The Medicinal Chemistry of Glucocorticoid Receptor Modulators (eBook, PDF)
Adrian Hobson
eBook, PDF

The Medicinal Chemistry of Glucocorticoid Receptor Modulators (eBook, PDF)

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This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the app...

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