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Systems biology of stress in Bacillus megaterium and its potential applications (eBook, PDF)

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Generally, once a producer has been genetically designed, optimal process parameters are established to maximise its potential for industrial production. Despite this upstream work, bacterial cells are constantly exposed to various kinds of stress during the whole production process, including e.g. mechanical induced stress, high nutrient or product concentrations and variations of temperature, medium composition or oxygen availability. In this context, the main objective of this work was to investigate more deeply the impact of harsh cultivation temperatures (between 15 and 45°C) and os...

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