updated to incorporate key new findings in biological signaling. With over half of the content re-written, plus 70 brand new and 50 revised figures, this is the most up-to-date textbook on signaling available anywhere. Thanks to its clear structure, hundreds of illustrative drawings, as well as chapter introductions and newly added study questions, this text excels as a companion for a course on biological signaling, and equally as an introductory reference to the field for students and researchers. Generations of students and junior researchers have relied on "the Krauss" to find their way through the bewildering complexity of biological signaling pathways.

Produktdetails

• Verlag: Wiley-VCH
• Seitenzahl: 844
• Erscheinungstermin: 30. Januar 2014
• Englisch
• ISBN-13: 9783527667505
• Artikelnr.: 40474087

Autorenporträt

Gerhard Krauss is emeritus Professor of Biochemistry at the University of Bayreuth (Germany). His research is centered on the mechanism of interaction of DNA binding proteins and their target DNA. He is specifically interested in transcription factors, DNA methyl transferases and nucleotide excision repair. The idea for a textbook on Signal Transduction and Gene Regulation originates from a lecture course that he has been teaching at Bayreuth since the middle of the 1990s.

Inhaltsangabe

BASICS OF CELL SIGNALING Cell Signaling: Why, When and Where? Intercellular Signaling Hormones in Intercellular Signaling Intracellular Signaling: Basics Molecular Tools for Intracellular Signaling PROPERTIES OF SIGNALING PROTEINS AND ORGANIZATION OF SIGNALING Modular Structure of Signaling Proteins Modular Signaling Complexes Regulation of Signaling Enzymes by Effector Binding Posttranslational Modifications in Cellular Signaling Regulation by Phosphorylation Protein Lysine Acetylation Protein Methylation Ubiquitin Modification of Proteins Lipidation of Signaling Proteins Scaffold Proteins Organization of Signaling THE REGULATION OF GENE EXPRESSION The Basic Steps of Gene Expression The Components of the Eukaryotic Transcription Machinery The Principles of Transcription Regulation The Control of Transcription Factors Chromatin Structure and Transcription Regulation RNA PROCESSING, TRANSLATIONAL REGULATION AND RNA INTERFERENCE Pre-mRNA Processing Regulation at the Level of Translation Regulation by RNA Silencing SIGNALING BY NUCLEAR RECEPTORS Ligands of Nuclear Receptors Principles of Signaling by Nuclear Receptors Structure of Nuclear Receptors Transcriptional Regulation by Nuclear Receptors Regulation of Signaling by Nuclear Receptors Subcellular Localization of Nuclear Receptors Non-Genomic Functions of Nuclear Receptors and their Ligands G PROTEIN-COUPLED SIGNAL TRANSMISSION PATHWAYS Transmembrane Receptors: General Structure and Classification Structural Principles of Transmembrane Receptors G Protein-Coupled Receptors Regulatory GTPases The Heterotrimeric G-Proteins Receptor-Independent Functions of Heterotrimeric G-Proteins Effector Molecules of G-Proteins GPCR Signaling via Arrestin INTRACELLULAR MESSENGER SUBSTANCES: "SECOND MESSENGERS" General Properties of Intracellular Messenger Substances cAMP cGMP and Guanylyl Cyclases Metabolism of Inositol Phospholipids and Inositol Phosphates Storage and Release of Ca2+ Functions of Phosphoinositides Ca2+ as a Signal Molecule Diacylglycerol as a Signal Molecule Other Lipid Messengers The NO Signaling Molecule SER/THR-SPECIFIC PROTEIN KINASES AND PROTEIN PHOSPHATASES Classification, Structure and Characteristics of Protein Kinases Structure and Regulation of Protein Kinases Protein Kinase A The PI3 Kinase/Akt Pathway Protein Kinase C Ca2+/Calmodulin-Dependent Protein Kinases Ser/Thr-specific Protein Phosphatases SIGNAL TRANSMISSION VIA TRANSMEMBRANE RECEPTORS WITH TYRSINE-SPECIFIC PROTEIN KINASE ACTIVITY Structure and Function of RTKs Downstream Effector Proteins of RTKs Nonreceptor Tyrosine-Specific Protein Kinases, Non-RTKs Protein Tyrosine Phosphatases Adaptor Molecules of Receptor Tyrosine Kinases SIGNAL TRANSMISSIO VIA RAS PROTEINS The Ras Superfamily of Monomeric GTPases GTPase-Activating Proteins, GAPs, of the Monomeric GTPases Guanine Nucleotide Exchange Factors, GEFs, of the Monomeric GTPases Inhibitors of Guanine-Nucleotide Dissociation, GDIs The Ras Family of Monomeric GTPases Raf Kinase as an Effector of Signal Transduction by Ras Proteins Further Ras Family Members: R-Ras, Ral and Rap Reception and Transmission of Multiple Signals by Ras Protein The Further Branches of the Ras Superfamily INTRACELLULAR SIGNAL TRANSDUCTION: THE PROTEIN CASCADES OF THE MAP KINASE PATHWAYS Organization and Components of MAPK Pathways Regulation of MAPK Pathways by Protein Phosphatases and Inhibitory Proteins Specificity in MAPK Activation and Organization in Multiprotein Complexes The Major MAPK Pathways of Mammals MEMBRANE RECEPTORS WITH ASSOCIATED TYROSINE KINASE ACTIVITY Cytokines and Cytokine Receptors The Jak-Stat Pathway T and B Cell Receptors (TCRs and BCRs) Signal Transduction via Integrins OTHER TRANSMEMBRANE RECEPTOR CLASSES: SIGNALING BY TGFß-RECEPTORS, TNF-RECEPTORS, TOLL-RECEPTORS AND NOTH TGFß Receptor and Smad Protein Singaling Receptor Regulation by Intramembrane Proteolysis: The Notch Receptor Tumor Necrosis Factor Receptor (TNFR) Superfamily Toll-Like R

