Francois Terrier

eBook, PDF

Modern Nucleophilic Aromatic Substitution (eBook, PDF)

Beschreibung

Providing an updated overview of SNAr substitutions, balancing both mechanistic and synthetic viewpoints, this book gives a comprehensive account of this versatile field. The first chapter deals with a mechanistic analysis of the factors governing the feasibility of SNAr substitutions, providing useful information to predict the regio- and stereoselectivity control of the reactions and to define the conditions for concerted SNAr processes. Reflecting the key role played by these species as intermediates in most SNAr reactions, Chapter 2 then discusses the chemistry of anionic s-complexes. Chapter 3 describes the new concept of superelectrophilicity which has emerged from the kinetic and thermodynamic data collected in the preceding chapters , while the numerous synthetic applications are considered in depth in the chapters that follow on intermolecular, intramolecular, and nucleophilic aromatic substitutions of hydrogen. The final chapter brings together concise yet comprehensive discussions surrounding SNAr photosubstitutions, radical substitutions, and ANRORC substitutions. Authored by an eminently respected chemist who has contributed greatly to the field over the past two decades, this is a valuable information source for all organic chemists working in academia or the pharmaceutical and agrochemical industries.

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Autor

Francois Terrier obtained his PhD from the University Pierre et Marie Curie in Paris, France, in 1968. After postdoctoral research with Prof. Bernasconi at the University of California, Santa Cruz, he was appointed Professor at the University of Rouen. In 1991, he moved to the University of Versailles, where he held a Professorship of Organic Chemistry until 2007. His research is focused on various topics dealing with reactivity and physical organic chemistry, namely nucleophilic aromatic substitutions and sigma-complexation processes, alpha-effect nucleophiles and proton transfers at carbon. He has published over 200 papers, as well as a number of book chapters and review articles.

Produktdetails

• Verlag: Wiley-VCH
• Erscheinungstermin: 11. Juni 2013
• Englisch
• ISBN-13: 9783527656172
• Artikelnr.: 38602222