Eliya Nenkova
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The role of BACE1 in Alzheimer's disease and its suitability as a therapeutic target (eBook, PDF)

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Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment, loss of neuronal cells and synaptic connections. The main pathological feature of the disease is the ß amyloid peptide, generated by the cleavage of the Amyloid Precursor Protein by the ß-secretase enzyme (Beta-site APP-cleaving enzyme 1 (BACE1)). There have been many factors involved in the increase in BACE1 gene expression and activity, including energy inhibition, hypoxia and increased cholesterol. The biological function of BACE1 makes it a perfect target for therapeutic treatment o...

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