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BASICS OF CELL SIGNALING
Cell Signaling: Why, When and Where?
Intercellular Signaling
Hormones in Intercellular Signaling
Intracellular Signaling: Basics
Molecular Tools for Intracellular Signaling

PROPERTIES OF SIGNALING PROTEINS AND ORGANIZATION OF SIGNALING
Modular Structure of Signaling Proteins
Modular Signaling Complexes
Regulation of Signaling Enzymes by Effector Binding
Posttranslational Modifications in Cellular Signaling
Regulation by Phosphorylation
Protein Lysine Acetylation
Protein Methylation
Ubiquitin Modification of Proteins
Lipidation of Signaling Proteins
Scaffold Proteins
Organization of Signaling

THE REGULATION OF GENE EXPRESSION
The Basic Steps of Gene Expression
The Components of the Eukaryotic Transcription Machinery
The Principles of Transcription Regulation
The Control of Transcription Factors
Chromatin Structure and Transcription Regulation

RNA PROCESSING, TRANSLATIONAL REGULATION AND RNA INTERFERENCE
Pre-mRNA Processing
Regulation at the Level of Translation
Regulation by RNA Silencing

SIGNALING BY NUCLEAR RECEPTORS
Ligands of Nuclear Receptors
Principles of Signaling by Nuclear Receptors
Structure of Nuclear Receptors
Transcriptional Regulation by Nuclear Receptors
Regulation of Signaling by Nuclear Receptors
Subcellular Localization of Nuclear Receptors
Non-Genomic Functions of Nuclear Receptors and their Ligands

G PROTEIN-COUPLED SIGNAL TRANSMISSION PATHWAYS
Transmembrane Receptors: General Structure and Classification
Structural Principles of Transmembrane Receptors
G Protein-Coupled Receptors
Regulatory GTPases
The Heterotrimeric G-Proteins
Receptor-Independent Functions of Heterotrimeric G-Proteins
Effector Molecules of G-Proteins
GPCR Signaling via Arrestin

