Hans-Joachim Gabius (ed.)

The Sugar Code

Fundamentals of Glycosciences
Ed.: Gabius, Hans-Joachim

• Gebundenes Buch

Produktbeschreibung

Ein neues Lehrbuch der Glykobiologie, das einen umfassenden Einblick in die Biochemie und die biologische und medizinische Relevanz von glykosylierten Biomolekülen gibt. Zusammengestellt von einem führenden Pionier auf dem Gebiet gemeinsam mit einem internationalen Expertenteam.

Produktdetails

• Verlag: Wiley-VCH
• 1. Auflage
• Seitenzahl: 569
• Erscheinungstermin: September 2009
• Englisch
• Abmessung: 248mm x 181mm x 34mm
• Gewicht: 1260g
• ISBN-13: 9783527320899
• ISBN-10: 352732089X
• Artikelnr.: 23600621

Autorenporträt

Hans-Joachim Gabius obtained his Ph.D. in 1982 at the Max-Planck-Institute for Experimental Medicine in Göttingen. After doing post-doctoral research from 1984-1985 in the group of S. H. Barondes at the UC San Diego, he was appointed first as assistant professor for biochemistry at the Max-Planck-Institute for Experimental Medicine in Göttingen (1987) and then as associate professor for pharmaceutical chemistry at the University of Marburg (1991). Since 1993 he is heading the Institute for Physiological Chemistry, Faculty of Veterinary Medicine at the University of Munich. Prof. Gabius received numerous research awards including the Otto-Hahn-Medal (1983), the Award of the Dr. Carl-Duisberg-Foundation (1988) and the Award of the Paul-Martini-Foundation (1990). His research interests are focused on chemical, biophysical and biochemical analysis of protein - carbohydrate interactions with biomedical relevance, such as the development of glycoscientific strategies for tumor diagnosis and therapy and the elucidation of functions of mammalian lectins. His research led to a prominent placement in the ISI ranking of highly cited papers in 1998.

Inhaltsangabe

- Basics of the sugar code (alphabet, coding capacity etc.)

- 3D Aspects (conformers, flexibility; from disaccharides to substituted N- and O-glycans)

- Chemist's way to prepare oligosaccharides (with comparison to enzymatic mechanisms)

- Natural Glycosylation

- Analytical aspects (how to analyze glycans; MS, 2D chromatography, glycoproteomics)

- Glycoproteins

- N-Glycosylation (route, localization, function in ER/Golgi in quality control)

- O-Glycosylation (structural aspects, mucins; brief review on diversity of O-glycosylation; O-GlcNAcylation incl. O-mannosylation and O-fucosylation)

- Glycosylation in model organisms with relevance for allergy/recombinant production (insect, fish, nematode, plant; Campylobacter)

- GPI anchors (with medical relevance and potential for drug design)

- Glycolipids

- Proteoglycans and hyaluronic acid

- Polysaccharides and small molecules in plants

- Protein-carbohydrate interactions

- Basics (thermodynamics, chemical mapping, arrays, methods, structures)

- Lectins (primer, history)

- Animal lectins

- Bacterial/viral lectins (incl. anti-adhesion compounds and "Tamiflu")

- Microbial CBMs in polysaccharide degradation

- Plant lectins

- Carbohydrate-carbohydrate interactions

Biomedical Aspects

- Animal models and diseases with glycosylation deficiency

- Case Studies on:

- Embryogenesis/fertilization

- Glycans as markers in malignancy?

- Hematology (platelet)

- Inflammation/metastasis (e.g. role of sialylation/sulfation, apoptosis)

- Neurobiology

- Sugars as pharmaceuticals, 20070405