Thomas Andrew Waigh

Applied Biophysics (eBook, PDF)

A Molecular Approach for Physical Scientists

• Format: PDF

Produktbeschreibung

This book presents the fundamentals of molecular biophysics, and highlights the connection between molecules and biological phenomena, making it an important text across a variety of science disciplines. The topics covered in the book include: * Phase transitions that occur in biosystems (protein crystallisation, globule-coil transition etc) * Liquid crystallinity as an example of the delicate range of partially ordered phases found with biological molecules * How molecules move and propel themselves at the cellular level * The general features of self-assembly with examples from proteins * The phase behaviour of DNA The physical toolbox presented within this text will form a basis for students to enter into a wide range of pure and applied bioengineering fields in medical, food and pharmaceutical areas.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 436
• Erscheinungstermin: 27. September 2007
• Englisch
• ISBN-13: 9780470513163
• Artikelnr.: 37294455

Autorenporträt

Tom A.Waigh, Biological Physics, School of Physics and Astronomy, University of Manchester, UK

Inhaltsangabe

Preface. Acknowledgements. 1 The Building Blocks. 1.1 Proteins. 1.2 Lipids.
1.3 Nucleic Acids. 1.4 Carbohydrates. 1.5 Water. 1.6 Proteoglycans and
Glycoproteins. 1.7 Cells (Complex Constructs of Biomolecules). 1.8 Viruses
(Complex Constructs of Biomolecules). 1.9 Bacteria (Complex Constructs of
Biomolecules). 1.10 Other Molecules. Further Reading. Tutorial Questions. 2
Mesoscopic Forces. 2.1 Cohesive Forces. 2.2 Hydrogen Bonding. 2.3
Electrostatics. 2.4 Steric and Fluctuation Forces. 2.5 Depletion Forces.
2.6 Hydrodynamic Interactions. 2.7 Direct Experimental Measurements of
Intermolecular and Surface Forces. Further Reading. Tutorial Questions. 3
Phase Transitions. 3.1 The Basics. 3.2 Helix-Coil Transition. 3.3
Globule-Coil Transition. 3.4 Crystallisation. 3.5 Liquid-Liquid Demixing
(Phase Separation). Further Reading. Tutorial Questions. 4 Liquid
Crystallinity. 4.1 The Basics. 4.2 Liquid-Nematic-Smectic Transitions. 4.3
Defects. 4.4 More Exotic Possibilities for Liquid Crystalline Phases.
Further Reading. Tutorial Questions. 5 Motility. 5.1 Diffusion. 5.2 Low
Reynold's Number Dynamics. 5.3 Motility. 5.4 First Passage Problem. 5.5
Rate Theories of Chemical Reactions. Further Reading. Tutorial Questions. 6
Aggregating Self-Assembly. 6.1 Surfactants. 6.2 Viruses. 6.3 Self-Assembly
of Proteins. 6.4 Polymerisation of Cytoskeletal Filaments (Motility).
Further Reading. Tutorial Questions. 7 Surface Phenomena. 7.1 Surface
Tension. 7.2 Adhesion. 7.3 Wetting. 7.4 Capillarity. 7.5 Experimental
Techniques. 7.6 Friction. 7.7 Other Surface Phenomena. Further Reading.
Tutorial Question. 8 Biomacromolecules. 8.1 Flexibility of Macromolecules.
8.2 Good/Bad Solvents and the Size of Polymers. 8.3 Elasticity. 8.4 Damped
Motion of Soft Molecules. 8.5 Dynamics of Polymer Chains. 8.6 Topology of
Polymer Chains - Super Coiling. Further Reading. Tutorial Questions. 9
Charged Ions and Polymers. 9.1 Electrostatics. 9.2 Debye-Huckel Theory. 9.3
Ionic Radius. 9.4 The Behaviour of Polyelectrolytes. 9.5 Donnan Equilibria.
9.6 Titration Curves. 9.7 Poisson-Boltzmann Theory for Cylindrical Charge
Distributions. 9.8 Charge Condensation. 9.9 Other Polyelectrolyte
Phenomena. Further Reading. Tutorial Questions. 10 Membranes. 10.1
Undulations. 10.2 Bending Resistance. 10.3 Elasticity. 10.4 Intermembrane
Forces. Further Reading. Tutorial Questions. 11 Continuum Mechanics. 11.1
Structural Mechanics. 11.2 Composites. 11.3 Foams. 11.4 Fracture. 11.5
Morphology. Further Reading. Tutorial Questions. 12 Biorheology. 12.1
Storage and Loss Moduli. 12.2 Rheological Functions. 12.3 Examples from
Biology. Further Reading. Tutorial Questions. 13 Experimental Techniques.
13.1 Static Scattering Techniques. 13.2 Dynamic Scattering Techniques. 13.3
Osmotic Pressure. 13.4 Force Measurement. 13.5 Electrophoresis. 13.6
Sedimentation. 13.7 Rheology. 13.8 Tribology. 13.9 Solid Properties.
Further Reading. Tutorial Questions. 14 Motors. 14.1 Self-assembling
Motility - Polymerisation of Actin and Tubulin. 14.2 Parallelised Linear
Stepper Motors - Striated Muscle. 14.3 Rotatory Motors. 14.4 Ratchet
Models. 14.5 Other Systems. Further Reading. Tutorial Question. 15
Structural Biomaterials. 15.1 Cartilage - Tough Shock Absorber in Human
Joints. 15.2 Spider Silk. 15.3 Elastin and Resilin. 15.4 Bone. 15.5
Adhesive Proteins. 15.6 Nacre and Mineral Composites. Further Reading.
Tutorial Questions. 16 Phase Behaviour of DNA. 16.1 Chromatin - Naturally
Packaged DNA Chains. 16.2 DNA Compaction - An Example of Polyelectrolyte
Complexation. 16.3 Facilitated Diffusion. Further Reading. Appendix.
Answers to Tutorial Questions. Index.

Rezensionen

"Given the significant breadth and depth of this rapidly growing subject, Tom Waigh does a good job in providing a valuable bridge between physics and biology." ( The Higher Education Academy Physical Sciences Centre , June 2008)