INTRACELLULAR MESSENGER SUBSTANCES: "SECOND MESSENGERS"
General Properties of Intracellular Messenger Substances
cAMP
cGMP and Guanylyl Cyclases
Metabolism of Inositol Phospholipids and Inositol Phosphates
Storage and Release of Ca2+
Functions of Phosphoinositides
Ca2+ as a Signal Molecule
Diacylglycerol as a Signal Molecule
Other Lipid Messengers
The NO Signaling Molecule

SER/THR-SPECIFIC PROTEIN KINASES AND PROTEIN PHOSPHATASES
Classification, Structure and Characteristics of Protein Kinases
Structure and Regulation of Protein Kinases
Protein Kinase A
The PI3 Kinase/Akt Pathway
Protein Kinase C
Ca2+/Calmodulin-Dependent Protein Kinases
Ser/Thr-specific Protein Phosphatases

SIGNAL TRANSMISSION VIA TRANSMEMBRANE RECEPTORS WITH TYRSINE-SPECIFIC PROTEIN KINASE ACTIVITY
Structure and Function of RTKs
Downstream Effector Proteins of RTKs
Nonreceptor Tyrosine-Specific Protein Kinases, Non-RTKs
Protein Tyrosine Phosphatases
Adaptor Molecules of Receptor Tyrosine Kinases

SIGNAL TRANSMISSIO VIA RAS PROTEINS
The Ras Superfamily of Monomeric GTPases
GTPase-Activating Proteins, GAPs, of the Monomeric GTPases
Guanine Nucleotide Exchange Factors, GEFs, of the Monomeric GTPases
Inhibitors of Guanine-Nucleotide Dissociation, GDIs
The Ras Family of Monomeric GTPases
Raf Kinase as an Effector of Signal Transduction by Ras Proteins
Further Ras Family Members: R-Ras, Ral and Rap
Reception and Transmission of Multiple Signals by Ras Protein
The Further Branches of the Ras Superfamily

INTRACELLULAR SIGNAL TRANSDUCTION: THE PROTEIN CASCADES OF THE MAP KINASE PATHWAYS
Organization and Components of MAPK Pathways
Regulation of MAPK Pathways by Protein Phosphatases and Inhibitory Proteins
Specificity in MAPK Activation and Organization in Multiprotein Complexes
The Major MAPK Pathways of Mammals

MEMBRANE RECEPTORS WITH ASSOCIATED TYROSINE KINASE ACTIVITY
Cytokines and Cytokine Receptors
The Jak-Stat Pathway
T and B Cell Receptors (TCRs and BCRs)
Signal Transduction via Integrins

OTHER TRANSMEMBRANE RECEPTOR CLASSES: SIGNALING BY TGFß-RECEPTORS, TNF-RECEPTORS, TOLL-RECEPTORS AND NOTH
TGFß Receptor and Smad Protein Singaling
Receptor Regulation by Intramembrane Proteolysis: The Notch Receptor
Tumor Necrosis Factor Receptor (TNFR) Superfamily
Toll-Like Receptor Signaling

CELL CYCLE CONTROL BY EXTERNAL SIGNALING PATHWAYS
Principles of Cell Cycle Control
Key Elements of the Cell Cycle Apparatus
Regulation of the Cell Cycle by Proteolysis
G1 Progression and S Phase Entry
Transit Through S-Phase and M-Phase
The DNA Damage and DNA Replication Checkpoints

MALFUNCTION OF SIGNALING PATHWAYS AND TUMORIGENESIS: ONCOGENES AND TUMOR SUPPRESSOR GENES
Basic Characteristics of Tumor Cells
Mutation in Cancer Cells
Common Physiologic Changes in Tumor Cells: The Hallmarks of Cancer
Signaling Proteins Mutated in Cancer: Oncogenes
Tumor Suppressor Genes: General Functions
The Tumor Suppressors Rb and ARF

APOPTOSIS
Overview of Apoptotic Pathways
Caspases: Death by Proteolysis
The Family of Bcl-2 Proteins: Gatekeepers of Apoptosis
The Mitochondrial Pathway of Apoptosis
Death Receptor-Triggered Apoptosis
Links of Apoptosis to Cellular Signaling Pathways