
ROLE OF EMMPRIN, CyPA, MMP-1 AND MMP-2 IN PERIODONTITIS
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Matrix Metalloproteinases (MMPs) are the most important enzymes for Extracellular matrix maintenance. MMPs are also involved in several biological and pathological diseases. They are a great challenge for science due to its high complexity in regulation and activity. MMPs are regulated by EMMPRIN through paracrine manner or through cell-to-cell interaction. Cyclophilin A (CyPA) expression is correlated with MMP-1, MMP-2 and MMP-9 expression in inflamed gingiva. CyPA plays an important role in biological conditions like T-cell activation, protein folding and trafficking. Understanding its role ...
Matrix Metalloproteinases (MMPs) are the most important enzymes for Extracellular matrix maintenance. MMPs are also involved in several biological and pathological diseases. They are a great challenge for science due to its high complexity in regulation and activity. MMPs are regulated by EMMPRIN through paracrine manner or through cell-to-cell interaction. Cyclophilin A (CyPA) expression is correlated with MMP-1, MMP-2 and MMP-9 expression in inflamed gingiva. CyPA plays an important role in biological conditions like T-cell activation, protein folding and trafficking. Understanding its role in the development of diseases and its mode of action requires more studies.